Press Release
New Clinical Data Reveals MAIA Biotechnology’s THIO Achieves High Efficacy In Advanced Non-Small Cell Lung Cancer Treatment
–News Direct–
By Mangeet Kaur Bouns
Lung cancer remains the top cause of cancer-related deaths in the U.S., accounting for approximately 20% of all cancer fatalities. The American Cancer Society's projections for 2024 highlight the gravity of this issue, with an estimated 234,580 new lung cancer cases and about 125,070 deaths anticipated in the U.S. Of these, nearly 80% to 85% are non-small cell lung cancer (NSCLC) cases, highlighting the urgent need for effective treatments.
MAIA Biotechnology, Inc. (AMEX: MAIA), a clinical-stage biopharmaceutical company focused on developing telomere-targeting immunotherapies for cancer treatment, has unveiled promising new clinical data showcasing the efficacy of its lead product candidate, THIO, in treating NSCLC. This data emerges from a phase 2 clinical trial evaluating THIO in combination with the immune checkpoint inhibitor (CPI) cemiplimab (Libtayo), targeting patients with advanced NSCLC who have not responded to at least two standard-of-care therapies.
In the context of NSCLC, where traditional treatments often fall short, THIO's potential as a first-in-class telomere-targeting agent raises hope. Its ability to disrupt cancer cell telomeres and stimulate immune responses marks a significant advancement in the fight against this devastating disease.
MAIAs Lead Candidate: THIO
THIO is a groundbreaking telomere-targeting agent, currently undergoing phase 2 clinical trials aimed at treating NSCLC with telomerase-positive cancer cells. Telomerase, present in over 85% of human cancers, plays a crucial role in the immortality and proliferation of cancer cells. THIO integrates into telomeres within these cells, disrupting their structure and function leading to rapid tumor cell death.
By inducing telomerase-dependent DNA modification and damage, THIO triggers selective cancer cell death. This process accumulates telomeric damage in cytosolic micronuclei, which then activates both innate (cGAS/STING) and adaptive (T-cell) immune responses. In in vivo cancer models, sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in significant and sustained tumor regression, fostering cancer-specific immune memory.
Key Findings From The Phase 2 THIO-101 Clinical Trial
The phase 2 THIO-101 trial primarily focuses on assessing the safety and tolerability of THIO both as an anticancer agent and as an immune system activator, alongside evaluating its clinical efficacy through overall response rate (ORR).
The trial results are noteworthy. The disease control rate (DCR) for THIO in combination with CPI was 85%, far exceeding the 25-35% DCR typically seen with chemotherapy in third-line treatments. Additionally, 65% of patients surpassed the 5.8-month overall survival (OS) threshold, and 85% exceeded the 2.5-month progression-free survival (PFS) threshold, demonstrating significant clinical benefits. The median survival follow-up time stood at 9.1 months for the cohort of 20 patients.
Optimal dose selection yielded even more impressive outcomes. Patients in third-line receiving 180mg of THIO exhibited a median PFS of 5.5 months, a 75% OS rate at six months and an ORR of 38%, compared to the standard 6-10% ORR for chemotherapy. Notably, 75% of these patients crossed the 5.8-month OS threshold and 88% surpassed the 2.5-month PFS threshold, with a median survival follow-up time of 9.1 months among the eight patients assessed.
Implications And Future Directions
Dr. Vlad Vitoc, chairman and CEO of MAIA, expressed enthusiasm about the trial outcomes, noting, "All exceptional measures of efficacy in our trial to date have exceeded our own expectations and outperformed standard-of-care treatments." He emphasized THIOs potential as a robust, safe and highly effective alternative for patients who have not benefited from chemotherapy and other treatments.
The THIO-101 trial, which completed enrollment ahead of schedule in February, reached its target of 41 patients for the 180 mg dose. This data, which indicates promising disease control and overall response rates, paves the way for further investigation and potential redefinition of cancer treatment protocols.
As THIO-101 data continues to demonstrate favorable disease control and response rates, with full efficacy data anticipated in the latter half of this year, MAIA Biotechnology stands poised to redefine cancer treatment. THIOs promise to transform the standard of care in oncology offers new hope to patients with advanced NSCLC, potentially establishing a new benchmark in cancer therapy.
Featured photo by CI Photos at Shutterstock.
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UBX to Launch Year-Long Global Tour, Expanding Web3 Horizons
In 2025, UBX will embark on a year-long global tour, covering key cities at the forefront of finance and technological innovation. As a leader in the cryptocurrency and digital asset space, the UBX Global Tour will officially kick off on January 9th in Ho Chi Minh City, marking the start of this highly anticipated annual event.
