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China Medical System: NDA for Additional Rheumatoid Arthritis Indication of Methotrexate Injection Approved in China

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SHENZHEN, CHINA – China Medical System Holdings Limited (the “Company”, together with its subsidiaries, the “Group” or “CMS”) is pleased to announce that on 30 July 2024, the New Drug Application (NDA) for an additional indication of Methotrexate Injection (the “Product”) has been approved by the National Medical Products Administration of China (NMPA). The Product is a small-volume methotrexate injection with various strengths for the treatment of active rheumatoid arthritis (RA) in adult patients. The Group was granted a certificate of drug registration on 5 August 2024.

 

Methotrexate is recognized internationally as the first choice first-line and anchor drug for RA. The Product is the first methotrexate prefilled injection to treat RA by subcutaneous administration in China, providing a safer, more effective, more convenient and more accurate administration scheme for RA adult patients.

 

According to the communication with NMPA, the bridge clinical trial of the Product in China (the “Study”) aims to compare the changes of DAS28-ESR score of patients with RA treated by methotrexate injection and methotrexate tablets compared with the baseline at week 12, and to judge whether the non-inferiority is established. The Study reached the preset primary endpoint, and the experimental group (given the Products) was not inferior to the control group (given methotrexate tablets). In addition, the results of secondary efficacy indicators suggest that the product has a tendency to have better efficacy than methotrexate tablets. The results also show that some of the curative effects that can be observed in the early stage of the Product are more obvious than those of methotrexate tablets, suggesting that the curative effect of the Product appears earlier. The Product has acceptable safety and tolerability, and is basically consistent with the safety characteristics observed in previous studies. No new safety risks have been found, and it has certain advantages over methotrexate tablets in terms of gastrointestinal adverse reaction[1].

 

In March 2023, the Product was approved for marketing in China for the treatment of severe recalcitrant disabling psoriasis, which is not adequately responsive to other forms of therapy such as phototherapy, PUVA, and retinoids. The Product was also announced as a Reference Listed Drug by NMPA. This indication has already entered into large-scale clinical application. After the approval of the additional RA indication, it can be directly applied to clinical application, which can improve the bioavailability and convenience of clinical treatment for RA patients, reduce gastrointestinal side effects. At the same time, it also reduces the burden of treatment on doctors and patients, so as to satisfy the demand for the basic gold standard drug for RA patients.

 

The Product has been approved by 21 European national competent authorities including Switzerland and United Kingdom. At present, the Product has been approved for marketing in 47 countries and regions around the world, including the European Union, Australia, China, etc.

 

The Group obtained a long-term effective and exclusive license for the Product from medac Gesellschaft für klinische Spezialpräparate m.b.H on 21 September 2020.

 

The rich innovation pipeline stands as a key driver for CMS’s long-term development. As of now, the Group’s newly approved innovative portfolio has been expanded into five products (including six indications), continuously injecting new momentum into sustained and healthy growth of the Group’s operation performance. The approval for the additional RA indication of the Product is a reaffirmation of CMS’s innovation strategy, and also a continuation and deepening of its strategic declaration of “New CMS, New Rise”, marking another milestone on its path of innovation.

 

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

 

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

 

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries. While strengthening the competitiveness of the cardio-cerebrovascular/gastroenterology business, CMS independently operates its dermatology and medical aesthetics business, and ophthalmology business, aiming to gain leading positions in specialty therapeutic fields, whilst enhancing the scale and efficiency. At the same time, CMS has expanded its business territory to the Southeast Asian market, striving to become a “bridgehead” for global pharmaceutical companies to enter the Southeast Asian market, further escorting the sustainable and healthy development of the Group.

 

Reference:

  1. The results of the bridge clinical trial in China was published and can be found at: https://web.cms.net.cn/en/2023/12/china-medical-systems-innovative-drug-progress-nda-for-additional-ra-indication-of-methotrexate-injection%ef%bc%88pre-filled-syringe%ef%bc%89accepted-in-china/

 

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

 

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

 

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

Source: China Medical System Holdings Ltd.

