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Oncotelic Therapeutics (OTC: OTLC) Inks Deal With Mosaic ImmunoEngineering To Sell Clinical-Stage Necroptosis Cancer Therapy Assets

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–News Direct–

By Faith Ashmore, Benzinga

The global retinoblastoma treatment market size was estimated to be $2.62 billion in 2023 and is expected to reach $4.20 billion by 2034 with a CAGR of 4.38% over 2024-2034. Rising incidence of retinoblastoma, early diagnosis and treatment, increasing healthcare expenditure, growing awareness of retinoblastoma treatment options, development of new treatments and government initiatives will drive the markets growth.

Recently, the FDA granted accelerated approval to Iovance Biotherapeutics (NASDAQ: IOVA) lifileucel (Amtagvi) to treat inoperable or metastatic melanoma, making it the first and only one-time tumor-infiltrating lymphocyte (TIL) therapy to be greenlighted for solid tumors. Lifileucel is manufactured by collecting and expanding a patients unique T cells from part of their tumor and then infusing them into that patient to fight the cancer.

Oncotelic Therapeutics (OTCQB: OTLC) is looking to develop similar treatment therapies for ocular cancers, including retinoblastoma and uveal melanoma. The technology is named necroptosis therapies.

Oncotelic and Mosaic ImmunoEngineering, Inc. (OTC: CPMV) are developers of necroptosis therapies. The recent approval of TIL cell therapy demonstrates how to manipulate patient immunity against cancer for a lasting cure. However, TIL cell therapy is costly, time-consuming and technologically challenging. Instead of driving TIL cells externally, Necroptosis Cancer Therapies drive innate TILs to the tumor. The key step is the induction of necrotic cell death and activation of death genes, exposing tumor-reactive antigens to initiate an immune response, activating antigen-presenting cells to achieve large-scale antigen presentation, activating T-cells, inducing strong and sustained cytotoxic T lymphocyte responses, and ultimately triggering a TIL antitumor immune effect. Necroptosis Cancer Therapies can use vascular disrupting agents (VDA), in combination with CheckPoint Inhibitors and other IO agents to drive TIL cells to the tumor.

Oncotelic Therapeutics recently announced a binding term-sheet agreement with Mosaic ImmunoEngineering. Under this arrangement, Mosaic will acquire the rights to Oncotelic's clinical-stage necroptosis cancer therapies. These innovative therapeutics disrupt tumor blood flow, leading to immunogenic tumor cell death through the activation of "death receptors" ultimately triggering a potent anti-cancer immune response. As part of the deal, Mosaic will also gain access to Oncotelic's AI technologies for identifying immunotherapy combinations.

"We are very pleased to have this opportunity to bring these clinical stage assets that have promise for the treatment of multiple types of cancer into Mosaic. We anticipate that the initial application of the technology will be in areas with high unmet medical need such as uveal melanoma and retinoblastoma. We look forward to working with the Oncotelic team to advance the program," said Steven King, President and CEO of Mosaic.

As outlined in the binding term sheet, Mosaic will issue $15 million in CPMV shares to Oncotelic upon the execution of the definitive purchase agreement. Additional milestones will enable Oncotelic to earn up to an extra $15 million in CPMV shares. The experienced Mosaic team, with a collective background encompassing more than 30 FDA and worldwide product approvals, will spearhead the advancement of these technologies. Both companies will collaborate closely to ensure the smooth transfer of technologies from Oncotelic to Mosaic, with Oncotelic providing short-term financial support for the program while working together toward achieving short-term and long-term financing goals.

"This will be the second transaction for capitalizing on our assets and building shareholder value. The first being the successful transition of OT-101 to our joint venture (JV) with Dragon Capital Overseas, Limited. The JV is expected to list for an IPO and has been expanding its R&D including the completion of its research and manufacturing facility headquartered in San Diego, California." shared Dr. Vuong Trieu, CEO of Oncotelic.

