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Citius Pharmaceuticals (NASDAQ: CTXR) Advances Oncology Asset, Paving Way For Spin Out Of Advanced T-cell Lymphoma Treatment

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By Meg Flippin, Benzinga

Chemotherapy and radiation are proven ways to treat cancer, but for the patients, they usually mean untold suffering. Finding effective alternatives, especially for people with rare cancers, can seem impossible. For rare cancers, there often isnt a lot of information to help develop treatments, enough animal or cell models to test, or tumor samples to research. As a result, rare cancers account for 25% of all cancer deaths in the U.S.

Immunotherapy To Kill Cancer Cells

One alternative treatment that seems to be getting attention is immunotherapy. Its a treatment that uses the patients immune system to seek and kill cancer cells. Immunotherapy treatments are designed to boost a patients immune system so the body can work harder to destroy cancer cells. It is proving effective with companies including Citius Pharmaceuticals Inc. (NASDAQ: CTXR) advancing oncology treatments through an innovative immuno-oncology approach.

Citius lead asset aims to leverage the body's own defense mechanisms to destroy malignant tumors. The therapy targets the interleukin-2 receptors found on malignant T-cells regulatory T-cells (Tregs), opening the potential for new therapeutic approaches to the treatment of cutaneous T-cell lymphoma (CTCL). This innovation could be transformative for individuals with rare cancers like CTCL, potentially enhancing their quality of life significantly. Additionally, Citius highlights compelling market opportunities that the company says are poised for growth. Broadly, the global cancer therapy market is forecast to grow at a CAGR of 9.12% from now until 2027, while the immuno-oncology market is projected to grow at a CAGR of 22.94%, hitting $396.07 billion by 2034.

LYMPHIR Poised to Make Inroads

The companys lead immunotherapy, LYMPHIR, is under review by the U.S. Food and Drug Administration (FDA) for the treatment of persistent or recurrent cutaneous T-cell lymphoma (CTCL), a rare form of non-Hodgkin lymphoma. In Japan, the formulation is approved and marketed for the treatment of CTCL and peripheral T-cell lymphoma (PTCL).

Just last month, the U.S. FDA accepted the resubmission of a Biologics License Application (BLA) for LYMPHIR for the treatment of patients with relapsed or refractory CTCL after at least one prior systemic therapy. According to the company, the FDA has assigned a PDUFA goal date of August 13, 2024, the company said.

"We believe there remains a critical unmet need for an additional viable treatment option for patients with relapsed or refractory CTCL as current therapies are non-curative, said Leonard Mazur, Chairman and CEO of Citius.

We are grateful for the FDA's vital support for rare disease drug development as we work to expand treatment options for patients with cutaneous T-cell lymphoma. We look forward to the FDA's decision and the potential benefit LYMPHIR may provide patients with relapsed or refractory CTCL, continued Mazur. Citius believes the market for LYMPHIR for CTCL will exceed $400 million and is particularly attractive because it is underserved by existing treatments.

The Proof Is In The Results

LYMPHIR is a recombinant engineered fusion protein that combines interleukin-2 and diphtheria toxin. The agent specifically binds to IL-2 receptors on the cell surface, causing diphtheria toxin fragments that have entered cells to inhibit protein synthesis. Notably, malignant T-cells and immunosuppressive regulatory T-cells share a common marker, the IL-2 receptor. Consequently, LYMPHIR targets both malignant T-cells and transiently eliminates Tregs, supporting the potential to unleash potent immune responses by the patients immune system against their tumors.

In recent preclinical studies, denileukin diftitox has demonstrated the ability to deplete murine Tregs in-vivo and human Tregs ex vivo. In addition, the combination of denileukin diftitox with anti-PD1 showed improved tumor response and very significant improvement in survival in the combination groups relative to either therapy alone in a syngeneic mouse solid tumor model.

Based on this data, two investigator-initiated trials are underway to evaluate the potential safety and efficacy of LYMPHIR in combination with Pembrolizumab (anti-PD1) in patients with recurrent or metastatic solid tumors and LYMPHIR given prior to lymphodepletion (LD) chemotherapy and CAR-T therapies for the treatment of relapsed/refractory B-cell lymphomas. The results of these preclinical trials will determine if the company will develop these treatments further.

