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China Medical System: First Prescriptions for Innovative Drug Lumeblue® Issued in China

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3 months ago

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SHENZHEN, CHINA – On 6 December, China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that the first prescriptions for the innovative drug Lumeblue® (Methylthioninium Chloride Enteric-coated Sustained-release Tablets) (the “Product”) have been issued in China, which marks that the first oral methylthioninium chloride enteric-coated sustained-release tablets in China has officially entered clinical application. The Product is indicated for enhancing visualization of colorectal lesions in adult patients undergoing screening or surveillance colonoscopies.

 

Lumeblue® is an oral diagnostic drug that uses patented multi-matrix (MMXTM) technology to deliver active substances directly to the colon and release them locally in a controlled manner. As an enhancer dye, the Product increases the contrast between colorectal lesions and healthy mucosa. The results of the Phase III clinical trial in China show that the Product can significantly improve the detection rate of non-polypoid colorectal lesions (the primary endpoint of the study), leading to an improved detection rate of dangerous lesions such as non-polypoid adenomas (the secondary endpoint)[1]. In addition, the Product can be taken during the bowel preparation step, ensuring that colorectal staining is completed by the time colonoscopy is conducted. This not only enhances the detection rate of colorectal lesions but also potentially simplifies the colonoscopy procedure, making the examination more efficient and improving the screening benefits.

 

According to the diagnosis and treatment data of the Digestive Endoscopy Branch of the Chinese Medical Association, approximately a total of 28 million gastroenteroscopies were completed nationwide in 2012, including 5.83 million colonoscopies. In 2019, approximately 38.73 million gastroenteroscopies were completed nationwide, an increase of 34.62% compared with 2012[2]. The Expert consensus on the early diagnosis and treatment of colorectal cancer in China (2023 edition) recommends colorectal cancer screening for individuals aged 40 to 74[3]. Based on the China Statistical Yearbook (2023), the total population of this age group in China is 643.36 million[4]. With the popularization of early colorectal cancer screening in China, the number of colonoscopies performed is expected to have significant growth potential in the future. Early diagnosis and removal of lesions are crucial for prevention. Lumeblue® provides an innovative solution for colorectal disease screening and management in response to this growing demand.

 

The Product has been approved by the European Medicines Agency (EMA) to be commercialized in the European Union under the trade name Lumeblue® in August 2020. The Group obtained an exclusive license for the Product from Cosmo Technologies Ltd., a fully-owned subsidiary of Cosmo Pharmaceuticals NV, on 3 December 2020. Following its approval in China in June 2024, CMS worked collaboratively across its business segments to ensure the rapid importation of the first batch of products. The Group has also actively leveraged its existing gastroenterology portfolio and resources to orderly advance the commercialization and academic promotion of Lumeblue®, facilitating its successful prescriptions launch in China.

 

With this milestone, CMS’s five innovative drugs have been successfully approved in China and fully entered clinical application. This achievement demonstrates the Group’s ongoing capability of innovation transformation, while reflecting CMS’s commitment to focusing on medical value and fulfilling its corporate social responsibility. Looking ahead, CMS will continue to be patients-centered, efficiently advancing the clinical development and commercialization of innovative products. The Group is dedicated to improving the accessibility and affordability of innovative drugs, benefiting a broader patient population.

 

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

 

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

 

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries. While strengthening the competitiveness of the cardio-cerebrovascular/gastroenterology business, CMS independently operates its dermatology and medical aesthetics business, and ophthalmology business, aiming to gain leading positions in specialty therapeutic fields, whilst enhancing the scale and efficiency. At the same time, CMS has expanded its business territory to the Southeast Asian market, striving to become a “bridgehead” for global pharmaceutical companies to enter the Southeast Asian market, further escorting the sustainable and healthy development of the Group.

 

References:

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

 

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

 

 

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

Source: China Medical System Holdings Ltd.

