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Upcoming Phase 2 Data Expected For Longeverons (NASDAQ: LGVN) Drug For the $4+ Billion Alzheimers Sector What To Look For

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1 year ago

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–News Direct–

By David Willey, Benzinga

Longeveron (NASDAQ: LGVN), a clinical-stage biopharma developing potential treatments for age-related and life-threatening diseases, is expecting data from its phase 2a trial for its Lomecel-B cellular drug in the next 3 to 4 months.

Longeverons primary drug candidate, a cell-based medicine, is being tested for several indications, including Aging-related Frailty, a rare pediatric disease called hypoplastic left heart syndrome (HLHS), and Alzheimers disease (AD). It is running phase 2 trials for each of these conditions and expects to announce top-line results for the AD trial soon.

A previous clinical study indicated that Lomecel-Bs mechanisms of action (MoA) had the potential to affect multiple AD markers simultaneously, such as reducing neuroinflammation, improving neural blood vessels, and decreasing the brain damage that comes from AD. According to Longeveron, other potential therapies being tested mainly target amyloid plaques or neurofibrillary tangles. Longeveron uses medicinal signaling cells (MSCs) that may cross the blood-brain barrier (based on results from animal studies) and are primarily aimed at downregulating inflammation, which is a pathway associated with ADs neurodegeneration, including memory loss.

Longeveron completed a randomized, placebo-controlled phase 1 trial that tested for safety as a primary objective, as well as potential efficacy. The trial saw no serious adverse events and indicated a statistically significant improvement in cognition in the patients. Importantly, the trial showed that Lomecel-B did not appear to cause ARIA (Alzheimers Related Imaging Abnormality), a serious potential side effect of some AD treatments.

These results led to Longeveron initiating a phase 2 trial late in 2022, a 41-week trial on 48 patients with mild AD. The primary objective for the trial is safety, though the Company is exploring signals for multiple secondary endpoints, including cognitive measures, the AD assessment scale for cognitive function (ADAS-Cog), and inflammatory biomarkers. In addition, the trial is also designed to test whether repeat dosing of Lomecel-B may produce greater drug efficacy. The Company anticipates that if the trial is successful and shows efficacy, there is the potential for Lomecel-B to be developed as a disease-modifying treatment for AD.

Longeverons Position In An Active Market

By developing Lomecel-B as a potential treatment for AD, Longeveron is positioning itself for potential success in a growing sector. With over 6 million Americans suffering from AD in 2021, there is a drive in the pharmaceutical sector to develop a range of treatments for the disease. Multiple companies are currently attempting to develop treatments, while others have received accelerated approval for their drugs from the FDA. The global market for Alzheimers Disease therapies was worth $4.05 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of about 20% from 2023 to 2030.

In 2021, Biogen Inc. (NASDAQ: BIIB) received accelerated approval from the FDA for its drug Aducanumab.

Acumen Pharmaceuticals (NASDAQ: ABOS) has completed a phase 1 trial for the drug ACU193, and Tiziana Life Sciences (NASDAQ: TLSA) has filed an investigational new drug (IND) application for its drug, Foralumab, for its AD indications.

Follow developments from Longeverons cell-based therapies on its website.

We are a clinical-stage biotechnology company developing cellular therapies for aging-related and life-threatening conditions.Our lead investigational product is Lomecel-B, which is derived from culture-expanded medicinal signaling cells (MSCs) that are sourced from bone marrow of young healthy adult donors. We believe that by using the same cells that promote tissue repair, organ maintenance, and immune system function, we can develop safe and effective therapies for some of the most difficult diseases and conditions associated with aging.