Pipeline What More To Expect From Oncotelic

Oncotelic has multiple drugs in its pipeline, such as ArtiVeda/ArtiShield, a COVID drug that aims to inhibit the spread of the virus; OT-101 for the treatment of solid tumors with a focus on brain cancer in adults and diffuse intrinsic pontine glioma in children; CA4P, which is intended to be used with Ipilimumab for the treatment of solid tumors with focus on melanoma; Oxi4503 for the treatment of liquid tumors with focus on childhood leukemia; and AL-101, an intranasal drug for the treatment of Parkinson Disease that also targets Erectile Dysfunction and Female Sexual Dysfunction. Oncotelic is looking to develop these drugs using a similar JV structure, which should enhance shareholder values.

With an encouraging recent announcement and an extensive pipeline, Oncotelic may be a company to watch as it continues its endeavors to provide patients with more efficient treatments with fewer side effects.

Featured photo by Olga Kononenko on Unsplash.

Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders.

This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.

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View source version on newsdirect.com: https://newsdirect.com/news/oncotelic-therapeutics-otc-otlc-inks-deal-with-mosaic-immunoengineering-to-sell-clinical-stage-necroptosis-cancer-therapy-assets-350987041

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AIA Labs Introduces AIA Chain: A Game-Changing Blockchain for Financial Transactions

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AIA Labs, a trailblazer in blockchain innovation, has officially launched AIA Chain, a next-generation blockchain platform designed specifically for high-performance financial transactions. Fully compatible with the Ethereum Virtual Machine (EVM), AIA Chain integrates cutting-edge technology with unparalleled speed, scalability, and cost-efficiency, making it a leader in decentralized finance (DeFi), blockchain payments, and Web3 infrastructure.

Why AIA Chain Stands Out in the Crypto Ecosystem

AIA Chain is setting new benchmarks in the crypto and blockchain industries, addressing key challenges such as transaction speed, scalability, cost-efficiency, and regulatory compliance. Its unique features make it a compelling choice for developers, institutions, and users seeking innovative solutions in the rapidly evolving world of blockchain technology, cryptocurrencies, and smart contracts.

With the global digital payments market projected to reach $20 trillion by 2030, AIA Chain is strategically positioned to become a cornerstone of blockchain-based payment infrastructure.

Unrivaled Transaction Speed and Low Fees

AIA Chain is redefining the standards for blockchain payments with:

  • Over 100,000 transactions per second (TPS): AIA Chain surpasses the performance of major blockchains like Ethereum, Binance Smart Chain (BSC), and Solana.
  • Ultra-low transaction costs: At just $0.0002 per transaction, AIA Chain outperforms many leading blockchains, making it ideal for high-frequency use cases such as crypto payments, remittances, and DeFi protocols.
  • Meta-transaction mechanism: AIA introduces this advanced feature to lower the barriers for both developers and users, enhancing usability and adoption.

Built for DeFi, Web3, Gamefi, On-chain AI Agent and Beyond

AIA Chain is fully compatible with Ethereum, enabling seamless migration of projects and smart contracts. This makes it an ideal platform for developers building DeFi apps, NFT marketplaces, metaverse projects, and GameFi ecosystems. The platform’s focus on scalability and interoperability ensures that projects can thrive in a rapidly growing Web3 world.

Key Features of AIA Chain

APoS Consensus Mechanism and ISN Architecture

AIA Chain employs Adaptive Proof of Stake (APoS) and a unique Internet Sharding Network (ISN) architecture. These innovations:

  1. Prevent centralization and whale manipulation, ensuring a fair and secure network.
  2. Increase transaction throughput and enhance the platform’s decentralization.
  3. Drive high network activity, making AIA Chain a dynamic and robust ecosystem.

EVM Compatibility and Developer-Friendly Tools

By being fully compatible with EVM, AIA Chain simplifies project migration from blockchains like Ethereum, Binance Smart Chain, and Polygon. The inclusion of AVM (AIA Virtual Machine) provides developers with advanced tools to build scalable and innovative solutions, enabling smart contract deployment and decentralized application (dApp) development with ease.

