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PathAI Announces Research Presentations at the 2024 AACR Annual Meeting

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–News Direct–

PathAI, Inc., a leading AI-powered precision pathology company, today announced it will present research from its portfolio of oncology products at the AACR Annual Meeting on April 7-10, 2024, in San Diego, CA. The research demonstrates how machine learning models developed to characterize the tumor microenvironment (TME) from routine hematoxylin and eosin (H&E)-stained whole slide images (WSIs) can be used to advance biomarker development and precision medicine strategies.

The presentations include new research leveraging PathAIs pan-tumor foundation models and its commercially available product, PathExplore1, to identify key histologic features associated with molecular signatures and patient response to therapy. Highlights:

  • Researchers deployed PathExplore on HNSCC and NSCLC samples to characterize the cell and tissue composition of the tumor microenvironment, as well as compute immune phenotypes directly from H&E WSI. (Poster #905)
  • Researchers from Incendia Therapeutics developed a continuous scoring method for Discoidin Domain Receptor 1 (DDR1), which revealed widespread immune exclusion in tumors based on the spatial distribution of lymphocytes, CD8+ T cells, and CD45+ immune cells from H&E and mIF images. DDR1 is highly expressed in epithelial cancers and has been implicated in tumor growth, invasion, and lack of response to therapy. The immune exclusion score correlates with DDR1 mRNA and protein expression. The study provides additional insight into the role of DDR1 in human cancers and may be useful in selecting indications and stratifying patients for DDR1-targeted therapies. (Poster #2916)
  • Using unsupervised learning driven by PathExplores features and a novel collagen fiber detection imaging technology, researchers discovered three distinct phenotypes of cancer associated stroma (CAS) that had distinct patterns of association with survival and gene expression signatures. Two of them were enriched in collagen fiber density as well as in density of fibroblasts, while the third phenotype had the highest density of immune cells, providing a categorization of different types of CAS-tumor interaction that may be useful for patient stratification. (Poster #4912)
  • Using AI-powered models from PathAI, Foundation Medicine researchers investigated digital pathology TME features of immunotherapy outcomes among NSCLC patients within a real-world dataset from the Flatiron Health-Foundation Medicine Clinico-Genomic Database. These results indicate that the composition of the TME assessed via digital pathology may have utility in identifying NSCLC patients who will respond to first-line immune checkpoint inhibitors beyond the established immunotherapy biomarkers. (Poster #4969)
  • In collaboration with EMD Serono, AI-powered TME models from PathAI were used to analyze H&E WSI of NSCLC from a randomized Phase 3 trial directly comparing two immunotherapies. Researchers compared cell abundance features with gene expression data from the same samples and found that immune and stromal cell abundance features were associated with expression of genes in relevant cellular pathways, confirming the biological relevance of our cellular features. In analyzing the features alongside the clinical data from the retrospective study, researchers identified candidate prognostic immunotherapy biomarkers. (Poster #6179)
  • Researchers from Incendia Therapeutics illustrated that morphologic features derived from H&E images using PathExplore can be effective predictors of CD8-defined immune exclusion, providing an option for patient stratification by immune phenotype using widely available H&E images. The features and direction of association align with prior knowledge of the mechanism or manifestations of immune exclusion or infiltration in the TME, including the relative density of lymphocytes in tumor and stroma. (Poster #7392)
  • PathAIs pan-tumor foundation models were used to identify tissue regions and cell types on H&E WSI to quantify tumor purity across multiple tumor types. Model-derived tumor purity estimates were compared to three orthogonal molecular methods of purity and found to correlate across disease indications. These results provide evidence of how AI can improve the efficiency of molecular testing and enhance precision diagnostic strategies. (Poster #7402)

Follow PathAI on LinkedIn and X for more updates from #AACR24 and visit us in person at booth #1549.

Abstract #

Title

Collaborator

Product

Abstract #905

April 7, 2024, 1:30 PM – 5:00 PM

ML quantification of tumor-Infiltrating lymphocytes distinguishes immune-phenotypes and reveals phenotypic heterogeneity

AbbVie

PathExplore

Abstract #2916

April 8, 2024, 1:30 PM – 5:00 PM

Discoidin Domain Receptor 1 (DDR1) expression is associated with degree of immune exclusion across epithelial tumors

Incendia Therapeutics

PathExplore

Abstract #4912

April 9, 2024, 9:00 AM – 12:30 PM

Unsupervised detection of stromal phenotypes with distinct fibrogenic and inflamed properties in NSCLC

N/A

PathExplore

Abstract #4969

April 9, 2024, 9:00 AM – 12:30 PM

Investigating digital pathology tumor microenvironment (TME) biomarkers for immunotherapy (IO) response stratification in patients with advanced non-squamous NSCLC