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ACTION Termite and Pest Control Expands Commercial Services Through Partnership with EcoServ Pest Elimination

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ACTION Termite & Pest Control increases its Phoenix MSA presence through Strategic Partnership with Phoenix-based, EcoServ Pest Elimination

Phoenix, AZ. – ACTION Termite and Pest Control (“ACTION”), a leading provider of pest control solutions in Arizona, is excited to announce its fifth strategic partnership with EcoServ Pest Elimination (“EcoServ”). EcoServ is a highly recognized commercial pest control company based in Phoenix, Arizona. This strategic collaboration marks a significant expansion into the commercial pest control sector and solidifies ACTION’s commitment to servicing commercial customers following its recent partnership with CimeX Control and the Phoenix Suns. ACTION is dedicated to becoming the premier provider of pest control services to residential and commercial customers across Phoenix and the surrounding areas.

“We are thrilled to welcome EcoServ Pest Control to the ACTION team! With decades of commercial pest control expertise, EcoServ will be instrumental in helping us scale our commercial services throughout the Southwest region,” said Brent Agee, CEO of ACTION Termite and Pest Control, “Steve Fisk, founder and former owner of EcoServ, will continue his leadership as Vice President of Commercial Services, ensuring the continued growth of our commercial division. EcoServ’s impressive portfolio, which includes large commercial accounts from resorts, food chains, malls, colleges, and more, aligns perfectly with our vision for expansion. We are excited for the future as we combine forces to deliver even greater service to our clients.”

ACTION’s fifth partnership will be seamlessly transitioned, with EcoServ’s operations and client relationships fully absorbed into the ACTION brand, ensuring a unified approach to service and customer experience. ACTION commends Steve Fisk, owner of EcoServ, and the rest of his team for their commitment to quality services for their customers and look forward to continuing the

high standards of service. ACTION looks forward to working with Steve in his new role where he will continue to develop and build commercial relationships for the brand.

“Over the past eight years, witnessing the EcoServ journey has been an incredible experience, and joining forces with ACTION is the perfect next step for our growth. I am thrilled to continue my role as VP of Commercial, inspired by ACTION’s leadership team, who are deeply committed to delivering exceptional service to our customers and fostering a dynamic, positive culture in their daily operations,” commented EcoServ Pest Elimination’s owner, Steve Fisk, “With access to more resources, cutting-edge technology, and the strongest team in the valley, I am excited to be part of expanding our company’s presence throughout Arizona and into neighboring states. EcoServ has always been known for its personalized, tailor-made service for our valued customers. Through this merger, we promise our customers an even higher level of service and care – Get ready for an exciting new chapter!”

This partnership underscore’s ACTION’s enthusiasm in delivering the highest level of service to all customers across Phoenix and consistently expanding on capabilities and offerings. By combining ACTION and EcoServ’s strengths, ACTION will be able to offer a comprehensive range of pest control services tailored to commercial properties, while continuing to deliver outstanding residential pest management services. The alignment of the two brands together ensures both company’s standards and values will be upheld under the new partnership.

To learn more about ACTION’s differentiated partnership approach and how you can be part of its winning team, connect with Chief Development Officer, Brian Marks at brianmarks@actiontermitecontrol.com.

About ACTION Termite and Pest Control

Founded in 1969, ACTION Termite and Pest Control is a leading provider of pest management services, offering comprehensive solutions to residential and commercial clients. With a focus on delivering customer satisfaction, ACTION Termite and Pest Control has become a trusted name in the pest control industry. Headquartered in Phoenix, Arizona, ACTION is actively seeking strategic partners who are excited for their next stage of growth. To learn more about ACTION Termite and Pest Control, please visit https://www.actiontermitecontrol.com. ACTION Termite & Pest Control 1101 W Melinda Ln STE B, Phoenix, AZ 85027 Phone: 602-899-2222

About EcoServ Pest Elimination

Founded in 2015 and based out of Phoenix, Arizona, EcoServ Pest Elimination is a pest control business focused on serving commercial customers throughout the Phoenix MSA. Owned by Steve Fisk and Michael Borden, the Company is a known provider of pest and termite control, rodent proofing, and bird management to commercial customers. To learn more about EcoServ Pest Elimination, please visit https://www.ecoservpest.com.

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Giloba by Mega We Care: A Natural Supplement for Cognitive Health

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Giloba is a popular herbal supplement from Mega We Care, known for its potential benefits in supporting cognitive function and overall brain health. Derived from the Ginkgo biloba plant, one of the oldest living tree species, Giloba is primarily used to enhance memory, improve concentration, and support mental clarity. With a long history in traditional medicine, Ginkgo biloba has gained popularity in modern health supplements due to its natural properties that may promote brain health and reduce the effects of aging on the mind.