Scalability and Layer 2 Solutions

AIA Chain supports Layer 2 scaling solutions and cross-chain interoperability, offering developers the tools to create applications that transcend blockchain silos. These features unlock vast potential for DeFi ecosystems, cross-border crypto payments, and enterprise blockchain solutions.

Focus on Compliance and Institutional Adoption

AIA Chain prioritizes regulatory compliance in global markets, providing a secure and legally compliant environment for both institutional and individual users. This focus positions AIA Chain as a preferred platform for enterprise blockchain adoption, bridging the gap between traditional finance (TradFi) and decentralized finance (DeFi).

Developer and Ecosystem Support

The AIA Foundation actively supports promising projects with funding, technical guidance, global roadshows, and marketing resources. By fostering developer growth, the foundation aims to build a vibrant, innovative ecosystem that accelerates the adoption of blockchain technology and cryptocurrency worldwide.

Transforming the Blockchain Landscape

AIA Chain’s unique combination of speed, affordability, and developer-friendly features positions it as a transformative force in the blockchain industry. Its applications span:

  • DeFi Protocols: Supporting decentralized exchanges (DEXs), liquidity mining, and innovative yield farming strategies.
  • Crypto Payments: Optimized for real-time, low-cost transactions in retail and institutional markets.
  • Gamefi, Ai-Fi, Memecoin, NFT and Web3 Ecosystems: AIA Chain provides a scalable foundation for Gamefi, Ai-Fi, Memecoin, NFTs, metaverse projects, and decentralized governance applications.
  • Enterprise Adoption: With a focus on compliance and scalability, AIA Chain bridges the gap between traditional financial systems and blockchain technology.

About AIA Labs

As the operational backbone of AIA Chain, AIA Labs is committed to fostering a dynamic and inclusive blockchain ecosystem. By providing technical leadership, regulatory insights, and developer support, AIA Labs is empowering a new generation of blockchain applications in DeFi, Web3, and beyond.

Support for Developers:

The AIA Foundation, managed by AIA Labs, offers comprehensive support for promising projects, including funding, technical assistance, and global marketing resources. By lowering barriers to entry, AIA Labs accelerates adoption and innovation within the blockchain space.

Focus on Compliance and Stability:

AIA Labs prioritizes compliance with regulatory frameworks across key global markets, establishing AIA Chain as a reliable platform for institutions and individuals alike, providing a compliant and secure platform for institutions and individuals. This commitment to compliance establishes AIA Chain as a preferred choice for financial applications requiring high-frequency transactions and reliability.

For more information, visit AIA Labs Website.

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Tradeview Markets Shines at Finance Magnates London Summit 2024

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London, UK, 26th November 2024, ZEX PR WIRETradeview Markets proudly stole the spotlight at the Finance Magnates London Summit 2024, a premier two-day event that brought together the biggest names in the financial industry.

With one of the best-looking booths, Tradeview’s presence was unmatched, attracting more attendees than any other exhibitor at the summit.

A Hub of Connection and Innovation
Tradeview´s team made the most of every moment, engaging with industry leaders, networking with professionals from across the globe, and showcasing cutting-edge technological advancements. Visitors at the booth not only experienced the future of trading but also left with exclusive giveaways—caps, ties, pens, and more—making Tradeview’s stands the ultimate destination at the summit.

Unforgettable Experiences and Star Power

In a highlight that wowed attendees, players from the Leicester Tigers men’s and women’s teams were at booth #31 to meet fans and take photos. This unique collaboration underscored Tradeview’s commitment to blending industry excellence with engaging, memorable experiences.

Adding to the excitement, models and influencers brought energy and style the booth, ensuring that Tradeview was a trending topic throughout the summit. From product demonstrations to interactive sessions, the buzz surrounding Tradeview Markets was electric.

A Bright Future for Tradeview Markets
“Tradeview Markets is thrilled to have been such a pivotal part of the Finance Magnates London Summit 2024,” said Tim Furey, CEO at Tradeview Markets. “This event provided an incredible platform for us to connect with the global financial community, showcase our innovations, and highlight what makes Tradeview a leader in the industry. The response was phenomenal, and we’re excited to continue building on this momentum.”