Forward-Looking StatementsCertain statements in this press release that are not historical facts are forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, which reflect management's current expectations, assumptions, and estimates of future operations, performance and economic conditions, and involve risks and uncertainties that could cause actual results to differ materially from those anticipated by the statements made herein. Forward-looking statements are generally identifiable by the use of forward-looking terminology such as "believe," "expects," "may," "looks to," "will," "should," "plan," "intend," "on condition," "target," "see," "potential," "estimates," "preliminary," or "anticipates" or the negative thereof or comparable terminology, or by discussion of strategy or goals or other future events, circumstances, or effects. Factors that could cause actual results to differ materially from those expressed or implied in any forward-looking statements in this release include, but are not limited to, statements regarding the offer and sale of securities, the terms of the offering, about the ability of Longeverons clinical trials to demonstrate safety and efficacy of the Companys product candidates, and other positive results; the timing and focus of the Companys ongoing and future preclinical studies and clinical trials and the reporting of data from those studies and trials; the size of the market opportunity for the Companys product candidates, including its estimates of the number of patients who suffer from the diseases being targeted; the success of competing therapies that are or may become available; the beneficial characteristics, safety, efficacy and therapeutic effects of the Companys product candidates; the Companys ability to obtain and maintain regulatory approval of its product candidates in the U.S., Japan and other jurisdictions; the Companys plans relating to the further development of its product candidates, including additional disease states or indications it may pursue; the Companys plans and ability to obtain or protect intellectual property rights, including extensions of existing patent terms where available and its ability to avoid infringing the intellectual property rights of others; the need to hire additional personnel and the Companys ability to attract and retain such personnel; the Companys estimates regarding expenses, future revenue, capital requirements and needs for additional financing; the Companys need to raise additional capital, and the difficulties it may face in obtaining access to capital, and the dilutive impact it may have on its investors; the Companys financial performance, and the period over which it estimates its existing cash and cash equivalents will be sufficient to fund its future operating expenses and capital expenditure requirements. Additionally, Longeveron makes no assurance that any public offering of its securities as described herein will occur at all, or that any such transaction will occur on the timelines, in the manner or on the terms anticipated due to numerous factors. Further information relating to factors that may impact the Company's results and forward-looking statements are disclosed in the Company's filings with the Securities and Exchange Commission, including Longeverons Annual Report on Form 10-K for the year ended December 31, 2022, filed with the SEC on March 14, 2023. The forward-looking statements contained in this press release are made as of the date of this press release, and the Company disclaims any intention or obligation, other than imposed by law, to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice.

Contact Details

Christine Petraglia – TraDigital IR

+1 844-470-2550

christine@tradigitalir.com

Company Website

https://longeveron.com/

View source version on newsdirect.com: https://newsdirect.com/news/upcoming-phase-2-data-expected-for-longeverons-nasdaq-lgvn-drug-for-the-4-billion-alzheimers-sector-what-to-look-for-124186029

LONGEVERON INC.

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Nextshoess: Dominating the Sneaker Game with Over 50,000 Instagram Followers and Premium Selections

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6 hours ago

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October 6, 2024

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Auckland, NZ, 6th October 2024, ZEX PR WIRE, Nextshoess, one of the fastest-growing online sneaker platforms, has quickly risen to prominence in the global sneaker community. With over 50,000 Instagram followers and a thriving customer base of more than 20,000 clients worldwide, Nextshoess is making waves as the go-to destination for sneaker enthusiasts seeking bold, fashionable designs at accessible prices.

Launched in April 2017, Nextshoess began with a simple dream: to create a platform that not only sold trendy sneakers but also fostered a community of like-minded individuals who share a passion for footwear. The founders recognized several challenges in the online sneaker market, particularly when it came to quality, customer service, and product authenticity. With this in mind, they made it their mission to revolutionize the industry, promising to put the needs of customers first, even at a higher cost.

A Mission to Redefine Sneaker Shopping

At its core, Nextshoess is driven by a simple philosophy: every step you take should come with personality. The brand curates a wide selection of high-quality sneakers from premium brands like Nike, Air Jordan, and Yeezy, ensuring that customers not only look stylish but also receive products that stand the test of time. From classic designs to limited-edition releases, Nextshoess has something for everyone, regardless of their fashion preferences.

However, what truly sets Nextshoess apart from its competitors is its commitment to building a community. By fostering a loyal following on social media, particularly Instagram, the brand has created a space where sneaker lovers from around the world can come together to share their love for shoes, discuss the latest trends, and engage with the brand on a personal level.

Customer-Centric Approach

In an industry where fast fashion often leads to compromises on quality, Nextshoess prides itself on offering premium products while maintaining a high standard of customer service. The company works closely with trusted retailers and boutiques globally to ensure that every order is fulfilled with care and precision. This means that customers can expect their sneakers to arrive on time and in pristine condition, every time.

“We understand that delivering high-quality service comes at a higher cost on our side, but it’s a responsibility we’re more than willing to take for our community,” said a spokesperson for Nextshoess. “Our customers are our top priority, and we want them to have a seamless, enjoyable shopping experience from start to finish.”

A Growing Global Presence

With its headquarters in Auckland, New Zealand, Nextshoess has built a global footprint, delivering sneakers to customers across the world. The brand’s focus on premium shipping and packaging ensures that products arrive safely, regardless of distance. The company’s carefully curated sneaker collection caters to both men and women, offering timeless designs that appeal to fashion-forward individuals of all ages.

What’s Next for Nextshoess?

As the sneaker industry continues to evolve, Nextshoess remains committed to staying ahead of the curve. The company is constantly expanding its product offerings, working with new partners, and exploring innovative ways to enhance the customer experience.

For more information, visit Nextshoess.co.nz and browse the latest collection of premium sneakers.

