Press Release
Sector Spotlight: Orphan Drug Developers With Significant Upside
–News Direct–
The biotech sector is finally beginning to recover following a two year stretch of underperformance that was largely driven by rising interest rates and other macro factors. Biotech has a track record of strong recoveries, with the sector typically seeing double-digit gains after a downturn. This is something investors shouldnt ignore.
This recent turnaround can be credited to a robust increase in fundraising efforts and an uptick in IPOs, reaching levels not seen since the peak of the mid-pandemic market boom.
According to the Financial Times, drug developers raised $6 billion in equity capital markets in January, the largest total since February 2021 a period when biotech stocks hit their all-time high. Moreover, the SPDR S&P Biotech ETF (XBI) returned 28.7% over the past six months alone, clearly illustrating investors' rising confidence in the biotech rebound.
Identifying biotech stocks with the potential to deliver superior returns is no easy feat. There are specific milestones that companies can achieve to signal positive momentum to investors. For example, smaller biotech companies may have received the nod from regulatory authorities such as the FDA, or new breakthroughs from clinical trials, to offer a compelling investment opportunity.
With that in mind, two stocks that investors should consider looking at are Cardiol Therapeutics (NASDAQ:CRDL) (TSX:CRDL) and Kiniksa Pharmaceuticals (NASDAQ:KNSA).
Cardiol Therapeutics lead product is CardiolRx, a small molecule therapy that appears on track to bring major disruption to the pericarditis market.
CardiolRx received a vote of confidence as it was granted Orphan Drug Designation (ODD) by the FDA for the treatment of pericarditis back in February, illustrating the potential of the drug. Apart from providing a seven-year term of market exclusivity upon final FDA approval, the ODD also positions Cardiol Therapeutics (NASDAQ:CRDL) (TSX:CRDL) to be able to leverage a wide range of financial and regulatory benefits, including government grants for conducting clinical trials, waiver of expensive FDA user fees, and certain tax credits.
The U.S. Orphan Drug Act is intended to assist and encourage companies to develop safe and effective therapies for the treatment of rare diseases and disorders, defined as one that affects fewer than 200,000 people in the U.S. There are approximately 160,000 cases of recurrent pericarditis in the U.S. annually, which includes 38,000 cases with a recurrence. Having secured FDA approval, Cardiol Therapeutics is an exemplary company likely to attract biotech investors seeking assurance in smaller firms.
While the stock had a significant rally on the backdrop of this news and continues to show strength, we believe that there is still potential for further upside.
Cardiol Therapeutics (NASDAQ:CRDL) (TSX:CRDL) is expected to release topline data in June for its Phase 2 MAvERIC-Pilot clinical trial, which if positive, could unlock significant shareholder value. Several analysts have already indicated that they are highly optimistic that the data could be a catalyst, with one analyst noting that CardiolRxs potential to be a safe, new approach to RP (recurrent pericarditis) treatment is underappreciated.
CardiolRx stands out when compared to the only FDA-approved therapy because it is administered orally and expected to be offered as a first-line therapy for pericarditis, opening it up to an even bigger opportunity as it could be prescribed at the first occurrence.
Orphan drugs have become lucrative business opportunities because these drugs command premium drug pricing, with the average price for an orphan drug at $32,000 per year per patient according to a 2021 study published in the journal Rare Diseases & Journal of Orphan Drugs.
That could explain why analysts who have been tracking CRDL are so bullish on the stock. For instance, Joe Gantoss of Chimera Research Group says he wont be surprised to see Cardiols price break past the 3-year high at $4.96, while analyst Vernon Bernardino of H.C. Wainwright & Co. reiterated their Buy rating and issued a $9.00 price target.
That would imply that Cardiol Therapeutics (NASDAQ:CRDL) (TSX:CRDL) has a potential upside of about 300% from its current share price.
Kiniksa Pharmaceuticals (NASDAQ:KNSA) offers some insight into the revenue potential of an orphan drug that treats recurrent pericarditis.
So far, KNSA has had a great run, gaining about 36% over the past year and trading at about $18.00 per share despite challenges in the sector. It is currently valued at $1.3 billion. Kiniksas portfolio of assets includes ARCALYST, the first and only FDA-approved therapy for recurrent pericarditis.
For some context, the FDA granted Breakthrough Therapy designation to ARCALYST for recurrent pericarditis in 2019; the FDA granted Orphan Drug exclusivity to ARCALYST in March 2021 for the treatment of recurrent pericarditis and a reduction in the risk of recurrence in adults and pediatric patients 12 years of age and older. The European Commission granted Orphan Drug Designation to ARCALYST for the treatment of idiopathic pericarditis in 2021.