The Path To Commercialization

In addition to inroads on the regularity front, the company is making strides to commercialize LYMPHIR. A spinout to form Citius Oncology is in the works. The company announced plans to form a standalone public oncology company a few months ago. In a recent press release, Citius mentioned the transaction will improve the companys access to the public equity markets and help facilitate the commercialization of LYMPHIR.

"We believe this transaction will allow us to unlock the value of LYMPHIR, and solidly position Citius Pharma to advance our diversified pipeline, said Mazur at the time.

This transaction will enable Citius Oncology, with access to the broader capital markets, to better support the successful commercialization of LYMPHIR, if approved, and explore additional potential targeted oncology therapies. Our majority ownership position and shared services agreement ensures that the Citius Pharma management team will remain fully engaged with the development and commercialization efforts at Citius Oncology.

Featured photo by the National Cancer Institute on Unsplash.

Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders.

This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.

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Press Release

Yantai City Hosts Gathering of the Wise, Guiding the Future High-Level Talent and Industry Matching Conference for Domestic and International Professionals

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China, 22nd Oct 2024 – Yantai City, Shandong Province, has been committed to opening up to the outside world and innovative development for many years, and has continued to promote high-quality economic and social development in the region. 

Recently, the city has organized the 2024 Overseas Chinese Scholars Serving the Motherland (PHASE 18) High-Level Talent and Industry Integration Conference, themed “Gathering of the Wise, Guiding the Future” was held in Yantai on September 26. Over 150 doctoral students and postdoctoral researchers from more than 30 countries and regions gathered for this talent integration event.

During the opening ceremony, Yantai City’s talent policies were prominently introduced, and the 2024 Yantai Matchmaking Symposium for at Home and Abroad High-level Talents and Industries Job Requirements List was released. A total of 45 key enterprises of“9+N”industries, 15 universities and research institutions in Yantai proposed a demand for 111 postdoctoral positions, 810 doctoral positions, and 200 overseas outstanding master’s positions. Positions in “high-precision and urgent shortage” fields offer an average annual salary of over 300,000 RMB, and the highest annual salary of some positions can be up to 1 million RMB. This event extended a heartfelt invitation to young talents at home and abroad aspiring to innovate and start businesses in Yantai. 8 doctoral talents signed agreements with the postdoctoral research stations and research workstations in Yantai. Additionally, 8 high-tech application development and industrialization projects in fields such as autonomous driving, precision medicine, and green circular new materials signed cooperation research agreements and talent incubation agreements on-site with related enterprises and industrial parks in Yantai.

The talent integration conference included four concurrent specialized activities. In the promotion activity, 6 key enterprises and universities, including Taihe New Materials Group Co., Ltd., detailed their development and talent recruitment policies. In the project roadshow activity, a total of 26 overseas talent projects, including the “AI-Based Intelligent Millimeter-Wave Radar Sensing System” were presented in a live roadshow, followed by matchmaking and negotiations with representatives from investment promotion and venture capital institutions. More than half of the entrepreneurial projects are expected to be incubated in Yantai. In the recruitment exchange activity, more than 60 companies set up recruitment booths to accurately connect with overseas students who are seeking jobs. In the discussion activity, 11 overseas student organizations representatives engaged in in-depth discussions with local departments about overseas talent recruitment cooperation and project recommendations. After the concurrent specialized activities, more than 50 overseas students participated in an experiential activity in Yantai, visiting local innovation parks, leading enterprises, and cultural landmarks to gain a comprehensive understanding of Yantai’s cityscape and innovation environment, fostering enthusiasm for working and starting businesses in Yantai.

This event was not only a grand gathering for overseas high-level talents and local industries but also an important manifestation of Yantai’s commitment to openness and innovative development. Yantai City will leverage this event to continuously optimize the talent development environment, provide higher quality services and support, and attract more outstanding talents to develop in Yantai. With the deep integration of talent and industry, a more vigorous innovative vitality is expected to be unleashed, injecting strong new momentum into the high-quality economic and social development of Yantai.