In this article, we’ll explore what Giloba is, its key benefits, how it works, and why it has become a trusted choice for those looking to support their cognitive function. We’ll also discuss other related supplements such as Nat C, Eugica Herbal Infusion, Naprofazt, Enat Cream, Zirin, Ferrovit, Zeman SX, Calcivita and Enat, to provide a comprehensive look at health and wellness options.

What Is Giloba?

Giloba is a Ginkgo biloba-based supplement produced by Mega We Care, a reputable health and wellness company that specializes in natural and pharmaceutical products. The main active ingredient in Giloba is an extract of Ginkgo biloba leaves, which are rich in powerful compounds called flavonoids and terpenoids. These compounds are believed to possess antioxidant and anti-inflammatory properties, making Ginkgo biloba a widely used natural remedy for a variety of health concerns, particularly those related to the brain and cognitive function.

Key Benefits of Giloba

The primary appeal of Giloba lies in its potential to support mental and cognitive health. Here are some of the top benefits associated with the use of Giloba:

Improves Memory and Focus

One of the most well-known benefits of Ginkgo biloba is its ability to enhance memory, particularly in older adults. Giloba may help improve both short-term and long-term memory retention, making it a popular supplement for those seeking to boost mental clarity and focus. It may also be useful for students and professionals who need sustained concentration during study or work.

Boosts Circulation and Brain Health

Ginkgo biloba has been shown to improve blood circulation, particularly to the brain. By enhancing blood flow, Giloba helps deliver oxygen and nutrients to brain cells, which may support overall cognitive function and protect against age-related cognitive decline.

Reduces Symptoms of Cognitive Decline

Studies suggest that Ginkgo biloba supplements like Giloba may help alleviate symptoms of cognitive decline, such as confusion, forgetfulness, and lack of focus. This makes it a potential natural option for individuals dealing with early stages of dementia or other memory-related disorders.

Supports Mental Well-Being

Giloba may also have a positive impact on mental well-being by reducing anxiety and promoting a sense of calm. The antioxidant properties of Ginkgo biloba may help lower

stress levels, making it a useful supplement for individuals dealing with mental fatigue or anxiety.

May Help with Tinnitus

Some studies suggest that Ginkgo biloba could help relieve symptoms of tinnitus (ringing in the ears), a condition often linked to poor blood circulation in the inner ear. By improving blood flow, Giloba may potentially offer relief from the discomfort associated with this condition.

How Does Giloba Work?

Giloba works by leveraging the potent natural compounds found in Ginkgo biloba leaves. These compounds, particularly flavonoids and terpenoids, act as antioxidants that help protect the brain and body from oxidative stress caused by free radicals. Oxidative stress is a major factor in the aging process and can contribute to cognitive decline, memory loss, and other neurological issues.

By enhancing blood circulation to the brain, Giloba helps ensure that the brain receives a steady supply of oxygen and essential nutrients. This improved blood flow is crucial for maintaining healthy cognitive function and reducing the risk of age-related mental decline.

Additionally, Giloba’s antioxidant properties may help reduce inflammation in the brain, further supporting mental clarity and reducing the risk of cognitive disorders.

Complementary Health Products

While Giloba offers significant benefits, it’s worth considering other supplements and products that can complement your health and wellness routine:

  • Nat C: A high-quality vitamin C supplement that supports immune function and overall health. It can work synergistically with Giloba to boost general well-being and enhance the body’s defense mechanisms.
  • Eugica Herbal Infusion: This herbal infusion provides a natural way to support respiratory health and overall wellness. It can be a great addition to a health regimen that includes cognitive support from Giloba.
  • Naprofazt: An anti-inflammatory supplement that can help manage inflammation in the body, potentially supporting overall health alongside Giloba.
  • Enat Cream: A topical product known for its benefits in skin health. While not directly related to cognitive function, maintaining overall health and wellness can complement the effects of Giloba.
  • Zirin: A supplement aimed at improving joint health and mobility. Keeping the body healthy and active can support cognitive function indirectly.
  • Ferrovit: An iron supplement that helps maintain healthy blood levels. Good circulation supports brain health, making Ferrovit a useful complementary supplement.
  • Zeman SX: A supplement that supports general health and well-being. It can be used alongside Giloba to maintain overall vitality.
  • Enat: Another supplement that may contribute to overall health. Combining it with Giloba can provide a comprehensive approach to well-being.

Is Giloba Safe to Use?