Sales of ARCALYST were $38.5 million in 2021; $122.5 million in 2022; $233.2 million in 2023 further reaffirming the massive revenue potential for treating recurrent pericarditis. For the first quarter of 2024, ARCALYST sales were $78.9 million representing 85% year-over-year growth.
Furthermore, since its launch in April 2021, approximately 2,000 prescribers have written ARCALYST prescriptions for recurrent pericarditis, illustrating the massive demand for effective recurrent pericarditis therapies.
Going forward, Kiniksa anticipates that it will bring in between $370 million and $390 million in 2024, up from the earlier guidance of $360 million to $380 million. The revised outlook represents roughly 63% year-over-year growth at the midpoint.
Disclaimers: RazorPitch Inc. "RazorPitch" is not operated by a licensed broker, a dealer, or a registered investment adviser. This content is for informational purposes only and is not intended to be investment advice. The Private Securities Litigation Reform Act of 1995 provides investors a safe harbor in regard to forward-looking statements. Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, goals, assumptions, or future events or performance are not statements of historical fact may be forward looking statements. Forward looking statements are based on expectations, estimates, and projections at the time the statements are made that involve a number of risks and uncertainties which could cause actual results or events to differ materially from those presently anticipated. Forward looking statements in this action may be identified through use of words such as projects, foresee, expects, will, anticipates, estimates, believes, understands, or that by statements indicating certain actions & quote; may, could, or might occur. Understand there is no guarantee past performance will be indicative of future results. Investing in micro-cap and growth securities is highly speculative and carries an extremely high degree of risk. It is possible that an investors investment may be lost or impaired due to the speculative nature of the companies profiled. RazorPitch has been retained and compensated by Cardiol Therapeutics to assist in the production and distribution of content related to CRDL. RazorPitch is responsible for the production and distribution of this content. It should be expressly understood that under no circumstances does any information published herein represent a recommendation to buy or sell a security. This content is for informational purposes only, you should not construe any such information or other material as legal, tax, investment, financial, or other advice. Nothing contained in this article constitutes a solicitation, recommendation, endorsement, or offer by RazorPitch or any third party service provider to buy or sell any securities or other financial instruments. All content in this article is information of a general nature and does not address the circumstances of any particular individual or entity. Nothing in this article constitutes professional and/or financial advice, nor does any information in the article constitute a comprehensive or complete statement of the matters discussed or the law relating thereto. RazorPitch is not a fiduciary by virtue of any persons use of or access to this content.
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View source version on newsdirect.com: https://newsdirect.com/news/sector-spotlight-orphan-drug-developers-with-significant-upside-473277125
RazorPitch CRDL, KNSA
COMTEX_453280304/2655/2024-06-03T07:03:00
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
To keep up with the demands of this dynamic market, Lotradecoin Trading Center has introduced a groundbreaking solution: the AI-Powered Intelligent Trading Assistant. This state-of-the-art tool is set to transform the trading experience by empowering users with smarter, faster, and more secure trading capabilities.
United States, 22nd Nov 2024 – The cryptocurrency landscape is evolving at an unprecedented pace, driven by continuous advancements in technology. To keep up with the demands of this dynamic market, Lotradecoin Trading Center has introduced a groundbreaking solution: the AI-Powered Intelligent Trading Assistant. This state-of-the-art tool is set to transform the trading experience by empowering users with smarter, faster, and more secure trading capabilities.
Smarter Decisions with Advanced AI
The Intelligent Trading Assistant leverages cutting-edge artificial intelligence to provide users with a competitive advantage. By analyzing historical market data, tracking real-time price fluctuations, and synthesizing insights from multiple sources, the tool offers personalized trading strategies tailored to individual goals.
What sets this assistant apart is its ability to deliver predictive analytics. It identifies market trends, forecasts potential price movements, and suggests optimal entry and exit points. Unlike conventional tools that rely on static data, Lotradecoin’s solution continuously adapts to market dynamics, ensuring traders make informed decisions even in volatile conditions.
Additionally, the assistant’s real-time monitoring capabilities enable users to respond to market changes with speed and accuracy. This rapid adaptability helps minimize risks and maximize opportunities, making it an indispensable tool for traders seeking to optimize their strategies in a competitive environment.
Unmatched Security for Peace of Mind
While enhancing trading intelligence, Lotradecoin Trading Center has also prioritized security. The AI Assistant operates within a robust, multi-layered security framework designed to protect user accounts and assets from potential threats. Key features include:
Two-Factor Authentication: Adds an extra layer of protection to user accounts.
Real-Time Security Monitoring: Ensures transactions occur within a secure environment, mitigating risks from cyberattacks.