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The post Yantai City Hosts Gathering of the Wise, Guiding the Future High-Level Talent and Industry Matching Conference for Domestic and International Professionals appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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Press Release

Strickland Capital Group Launches Comprehensive Education Planning Services

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Mintao-ku, Tokyo, Japan, 21st Oct 2024 – Strickland Capital Group is excited to introduce its newly developed education planning services, created to provide families, parents, and students with the tools and guidance necessary to prepare for the increasingly complex educational landscape. As education costs continue to rise, effective planning is more important than ever, and Strickland Capital Group is committed to helping individuals navigate these challenges with ease.

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Recognizing the value of education as a transformative experience, Strickland Capital Group has designed a suite of services tailored to meet the diverse needs of families. Whether preparing for college, trade school, or postgraduate programs, these new services are intended to help clients manage the demands of educational preparation, both for children and adults returning to academia.

“We understand that planning for education can be overwhelming, and it’s not just about covering costs but also about making sure that the overall strategy aligns with a family’s broader objectives. Our goal is to empower families to feel confident in their decisions, knowing that their educational goals are supported by a clear and effective plan,” said a representative from Strickland Capital Group.

A Personalized Approach to Education Planning

What sets Strickland Capital Group’s education planning services apart is their personalized and comprehensive approach. The planning process starts with an in-depth consultation, during which the firm’s expert advisors work closely with clients to assess their unique needs, goals, and timelines. This approach allows Strickland Capital Group to develop tailored strategies, ensuring that each education plan is customized for individual situations.

The planning process encompasses a broad range of considerations, including:

Identifying short-term and long-term academic goals

Understanding the cost structure of different educational institutions

Preparing for ancillary costs such as books, supplies, and living expenses

Exploring potential opportunities, scholarships, and other resources that can contribute to the overall plan

Whether it’s helping parents plan for their children’s college years or assisting professionals who wish to return to school for further qualifications, Strickland Capital Group provides ongoing support and insights throughout the entire process.

Empowering Clients for the Future

Strickland Capital Group believes that proper education planning can unlock future potential. The firm is dedicated to helping clients make informed choices about where and how to invest in education, all while making sure their overall objectives are met. This ensures that students are not just ready for their next academic step but also well-positioned to achieve long-term success.

In addition to providing advice and strategies for managing education costs, Strickland Capital Group’s services include evaluating various educational paths, helping clients weigh the pros and cons of different schools, programs, and degree options. These insights enable families and individuals to make decisions that align with their career aspirations, personal growth, and life objectives.

“We believe that education is one of the most important foundations for success,” added the spokesperson from Strickland Capital Group. “By working with our team, clients can feel secure in knowing that they are taking the right steps to prepare for the future, no matter what stage of the education process they’re in.”

Dedicated to Long-Term Client Success

Strickland Capital Group has built its reputation on a commitment to helping families achieve their dreams through careful planning and thoughtful strategies. The firm’s education planning services are the latest addition to a wide range of offerings designed to support clients through major life events. From the earliest stages of childhood education to advanced degrees later in life, Strickland Capital Group Tokyo Japan is dedicated to helping clients navigate the complexities of education.

By taking a holistic approach, Strickland Capital Group ensures that all aspects of a client’s situation are considered. Whether a family is looking to plan for their child’s first year of school or an individual is returning to higher education later in life, Strickland Capital Group’s services provide the expertise and support needed to make those aspirations a reality.

About Strickland Capital Group

Strickland Capital Group is a leading provider of personalized planning services, offering clients the tools and strategies needed to achieve their goals. With a client-first philosophy, the firm focuses on helping families and individuals prepare for key life events, including education, retirement, and more. The team at Strickland Capital Group prides itself on delivering clear, actionable insights that empower clients to plan with confidence. For more information, visit www.stricklandcapitalgroup.com.

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Organization: Strickland Capital Group

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The post Strickland Capital Group Launches Comprehensive Education Planning Services appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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Video Content Becomes a Must-Have for SMEs in 2025: Driving Engagement and Growth

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In 2025, video content is no longer just a trend—it’s a necessity for small and medium enterprises (SMEs) aiming to stand out in the digital space. With video expected to account for 82% of all online traffic by the end of the year, businesses that invest in video marketing are seeing higher engagement, greater visibility, and stronger customer connections than ever before.