12 Cities in 12 Months: UBX Global Tour Unfolds
UBX’s global tour will follow a set schedule, with events held on the 18th of each month throughout 2025. After the inaugural stop in Ho Chi Minh City, the tour will visit cities such as Dubai (February 18), Macau (March 18), Bangkok (April 18), Paris (May 18), New Delhi (June 18), Vancouver (July 18), Abuja (August 18), South Korea (September 18), Singapore (October 18), Germany (November 18), and Tokyo (December 18). This series of events will cover twelve major cities, attracting thousands of participants at each stop. Industry leaders will gather to discuss the latest developments and innovations in Web3.
Engaging with Users: Building Stronger Connections
Each event will feature UBX’s latest updates and offer an opportunity for direct interaction with users, enabling the platform to gather valuable feedback and insights. UBX is committed to optimizing its products and services to meet the diverse needs of users worldwide. The global tour not only serves as an essential step in UBX’s global strategy but also as a platform for listening to and engaging with its user base.
Blending Online and Offline to Enhance User Experience
As a platform focused on cryptocurrency asset trading and innovation, UBX uses cutting-edge technologies like zero-knowledge proofs, multi-chain interoperability, and AI to build a secure and efficient system that protects user assets and privacy. By integrating innovative online products with its global offline events, UBX is providing users with secure, efficient, and intelligent trading solutions. This approach aims to foster continued innovation in the crypto ecosystem and enhance the overall user experience.
Promoting Industry Growth: UBX as a Compliant Leader
UBX is not only focused on technological advancements but also on driving the adoption of blockchain technology through its global tour. The tour will provide a vital platform for investors, industry professionals, and blockchain enthusiasts to explore blockchain applications across various sectors, accelerating the growth of Web3. Each event will offer valuable insights and strategic perspectives, contributing to the progress of the cryptocurrency industry. Furthermore, UBX remains committed to compliance, holding multiple financial licenses and solidifying its position as a key player in the global digital asset ecosystem.
In 2025, the UBX Global Tour will cover key Web3 markets, enhancing UBX’s global footprint while promoting the widespread adoption of blockchain technology. UBX invites investors, innovators, and blockchain pioneers to join this global movement, as together they help shape the future of the digital asset industry and usher in a new era of crypto wealth.
UBX Global Tour 2025: Join Us on This Historic Journey!
About UBX
UBX, headquartered on Wall Street, New York, is a global digital asset trading platform licensed in Canada, Australia, and the U.S. Focused on security, transparency, and compliance, UBX serves users across 36 countries with a daily trading volume of over $2 billion.
With cutting-edge technology and robust security, UBX offers spot trading, contracts, and asset management, striving to become a top-5 global digital asset exchange and a leader in secure digital finance.
Website：www.ubx.one
Telegram：https://t.me/UBX_Official
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Press Release
$LEIA token soars 2400% on its first day, showing the market is bullish on casual skill-based gaming in Web3
After raising a record $3M+ in its debut on Gems Launchpad, Leia hits the market today with a remarkable opening. Leia offers a diverse platform for casual gamers entering the crypto space via familiar and accessible mobile games
Limassol, Cyprus — Gems, a community-driven launchpad built around an exclusive investor network, celebrates the success of one of its leading launches: Leia, a Web3 gaming company offering a platform of skill-based mini-games. After securing $3M on Gems Launchpad, Leia meets the market today, itching $0.0195 in its peak on its first day. The initial token price on Gems Launchpad was $0.0001.
Leia Games offers an interactive way to play multiple small but casual games on one platform. Often called the “TikTok of gaming,” Leia features numerous skill-based games that use the same in-game currency. This creates an interoperable ecosystem that draws people in. Leia leverages Gems’s launchpad to expand its “Pikmi” gaming platform, boost its marketing efforts, and conduct alpha testing for its core titles.
Understanding and playing—let alone enjoying—Web3 games, which typically focus on the speculative NFT market and complex play-to-earn mechanics, can be challenging and time-consuming. While a miniscule niche market still exists for these Web3 games, the blockchain-based gaming sector has largely ignored the popularity of the casual mobile gaming sector, which makes up 61 percent of the overall gaming market, reaching a value of more than $130 billion in 2022.
Leia Gems is led by a team of industry veterans from Playtika.com with extensive experience designing successful and engaging mobile titles catered to casual gaming audiences. The team has designed an “Intelligent Matching System” to ensure fair and transparent contests featuring a skill-tracking algorithm that continuously monitors player performances to enforce balanced matches.