Looking Ahead
Tradeview Markets remains dedicated to pushing boundaries and leading the way in the financial services sector. With the success of the Finance Magnates London Summit 2024, the company is poised for an exciting year ahead, filled with innovation, growth, and continued industry leadership. Additionally, Tradeview Markets will participate in the Traders Fair in Hong Kong on December 14th.

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China-Europe Industrial Innovation Zone: Creating a model zone for China-EU cooperation

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2024 marks the 21st anniversary of establishing a comprehensive strategic partnership between China and Europe, China-EU relations are showing good momentum of consolidation and development. China looks forward to the EU becoming a key partner in pursuing Chinese modernization, sharing opportunities in its vast market, institutional opening-up, and deepening international collaboration.

Wuxi, a core city in the Yangtze River Delta urban agglomeration, has attracted investments from European companies such as AstraZeneca, Bosch, and Siemens since China’s coastal opening up. The city has opened up China-Europe freight train services and direct cargo routes to Europe, fostering deepening economic and trade cooperation—Wuxi High-tech Zone, located in the hinterland of the Yangtze River Delta with convenient transportation links. Since becoming a national high-tech zone in 1992, it has incubated a robust ecosystem of technological innovation, housing numerous postdoctoral workstations, listed companies, and high-tech enterprises. Ranked 4th among China’s top 100 districts for high-quality development and 18th among 177 national high-tech zones, Wuxi High-tech Zone stands out as a beacon of growth.

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In November 2023, the Wuxi China-Europe Industrial Innovation Zone was officially launched.

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As an open window for China-Europe cooperation, the China-Europe Industrial Innovation Zone aims to promote high-level openness, serving as a platform for sharing opportunities globally, a bridge for deepening EU collaboration, and a forefront for innovation in China-Eu partnerships. By the end of 2023, EU countries states had invested in 166 projects in the Wuxi High-tech Zone, with a total investment of €15 billion. In 2023 alone, these projects generated sales revenue of RMB 118.23 billion and contributed RMB 8.18 billion in taxes.IMG_256

Spanning a total planned area of 24.5 square kilometers, the China-Europe Industrial Innovation Zone is situated in the Meicun area of the Wuxi High-tech Zone. The core area covers 7.7 square kilometers, with the initial development area along both sides of Xinhua Road spanning 1.15 square kilometers. Anchored in Meicun Street, the zone aims to become a model for China-Europe cooperation, providing a premium platform for the Wuxi High-tech Zone and the city of Wuxi to strengthen international collaboration. The first phase of construction has already reached the structural topping-off stage and is expected to be completed by March 2025.

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Building on Wuxi High-tech Zone’s solid foundation of international industrial cooperation, the China-Europe Industrial Innovation Zone adheres to a philosophy of integrated development of science, industry, and urbanization. It is actively developing four international cooperation sub-parks: the China-Germany International Cooperation Industrial Park, the China-France International Cooperation Industrial Park, the China-Switzerland International Cooperation Industrial Park, and the China-Israel International Cooperation Industrial Park.

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The China-Europe Industrial Innovation Zone targets an annual output value of RMB 160 billion and tax revenue exceeding RMB 8 billion. It aims to attract at least 30 European “hidden champion” enterprises, including over 10 multinational company headquarters. The zone will construct more than 500,000 square meters of innovation facilities and jointly establish at least three European industrial technology transfer centers. Efforts to attract major China-Europe cooperative projects are being intensified, with key EU-related projects such as Legrand, AML Systems, Schneider Electric, Faurecia, and Siemens accelerating their presence in the zone. The future focus will be on cutting-edge EU technologies and innovations, optimizing industrial structure and layout to position the zone as a leading provincial-level economic development zone, Wuxi High-tech Zone’s preferred industrial destination, and a top-tier international industrial cooperation zone renowned across China and the Yangtze River Delta.

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