As digital marketing continues to evolve, SMEs are increasingly relying on video content to enhance their brand presence, drive conversions, and foster customer loyalty. Platforms like TikTok, Instagram Reels, and YouTube dominate the marketing landscape, making video a critical element in any business’s strategy. SMEs that fail to embrace this shift risk being left behind in an ever-competitive market.

Why SMEs Should Prioritise Video in 2025

Consumers overwhelmingly prefer video content when learning about new products or services. Whether it’s product demos, explainer videos, or customer testimonials, video helps SMEs communicate their value quickly and effectively. Social media platforms favour video in their algorithms, allowing businesses to reach wider audiences organically.

Not only does video increase visibility, but it also boosts conversion rates. According to industry research, adding a video to a landing page can increase conversions by up to 80%. For SMEs, this can be a game-changer, transforming casual viewers into paying customers.

Types of Video Content That Work for SMEs

There are several types of video content SMEs can leverage to connect with their audience:

  • Short-form videos: Platforms like Instagram Reels, TikTok, and YouTube Shorts offer quick, engaging content that appeals to younger consumers.
  • Live streaming: Live video for product launches, Q&A sessions, or behind-the-scenes content creates real-time engagement.
  • Educational videos: SMEs can build trust by offering how-to guides, tutorials, or product demonstrations.
  • User-generated content: Encouraging customers to create and share videos builds community and adds authenticity to a brand’s marketing efforts.

Cost-Effective Video Creation Tools for SMEs

The good news for small businesses is that creating high-quality video content doesn’t have to be expensive. Free or affordable tools like Canva, InShot, and Lumen5 enable SMEs to produce professional-looking videos that resonate with their audience. These tools allow businesses to edit, enhance, and optimise videos without requiring a large budget.

For SMEs looking to expand their reach locally, platforms like BeeLocal.UK offer a unique opportunity. As a free business advertising directory, BeeLocal.UK supports small businesses by offering a space to showcase their video content and reach local customers without the need for expensive marketing campaigns.

Leveraging Video for Advertising and Customer Engagement

Incorporating video into advertising campaigns, both organic and paid, is essential for businesses looking to grow in 2025. Video ads have proven to generate higher click-through rates and engagement, giving SMEs the chance to stand out in crowded social media feeds. BeeLocal.UK offers an ideal platform for businesses to advertise their products and services for free, including the integration of video content to captivate audiences.

“SMEs can also benefit from user-generated content, such as customer testimonials,” says [Your Name], [Your Position] at BeeLocal.UK. “Featuring real customer experiences through video adds credibility and trust, which can be a powerful way to drive new business.”

Video in E-commerce: The Future of Online Shopping

Video is also transforming the e-commerce experience, with shoppable videos allowing consumers to purchase products directly from video content. SMEs that embrace this trend can provide a seamless shopping experience, turning video views into immediate sales. From product demos to unboxing experiences, video helps bridge the gap between digital engagement and in-store shopping.

Businesses can further boost their online presence by incorporating video content into their listings on platforms like BeeLocal.UK, enhancing both visibility and customer trust.

Looking Ahead: The Future of Video in 2025

As technology evolves, new video trends will continue to emerge. In 2025, SMEs can expect to see an increase in the demand for interactive video formats, such as 360-degree videos, augmented reality (AR), and virtual reality (VR) content. These innovative formats allow businesses to offer immersive experiences, helping them stand out in a competitive marketplace.

Interactive videos, where viewers can make choices or influence the outcome, are also expected to rise in popularity. This offers SMEs a unique way to personalise customer interactions and deepen engagement.

Conclusion: Why SMEs Can’t Ignore Video in 2025

In 2025, video is an essential tool for SMEs to create connections, boost engagement, and drive sales. It’s not just about marketing—video helps businesses tell their stories, showcase their products, and build stronger relationships with customers.

For SMEs looking to take their video marketing to the next level, platforms like BeeLocal.UK provide free advertising opportunities to showcase video content to local consumers. Video is more than a trend—it’s a necessity, and with the right tools and strategies, SMEs can leverage it to thrive in the digital marketplace.

3. Contact details

1.  Company name: The Bee Seen Company

2.  Website link: https://beelocal.uk/

3.  Contact e m ail: hello@beelocal.uk

4.  Country: United Kingdom

5.  City: Alloa

6.  Contact person name: Lewis Cowan

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