Press Contact: Nextshoess 

www. nextshoess.co.nz

Mount Wellington, Auckland 1060, New Zealand

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Dubai’s Ultimate Blockchain Event to Unite Visionary Innovators and Global Leaders

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6 hours ago

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October 6, 2024

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Dubai, United Arab Emirates, 6th October 2024, ZEX PR WIRE, Future Blockchain Summit 2024, the region’s most immersive large-scale blockchain event, is set to take place at the iconic Dubai Harbour from October 13-16, 2024. As the premier event in MENA, it will bring together more than 1200 investors, 120 exhibitors, and 150+ speakers from over 50 countries, uniting the blockchain and crypto ecosystem under one roof. This year’s event will be a hub for groundbreaking ideas and collaborations designed to shape the future blockchain technology and its impact on global industries.

Dubai, recognized as a global Web3 hub, offers a fertile ground for blockchain innovation, thanks to its forward-thinking government policies, comprehensive regulatory framework, and access to capital. Since its inception in 2018, aligned with the Dubai Blockchain Strategy and Emirates Blockchain Strategy, the Future Blockchain Summit has become the region’s flagship event for blockchain, spanning the vibrant tech markets of the Middle East, Africa, and Asia.

Peter Brady, Associate Vice President Technology Cluster at Dubai World Trade Centre, remarked, “Future Blockchain Summit 2024 will once again serve as a dynamic platform designed to empower disruptors and ignite sector growth. We are excited to bring together the brightest minds and leaders to foster collaboration, inspire transformation, and solidify Dubai’s position as a global hub for blockchain innovation.”

The 2024 edition will offer groundbreaking discussions on the convergence of blockchain with AI, the Internet of Things (IoT), and extended reality (XR). Leaders and innovators from Europe and North Africa will dive into how these combined technologies are transforming industries. Attendees will also gain invaluable insights on:

  • The rise of non-fungible tokens (NFTs) in protecting digital assets and reshaping ownership models.

  • Tokenization of traditional assets and the explosion of decentralized finance (DeFi), a force set to disrupt financial markets and create new investment avenues.

  • Digital identities in the Web3 era, a critical topic addressed by Brian Rose, Founder & Host of London Real, and Raido Saar, President of the Estonian Web3 Chamber. This session will explore how blockchain enables self-sovereign identities, empowering users to control their personal data and digital presence.

Key discussions will include Sebastien Borget, Co-Founder & COO of The Sandbox, and Yat Siu, Co-Founder & Executive Chairman of Animoca Brands, during the “Into the Metaverse” panel. They will delve into the impact of blockchain on gaming, community-driven ecosystems, and the role of AI, VR, and AR in creating next-gen gaming experiences. The future of decentralized game development and the rise of esports will also be explored, providing attendees with a comprehensive look at the future of the gaming industry.

Another must-attend session is the “Navigating Global Regulations” panel, which will compare regulatory frameworks across the US, Europe, and Asia, while emphasizing the role of compliance tools and regulatory sandboxes in enabling experimentation and cross-border collaboration.

Sponsors for this year’s summit include Bitpanda, Coin W, DMCC, Fastex, Toobit, Sui, Coindesk Indices, M2, Fasset, and others, all of whom are at the forefront of blockchain innovation.

For more information about the summit and agenda, visit www.futureblockchainsummit.com/

About Future Blockchain Summit

Future Blockchain Summit is the leading blockchain exhibition and MENA region’s most immersive large-scale blockchain event. Capitalising on Dubai’s status as a global Web3 hub, the event will unite the entire blockchain and crypto ecosystem and provide a leading platform to foster collaboration.

Powered by GITEX Global, the seventh edition of Future Blockchain Summit will bring together more than 1200 investors, 150 exhibitors, and 120 speakers from across countries at the iconic Dubai Harbour, from 13-16 October 2024. It will take place alongside GITEX Impact, Expand North Star, FinTech Surge and Marketing Mania.

Expand North Star

Expand North Star 2024, the world’s largest event for start-ups and investors, will bring together leading founders, VCs, tech innovators, and ecosystem enablers to the Dubai Harbour, taking place from 13-16 October 2024. Hosted by the Dubai Chamber of Digital Economy and organised by Dubai World Trade Centre, Expand North Star features four co-located events: GITEX IMPACT, Fintech Surge, Future Blockchain Summit, and Marketing Mania. This 9th edition will welcome over 1,800 global startup exhibitors, 1,200 investors, and 250 speakers from 100 countries. The show is inspired by the world largest tech show, GITEX GLOBAL, which will take place from 14-18 October 2024, at Dubai World Trade Centre. 

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Fintech Surge 2024: Revolutionising Finance With Cutting-Edge Innovations And Strategic Partnerships

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6 hours ago

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October 6, 2024

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Middle East and North Africa’s largest fintech show to welcome innovative game-changers and industry leaders from the global fintech community.