Foundation Medicine

PathExplore

Abstract #6179

April 9, 2024, 1:30 PM – 5:00 PM

Machine learning (ML)-spatial quantification of the tumor microenvironment (TME) identifies differences associated with response to bintrafusp alfa (BA) vs pembrolizumab (PEM) treatment in the Phase 3 INTR@PID Lung 037 study

EMD Serono

PathExplore

Abstract #7392

April 10, 2024, 9:00 AM – 12:30 PM

Machine learning-based identification of H&E-derived morphologic features associated with CD8+ T cell immune exclusion

Incendia Therapeutics

PathExplore

Abstract #7402

April 10, 2024, 9:00 AM – 12:30 PM

Foundation AI models predict molecular measurements of tumor purity

N/A

1PathExplore is For Research Use Only. Not for use in diagnostic procedures.

About PathAI

PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and laboratory use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases.

PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com.

Contact Details

SVM Public Relations and Marketing Communications

Maggie Naples

+1 401-490-9700

pathai@svmpr.com

Company Website

https://www.pathai.com/

View source version on newsdirect.com: https://newsdirect.com/news/pathai-announces-research-presentations-at-the-2024-aacr-annual-meeting-566770794

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Step into a World of Strength and Survival with ‘The Eyes From Above’

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Uncover The Secrets Of The Eyes From Above: Jabari Lamb Invites Readers On An Inspiring Journey Of Triumph, Survival, And Self-Discovery

Ride on a journey of power, survival, and the unbreakable human spirit in the new novel by Jabari Lamb titled “The Eyes From Above.” A Nationwide Release will thereafter tell the story of family, perseverance, and reclaiming one’s identity in a world fraught with danger and hostility.

Track the life of Connie, fighting his way through dangerous waters to uncover long-buried truths about his family’s past, as he evades sinister forces who are determined to stop him at every step. In Charleston, South Carolina, this is the story peeling historical trauma, mythical elements, and an African sense of roots into a bewitching tapestry of history, fantasy, and raw emotion.

There’s that richness of culture and heritage alive through the eyes of his Gullah Geechee perspective: all the trials and triumphs of the African diaspora. He spent time abroad in South Africa, exploring other pockets of the African continent; he weaves a very personal, detailed narrative of African traditions and powerful ancestral connections that should speak to readers from every part of this world.

For high drama or soul-stirring histories, be sure to read “The Eyes from Above” to question what truth is and what is in memory. This book is available in bookstores all over the country and in stores online.

About the Author

A bold, new voice in literature, Jabari Lamb blends history and mythology and his Gullah Geechee heritage in stories hard to forget. This impressive young writer’s novel, The Eyes From Above, explores African roots and displacement based on his journey learning about the Gullah Geechee people, the history of African-Americans, and his trip to South Africa. A voice unique unto his own, Jabari extends the invitation to the reader to consider the fluidity of memory and identity and, indeed, the truth. The Eyes From Above makes its wonderful debut into the literary world.

Media Contact:

Contact Person: Jabari Lamb

Email: Jabarilamb1847@gmail.com

Phone: 770-580-3190

Website: Jabarilamb.com

City: Atlanta

State: Georgia

Country: United States

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Yijin Hardware Delivers High-Quality Sheet Metal Fabrication Services Worldwide

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United States, 17th Oct 2024, Yijin Hardware, a key player in precision CNC machining, has announced the global expansion of its sheet metal fabrication services. This development is aimed at supporting industries worldwide with high-quality, custom-engineered metal components. By extending services to new markets, Yijin Hardware strengthens its position as a reliable manufacturing partner for sectors that require precise, durable parts, such as automotive, aerospace, and electronics.

Yijin Hardware Delivers High-Quality Sheet Metal Fabrication Services Worldwide

Yijin Hardware has a long history of providing precision-engineered components, and its expansion into international markets reflects the company’s response to rising demand for reliable sheet metal fabrication services. The new offerings will include laser cutting, metal bending, welding, and a variety of other fabrication processes, designed to accommodate a wide range of industrial applications.

“Precision and quality have always been at the heart of Yijin Hardware’s operations,” said Gavin Yi, CEO of Yijin Hardware. “The expansion of sheet metal fabrication services is a natural progression in the company’s growth, enabling access to more industries worldwide that require high-performance metal components for their operations.”

The sheet metal fabrication sector has seen increasing demand as industries move towards more complex and custom-engineered solutions. Yijin Hardware’s global expansion is positioned to meet these growing needs by offering scalable services that are capable of handling both small-scale production and larger manufacturing runs. The company’s advanced facilities are equipped with the latest machinery, ensuring that each part meets precise specifications and high-quality standards.

Yijin Hardware has also invested heavily in upgrading its production infrastructure to support the increased demand from international clients. Enhancements in laser cutting, welding, and assembly operations have been key factors in enabling the company to offer a more diverse set of services globally. The ability to handle custom and high-volume orders without compromising on quality is a cornerstone of Yijin Hardware’s service offerings.