Gems Launchpad’s mission is to support projects with the most disruptive potential. Its latest project is NFA Club, a gamified, AI-powered trading app featuring curated insights from key opinion leaders (KOLs). NFA Club’s first private sale funding round on Gems Launchpad began on December 4, and will be raising funds over a series of 12 rounds.
$LEIA will be listed on Gems Trade, the new crypto exchange set to be released soon.
About Gems:
Gems is a distinguished crypto launchpad with the mission of un-earthing genuine “gems” in the Web3 landscape through rigorous due diligence. The platform aims to bring together a robust ecosystem for blockchain projects by focusing on launching innovative ventures, expanding communities, penetrating new markets, and leveraging its international network of investors, known as Leaders, to partake in the early stages of groundbreaking projects. Gems launchpad model is driven by active community participation, creating a synergistic environment that benefits both visionaries and the adoption of pioneering ideas. For more information, visit: https://gems.vip/
About Leia:
As the first company offering casual mobile games with a real monkey skill game twist in the Web3 space, Leia’s lineup includes casual puzzles, strategy games, and competitive casual eSports titles. By focusing on both casual fun and competitive mobile games which include in-game tournaments, Leia caters to a wide range of gaming preferences and skill levels. The $LEIA token serves as the primary currency within Leia’s ecosystem and is used to enter tournaments, purchase in-game items, and participate in community events. For more information, visit: https://www.leia.games/
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name: Alona Stein
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Assetsite is a leading cryptocurrency trading platform, renowned for its innovative approach to digital assets. Known for providing a user-friendly and robust environment for cryptocurrency traders, the company is now taking a bold step toward diversifying its investment portfolio. Assetsite has announced plans to invest in the chip industry, a strategic move that signals the company’s ambition to tap into the growing demand for semiconductor technologies.
United States, 9th Jan 2025 – With the global shift toward digital transformation and the increasing reliance on technology, the chip industry is poised for significant growth. Assetsite recognizes the vast potential of this sector and aims to leverage its resources to contribute to its development. The investment is expected to complement Assetsite’s existing focus on cryptocurrencies while exploring new opportunities in the tech-driven economy.
Why Invest in the Chip Industry?
Assetsite’s decision to invest in the chip industry comes at a time when the demand for semiconductors is soaring. Chips are the foundation of modern electronics, from smartphones and laptops to advanced artificial intelligence (AI) systems and autonomous vehicles. These critical components are essential to a wide array of industries, and their importance is only expected to grow as technology continues to evolve.
Here are some reasons why Assetsite believes this investment will be a key factor in the company’s growth strategy:
The Rise of Digital Technologies: As digital technologies such as AI, blockchain, and cloud computing gain prominence, the demand for semiconductors is rapidly increasing. Chips power everything from data centers to electronic devices, making them indispensable in today’s tech-driven world. Assetsite sees the chip industry as a high-growth sector with significant long-term potential.
Diversification of Investment Portfolio: Although Assetsite has carved out a strong position in the cryptocurrency market, the company recognizes the value of diversification. By branching out into the chip industry, Assetsite is ensuring its investment portfolio is balanced and resilient to market fluctuations. The chip industry offers a stable, technology-driven market that complements the volatility of the crypto world.
Tech Synergies with Cryptocurrency: As a company deeply entrenched in the cryptocurrency market, Assetsite understands the importance of cutting-edge technology in powering digital assets. Semiconductor technologies play a crucial role in supporting the infrastructure for cryptocurrency mining, blockchain systems, and other decentralized technologies. Assetsite plans to explore how its investments in chips can directly benefit the crypto ecosystem.
Long-Term Market Growth: The semiconductor market is expected to continue its expansion over the next few decades. With the rise of emerging technologies such as 5G, autonomous driving, and the Internet of Things (IoT), the demand for high-performance chips will only increase. Assetsite sees this as an opportunity to align itself with long-term market trends that show no signs of slowing down.
Innovation and Future-Proofing: Innovation is at the heart of Assetsite’s investment strategy. By investing in the chip industry, the company is positioning itself to take advantage of the technological breakthroughs that are driving the evolution of modern electronics. Whether it’s the development of more efficient chips or breakthroughs in AI and quantum computing, Assetsite is keen to be part of the next wave of innovation.
About Assetsite
Assetsite is a prominent cryptocurrency trading platform dedicated to providing a seamless and efficient environment for traders worldwide. The platform offers a wide range of digital assets, enabling users to trade with ease. Since its inception, Assetsite has maintained a strong focus on innovation and user experience, ensuring both new and experienced traders have the tools they need to succeed in the fast-paced world of cryptocurrency.
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The post Assetsite Expands Investment Horizons in Chip Industry appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.
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