Data Encryption Protocols: Safeguard sensitive user information from unauthorized access.
These measures underscore Lotradecoin’s commitment to providing a safe trading environment, allowing users to focus on their investments without worrying about security breaches.
Pioneering the Future of Crypto Trading
The AI-Powered Intelligent Trading Assistant is more than just a tool; it represents Lotradecoin’s vision for the future of cryptocurrency trading. With automation and intelligence at its core, the platform is setting new benchmarks for user-centric solutions.
Recognizing the growing need for accessible technology, Lotradecoin is actively engaging with the global crypto community. The company plans to host a series of webinars, tutorials, and live demonstrations in the coming months. These initiatives aim to educate users about the assistant’s features, offering hands-on experience and practical insights to maximize its benefits.
Lotradecoin’s efforts to build an informed and empowered trading community highlight its dedication to inclusivity and innovation. By making advanced tools approachable for all skill levels, the platform is poised to attract a diverse user base.
A Commitment to Continuous Innovation
The introduction of the AI-Powered Intelligent Trading Assistant marks the beginning of an ambitious roadmap for Lotradecoin Trading Center. The company plans to further integrate artificial intelligence, blockchain technology, and big data analytics into its offerings, continually refining the user experience.
As the cryptocurrency market evolves, Lotradecoin Trading Center remains committed to staying ahead of industry trends. Its forward-thinking approach ensures that traders, whether beginners or seasoned professionals, have access to cutting-edge tools designed to enhance their success.
Media Contact
Organization: Lotradecoin
Contact Person: Julien Moreau
Website: https://lotradecoin.net/
Email: Send Email
Country: United States
Release Id: 22112420336
The post Lotradecoin Trading Center: AI Revolution in Crypto appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.
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Press Release
DexWin, World’s First Licensed Decentralized Crypto Bookmaker, Introduces Gasless Betting on Polygon
Nicosia, Cyprus, 22nd November 2024, ZEX PR WIRE, The DexWin platform (the first licensed decentralized crypto bookmaker) and its team have created a decentralized betting platform on the Polygon network. The project brings an enhanced betting experience to users, with faster transactions, 0 gas fees, and increased overall reward and freebet system to the players.
DexWin, as the world’s first licensed decentralized crypto bookmaker, is determined to shake up the traditional sports betting industry. The first licensed web3 sportsbook to offer unique benefits such as boosted odds, bonuses, and a fully gasless betting option. One step sign up, makes it easy for non crypto natives (or newbies) to also get betting with the best odds.
The World’s First Decentralised Crypto Bookmaker: The Features That Make DexWin a Top Player
DexWin is the very first licensed, fully decentralized crypto betting platform, offering its users a completely gasless experience. This feature gives it an edge from the rest of the conventional betting platforms. In fact, users will have full control over their betting money at all times.
DexWin appeals directly to users wishing to place a bet from any corner of the world. This is possible through seamless social login and instant withdrawals with no limits. Since boosted odds eliminate fees for top players, DexWin offers some of the best odds in the business.
In reality, what sets DexWin apart is also the monthly cashback bonus and $DWIN/$AZUR airdrops for all players. These could be used further in boosting odds and earnings on this platform, making it even more attractive for avid sports bettors.
The project merges the Web3 benefits with social logins, Ramp, and Bridge to easily deposit and withdraw with no KYC hassles. For users desiring enhanced, more interactive ways to bet, DexWin has an AI betting assistant. Furthermore, the project’s Telegram bot is an added core feature for this platform.
However, the utility token of DexWin ($DWIN) is what really makes it stand out as a decentralized project. Owning $DWIN gives players multiple benefits and utilities, which will be shared by the team as they near TGE of $DWIN.
Experiencing the Future of Sports Betting on DexWin – World’s First Licensed Decentralized Crypto Sports Betting Platform
DexWin is a platform that gives users a chance to bet on any kind of event. DexWin gives a wide array of options where users can choose between traditional sports like football, tennis, basketball etc. A set of emerging favorites includes eSports and world events as well.
Its intuitive menu gives out everything one might need. The accessible pages include “Promos,” “Cashbacks,” and more. The whole system relies on transparency thanks to the “My Bets” feature. Here, users can keep track of both past and ongoing bets in one place, and show off their betslips on Twitter or any social media, to earn more $DWIN points.
Another thing unique about DexWin is its bonus system, whereby they reward users for using their platform. Monthly cashbacks range from 1.3% up to 1.7%, depending on how much users wager and their user levels which is much greater than the top centralized crypto sports betting platforms currently.
Notably, commitment to fairness by DexWin goes into boosted odds. With this feature, DexWin removes VIG and gives select users the ability to bet, using USDT for boosted best odds. Hence, the platform is allowing users to bet fairly without the added cost of VIG.