Dubai, United Arab Emirates, 6th October 2024, ZEX PR WIRE, Fintech Surge, the Middle East and North Africa’s largest fintech event, will take place at Dubai Harbour from 13-16 October 2024. As an integral part of Expand North Star, powered by GITEX GLOBAL, the fourth edition is set to attract over 100 exhibitors, more than 1,200 investors, and 120-plus speakers from over 70 countries. The event solidifies its position as the premier destination for fintech thought leadership, strategic partnerships, and innovation across the region.

As the UAE continues to cement its role as a global fintech hub, Fintech Surge 2024 arrives at a pivotal time. The UAE’s fintech market is projected to grow from USD 3.16 billion in 2024 to USD 5.71 billion by 2029, driven by a progressive regulatory environment and the rapid adoption of digital banking solutions. Last year, the fintech sector saw a remarkable 92% surge in funding, further elevating the UAE as a powerhouse of innovation in MENA’s fintech landscape.

“Fintech Surge is where the world’s fintech entrepreneurs come to trade in innovation. As the UAE continues to lead in digital transformation, this year’s edition will welcome international companies at the forefront of embedded finance, autonomous finance, and digital currencies, to forge partnerships with technology giants and large enterprises, and shape the future of finance,” said Peter Brady, Associate Vice President at Dubai World Trade Centre.

The event will spotlight critical trends shaping the future of finance, such as digital banking, fintech investment, and the growing collaboration between banks and fintechs. The ‘Future of Money’ conference will cover key themes, including fintech investing, digital banking, and SME Elevate track. As the financial world increasingly shifts toward digital transactions, e-wallets and cashless payment systems are transforming the global landscape. In the panel discussion ‘Rock, Paper, Cashless,’ Asim Chohan, COO at Morgan Stanley USA, will join other experts to explore the implications of a cashless society and its future impact.

The SME Elevate track will feature discussions on empowering small and medium-sized enterprises through fintech, including the Conversation Circle titled ‘Cool Cash—Future Trends in Lending, Microfinance, and Investments.’ Speakers such as Ibrahim Abdel Rahim, Co-founder of Moonbase Capital (Spain), and Chérifatou Ibrahima Agoumo, Regional Innovation and Technology Advisor at CARE USA, will examine how fintech innovation is driving economic growth for SMEs and individuals.

Other sessions will focus on emerging financial technologies, including open banking, embedded finance, and the transformational role of AI in banking. The rise of stablecoins, Central Bank Digital Currencies (CBDCs), and sustainable finance models will also be explored, as the fintech sector continues to innovate while addressing challenges in cybersecurity and regulatory compliance.

With a powerful programme featuring global fintech giants alongside a vibrant start-up community, Fintech Surge will be the essential meeting point for those looking to shape the financial ecosystems of tomorrow. The event will serve as a launchpad for start-ups and innovators, offering a unique opportunity at Demo Day to showcase live prototypes that push industry boundaries. These solutions will highlight how fintech is creating faster, more convenient, and secure ecosystems to meet the growing demands of today’s digital consumers.

Sponsors and exhibitors for the 2024 edition include major industry players such as Codego, Geidea, ADIB Bank, WIO Bank, and pavilions by Fintech Lithuania, Hong Kong, and London & Partners. More information can be found at www.fintechsurge.com.

Press Registration: Click Here

About Fintech Surge

Fintech Surge is the most sought after gathering for the global fintech industry. Capitalising on Dubai’s pioneering status as a leading location for fintechs, it is the foremost platform where international finance and technology players meet to create limitless opportunities. More than 1,200 investors, 150 exhibitors and more than 100 speakers from more than 70 countries will gather to chart the way forward and inspire industry-wide transformation. The fourth edition of Fintech Surge will take place from 13-16 October 2024 alongside GITEX GLOBAL, uniting the global community at the iconic Dubai Harbour. It is co-located with GITEX IMPACT, Expand North Star, Future Blockchain Summit and Marketing Mania.

Expand North Star

Expand North Star 2024, the world’s largest event for start-ups and investors, will bring together leading founders, VCs, tech innovators, and ecosystem enablers to the Dubai Harbour, taking place from 13-16 October 2024. Hosted by the Dubai Chamber of Digital Economy and organised by Dubai World Trade Centre, Expand North Star features four co-located events: GITEX IMPACT, Fintech Surge, Future Blockchain Summit, and Marketing Mania. This 9th edition will welcome over 1,800 global startup exhibitors, 1,200 investors, and 250 speakers from 100 countries. The show is inspired by the world largest tech show, GITEX GLOBAL, which will take place from 14-18 October 2024, at Dubai World Trade Centre.

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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