Yijin Hardware Delivers High-Quality Sheet Metal Fabrication Services Worldwide

“Looking ahead, Yijin Hardware is committed to further advancing its manufacturing capabilities,” Gavin Yi added. “There are plans to introduce more cutting-edge technologies that will enhance both CNC machining and sheet metal fabrication services. These advancements will ensure the company remains well-positioned to address the evolving needs of industries in the future.”

Yijin Hardware’s expanded services will cater to industries with a need for complex, high-precision components, including automotive parts, aerospace structures, and electronic enclosures. With a focus on maintaining strict quality control throughout the production process, the company aims to provide solutions that meet exacting industry standards.

As part of its expansion strategy, Yijin Hardware continues to emphasize innovation and efficiency. These principles are expected to guide the company’s future developments as it explores new manufacturing technologies and methods. The expansion also supports the company’s vision of being a global leader in precision engineering.

For further information about sheet metal fabrication services, please contact Yijin Hardware at +1 626 263 5841 or via email at yijing@yijinsolution.com. 

Media Contact

Organization: Yijin Hardware

Contact
Person:
Gavin Yi

Website:

http://yijinsolution.com/

Email:

yijing@yijinsolution.com

Country:United States

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Press Release

Yijin Hardware Offers Global CNC Machining Services from China

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United States, 17th Oct 2024, Yijin Hardware, a well-established provider of custom CNC machining services, has announced its expansion into global markets. The company, recognized for its precision manufacturing capabilities, aims to support international businesses in industries such as aerospace, automotive, electronics, and medical with tailored CNC solutions. This move comes as industries worldwide increasingly require high-quality, custom-manufactured components to meet modern production needs.

Yijin Hardware Offers Global CNC Machining Services from China

Yijin Hardware’s decision to extend its services beyond China reflects its commitment to addressing the needs of a broader range of industries. With years of experience in CNC machining, the company has developed a reputation for delivering reliable and precise parts to a diverse set of clients. The expansion will provide industries worldwide with access to Yijin Hardware’s capabilities, backed by advanced technology and stringent quality control.

Gavin Yi, CEO of Yijin Hardware, commented on the expansion: “This move into international markets represents a significant milestone. Yijin Hardware has always emphasized precision and reliability, and this expansion allows those same standards to be brought to clients around the world. Whether the project involves a small batch of components or a large production run, the company is prepared to meet the exacting standards required by global industries.”

Operating from its facilities in Shenzhen, Yijin Hardware manages the full lifecycle of production, from initial design to final inspection. This comprehensive approach ensures that each project is carefully monitored to meet specific client requirements. Yijin Hardware’s ability to offer customized machining solutions is seen as a key factor in its growth, particularly as companies increasingly seek specialized components for complex applications.

Previously focused primarily on the domestic market in China, Yijin Hardware’s expansion aims to deliver the same level of precision and service to international clients. By positioning itself as a global CNC machining provider, the company plans to strengthen relationships with existing partners while establishing new connections in other regions.

Yijin Hardware Offers Global CNC Machining Services from China

This global expansion comes at a time when demand for CNC machining services is rising due to the increasing complexity of product designs and the need for enhanced precision in manufacturing. As industries continue to evolve, CNC machining remains crucial to ensuring that parts meet exact specifications. Yijin Hardware has embraced this role through continuous investment in advanced equipment and machining techniques.

Looking ahead, Yijin Hardware is also focused on the future of manufacturing and its impact on sustainability. The company plans to explore new methods that reduce material waste and promote more efficient production processes. According to Gavin Yi, “As the company expands globally, attention is focused not only on immediate goals but also on contributing to long-term sustainable manufacturing. CNC machining plays a critical role in reducing waste and improving production efficiency. Yijin Hardware is committed to finding ways to make processes more environmentally friendly, to become a leader in both precision and sustainability.”

Yijin Hardware’s entry into global markets signals a broader shift in its strategy, focusing on serving a more diverse range of industries with its expertise in CNC machining. By offering international clients access to its advanced manufacturing solutions, the company aims to become a trusted partner for businesses looking to streamline production with high-quality, custom-manufactured parts.

For more information about Yijin Hardware’s global CNC machining China, inquiries can be directed via phone at +1 626 263 5841 or by email at yijing@yijinsolution.com.

Media Contact

Organization: Yijin Hardware

Contact
Person:
Gavin Yi

Website:

http://yijinsolution.com/

Email:

yijing@yijinsolution.com

Contact Number: 16262635841

Country:United States

The post Yijin Hardware Offers Global CNC Machining Services from China appeared first on
Brand News 24.
It is provided by a third-party content
provider. Brand News 24 makes no
warranties or representations in connection with it.

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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