Other additional features involve (but are not limited to):
- Airdrops
- $AZUR for airdrops and token claiming in the future
- Leaderboards to keep track of user activities and levels
- A VIP program for monthly cashback bonuses
- Picks where users go through other public action bets or replicate them.
About DexWin – The World’s First Licensed Decentralised Crypto Bookmaker
To summarize, DexWin is a top decentralized betting platform that is changing the landscape of sports betting. Founded by a team of experienced professionals, DexWin offers a unique experience to its users. Features like gasless betting, boosted odds, and bonuses are certainly the main catch of the platform.
Even as a young project, DexWin has some impressive stats to share with the public. With over $15M in payouts, roughly 30,000 placed bets, and over 5,000 bettors, many are talking about this initiative.
The platform utilizes the Polygon network for faster transactions and zero gas fees compared to new age web3 or any other traditional sportsbooks.
On DexWin, bettors can use USDT (a stablecoin pegged to the US dollar) to place bets on various sports events. This provides low volatility while still benefiting from all that blockchain technology has to offer.
There are some upcoming features coming to this project that will create even more traction among existing and upcoming users. For instance, a decentralized crypto casino, buy-and-sell world events or any events of the users’ choice are among the main highlights to expect.
Anyone curious about trying their hand at betting can visit the official DexWin website. Moreover, the social pages below are actively posting updates and news about the platform.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
MemeSparks.com Pioneers the World’s First Web3 and AI Text-to-Video Fusion, Powered by $MEMEKS and SOL
Taipei, Taiwan, 22nd November 2024, ZEX PR WIRE, MemeSparks.com proudly unveils a revolutionary platform, marking a significant milestone as the first in the world to seamlessly integrate Web 3.0 technologies with AI-driven text-to-video capabilities, all powered by transactions in $MEMEKS and SOL. This pioneering service is designed to transform the way content is created, specifically catering to the needs of creators and memecoin developers, enhancing their digital footprint and marketing prowess in an unprecedented manner.
This groundbreaking platform offers an ecosystem where the power of decentralization meets the innovation of AI video generation, allowing for the swift conversion of text into dynamic visual content. Users, including creators and especially those engaged in Solana memecoin development, can now utilize an AI-powered marketplace to generate videos that resonate with the ever-changing memecoin trends. By accepting $MEMEKS or SOL for transactions, MemeSparks.com not only simplifies the process but also embeds the platform deeply within the Web3 economy.
At the core of MemeSparks.com’s operations is a commitment to transparency and community governance. Every text-to-video AI package purchased with $MEMEKS or SOL contributes to the “Community Wallet.” This wallet, under the stewardship of the developers, finances the platform’s operational costs, with a pledge for monthly transparency reports detailing its use. From this wallet, the platform’s sustainability is supported in several ways:
Developers receive a monthly 10% share for their efforts in maintaining and expanding the platform’s capabilities, project management, and marketing initiatives. Additionally, 20% of the wallet’s resources are allocated to ensure the platform’s operational integrity, covering essential expenses like domain maintenance, security measures, and technological updates. However, the democratic essence of Web3 is most vividly realized in the governance model, where 60% of these funds are open for decision-making through a Decentralized Autonomous Organization (DAO). Here, $MEMEKS holders can vote on pivotal aspects like marketing campaigns, partnership initiatives, and the strategic burning or airdropping of tokens, directly influencing the ecosystem’s evolution.
This governance structure embodies the spirit of decentralization, giving token holders a direct say in the platform’s strategic direction. The process is inclusive, with the Council of Creators elected to propose and oversee major decisions, while the General Assembly, comprising all token holders, votes on these proposals. This dual-layered governance not only fosters an active community but also ensures that the platform evolves in line with its users’ collective vision.
The integration of AI for video synthesis and visual storytelling is not just about technological advancement; it’s about creating a new paradigm for content creation in the memecoin space. MemeSparks.com, by being the first to merge Web3 with text-to-video AI technology, offers a novel utility through $MEMEKS, empowering users to convert their creative ideas into engaging visual narratives with unparalleled ease and immediacy.
For those intrigued by this innovative venture, further exploration can be done at the MemeSparks.com official website, with continuous updates and community engagement available through their social channels on X (Twitter) and Telegram.
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Lotradecoin Trading Center: AI Revolution in Crypto
DexWin, World’s First Licensed Decentralized Crypto Bookmaker, Introduces Gasless Betting on Polygon
MemeSparks.com Pioneers the World’s First Web3 and AI Text-to-Video Fusion, Powered by $MEMEKS and SOL
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