Giloba by Mega We Care is considered safe for most people when taken as directed. However, like any supplement, it’s important to use it responsibly and consult with a healthcare professional, especially if you have pre-existing health conditions or are taking other medications.

Some individuals may experience mild side effects such as headaches, dizziness, or gastrointestinal issues when using Ginkgo biloba supplements. Additionally, people with bleeding disorders or those taking blood-thinning medications should be cautious when using Giloba, as Ginkgo biloba can have mild blood-thinning effects.

Who Can Benefit from Giloba?

Giloba is ideal for a wide range of individuals, especially those who are looking to support their cognitive health, improve memory and focus, or manage symptoms of mental fatigue. The supplement may be particularly beneficial for:

  • Older adults experiencing age-related memory decline or mild cognitive impairment
  • Students and professionals seeking enhanced concentration and mental clarity
  • Individuals experiencing mental fatigue or stress-related cognitive issues
  • Those looking for natural support in managing mild symptoms of anxiety or tinnitus

How to Take Giloba

Giloba is available in capsule form, making it easy to incorporate into your daily routine. It’s important to follow the dosage instructions provided on the packaging or consult with a healthcare provider to determine the appropriate dosage for your specific needs.

Conclusion

Giloba by Mega We Care offers a natural and effective way to support cognitive health and improve mental clarity. With its Ginkgo biloba-based formula, Giloba helps enhance memory, focus, and overall brain function by improving blood circulation and protecting the brain from oxidative stress. While generally considered safe, it’s important to consult with a healthcare professional to ensure Giloba is right for you, especially if you have any underlying health concerns or are taking medications.

By incorporating Giloba into your daily wellness routine, you may experience improved mental sharpness, reduced mental fatigue, and better overall cognitive well-being.

Additionally, consider complementing your health regimen with other beneficial products like Nat C, Eugica Herbal Infusion, Naprofazt, Enat Cream, Zirin, Ferrovit, Zeman SX, and Enat to support a holistic approach to wellness.

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St. Paul’s PACE Hosts Annual Donation Event for National PACE Month

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In honor of National PACE Month, St. Paul’s PACE – Program of All-Inclusive Care for the Elderly – hosted its annual St. Paul’s Essential Needs Drive (SPEND) at the St. Paul’s Conference Center in Bankers Hill. The event aimed to raise awareness for the growing segment of low-income seniors struggling to afford items essential for daily living.

El Cajon, CA, United States, 21st Sep 2024 Each year, SPEND collects supplies for PACE participants in need, from toiletries and cleaning products to new clothing and non-perishable food items. Donations are distributed across St. Paul’s PACE locations in San Diego County, including Chula Vista, El Cajon, Downtown, and Encinitas.

 “We received well over 500 donation items this year, thanks to the generosity of our neighbors and industry partners,” said Jennifer Romero, Marketing Director for St. Paul’s. “It was especially moving to witness staff members and even residents from our local senior communities come out to support the cause.”

At St. Paul’s, SPEND is a key initiative of National PACE Month, which highlights how PACE helps seniors thrive independently in their communities. This year’s theme from the National PACE Association, “Simplify Your Life: At Your PACE,” emphasizes the advantages of PACE’s personalized care plans tailored to seniors’ unique needs.

To qualify for St. Paul’s PACE, seniors must be over 55, have a chronic medical condition, and be enrolled in Medi-Cal. With many PACE participants living below the poverty line in California, donations from events like SPEND can make a significant impact.

St. Paul’s PACE continues to accept donations of non-perishable food, toiletries, personal hygiene products, and clothing for SPEND. Those who wish to contribute can do so through their Amazon Wish List or by visiting StPaulSeniors.org/SPEND for more ways to give. 

St. Paul’s PACE supports seniors so they can continue to live independently at home by providing personalized medical services, social services, transportation, and home care. Seniors who are over 55 years years old with chronic medical conditions that make it difficult to live at home may qualify for services. For more information on St. Paul’s PACE, please visit StPaulsPACE.org or call 1(833) PACE NOW. Press contact:  Nicole Antonacci, St. Paul’s Senior Services Communications Specialist, 619-239-6900

Media Contact

Organization: St. Paul’s PACE

Contact Person: Nicole Antonacci

Website: https://www.stpaulspace.org

Email: Send Email

Contact Number: +16195517400

Address: 1306 Broadway

City: El Cajon

State: CA

Country: United States

Release Id: 21092417214

The post St. Paul’s PACE Hosts Annual Donation Event for National PACE Month appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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