 

  1. The results of the Product’s Phase III clinical trial in China were published and are available at: https://web.cms.net.cn/en/2022/12/positive-results-for-china-phase-iii-c…
  2. Data from the Digestive Endoscopy Branch of the Chinese Medical Association
  3. Early Diagnosis and Treatment Group of the Chinese Society of Oncology. “Expert Consensus on Early Diagnosis and Treatment of Colorectal Cancer in China (2023 Edition).” Chinese Medical Journal, 2023, 103(48): 3896-3908. DOI: 10.3760/cma.j.cn112137-20230804-00164
  4. National Bureau of Statistics. (2023). China Statistical Yearbook 2023. Retrieved from https://www.stats.gov.cn/sj/ndsj/2023/indexch.htm

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Press Release

Maratopia Commits to EEAT for AI in 2025

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2 hours ago

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March 15, 2025

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Huddersfield, United Kingdom, 15th Mar 2025– The digital landscape is evolving, and with the rise of AI generated content in 2025, E-E-A-T (Experience, Expertise, Authoritativeness, and Trustworthiness) has become more important than ever. The continued increase of misinformation has also led to stricter search engine guidelines. In order to rank on search engines such as Google, businesses and content creators must prioritise credibility and E-E-A-T.

 

Under the lead of their CEO Steve Harvey-Franklin, Yorkshire based Search Marketing Agency Maratopia have committed to creating valuable content for their clients that keeps up with Google’s continued push for Experience, Expertise, Authoritativeness, and Trustworthiness. 

“With AI, everything seems to have changed, but really it’s all still the same. AI is a valuable tool, but shouldn’t be used to write content for SEO. Securing the AI Overview position on Google like the featured snippet spot, requires good original content. Put yourself in Google’s shoes, for Google to use content for its own AI result, it needs to demonstrate that it is authoritative, written with Expertise and Experience and that it is from a Trustworthy source and engenders Trust itself. So what was good for content in 2023/2024 is even more relevant for 2025 and beyond, without new content, new ideas, new opinions, new ways of saying things AI results die.”

Steve Harvey-Franklin

Google’s Latest Updates

Relying on AI generated content, particularly when it comes to YMOYL (your money or your life) advice can have a detrimental impact on business, with Statista finding less than 25% of consumers trust AI when it comes to medical or legal advice.

This has led to a series of updates from Google to weed out poor quality, AI generated content. The updates that Google has made to its search engine show that they are continuing to prioritise authoritative content that is well-researched and driven by experience when choosing which sites to rank for any given keyword.

What Does E-E-A-T Mean in 2025

Experience: As real world insights now hold more weight in Google rankings, it’s important that a brand’s content reflects first hand experience.

Expertise: To give a brand’s content more value, contributors should either have extensive industry knowledge or a recognised qualification. 

Authority: When the published content cites reputable sources and secures backlinks from quality sites, it can help to improve its credibility

Trust: By maintaining a secure website and being transparent, contributors can help to improve the rankings of a page and build lasting trust with their readers. 

For more information on Maratopia’s commitment to Google’s E-E-A-T requirements, then visit Maratopia at https://www.maratopia.co.uk/ today.

About Maratopia

Maratopia is a Yorkshire based Search Marketing Agency with more than 20 years of experience in SEO, PPC, and Web Development, and part of The Think Again Group. Founded in 2003 by Steve Harvey-Franklin, the agency is committed to driving their clients to the top of the search engine rankings. 

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Press Release

Get Bubu Dudu Celebrates 100K orders Delivered Worldwide

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2 hours ago

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March 15, 2025

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Get Bubu Dudu, the leading online store for adorable Bubu Dudu plushies and merchandise, proudly announces a major milestone—100,000 orders delivered worldwide! This achievement marks a significant moment in the brand’s journey, reflecting its growing popularity and the love fans have for the iconic Bubu Dudu characters.

A Milestone Worth Celebrating

Since its launch, Get Bubu Dudu has been dedicated to bringing joy to fans of all ages with high-quality, officially licensed Bubu Dudu plushies, accessories, and collectibles. Reaching 100K orders is a testament to the brand’s commitment to quality, customer satisfaction, and the growing global demand for these lovable characters.

“We are beyond thrilled to celebrate this incredible milestone,” said a Amanda Jarwis from Get Bubu Dudu. “Our fans have shown immense love and support, and we are grateful for every single order. This achievement motivates us to continue delivering the best Bubu Dudu products worldwide.”

The success of Get Bubu Dudu is driven by its dedication to providing authentic and high-quality Bubu Dudu merchandise, fast and reliable worldwide shipping, exceptional customer service and exclusive designs and limited-edition collections. With a growing community of fans, Bubu Dudu plushies have become a must-have for collectors and enthusiasts alike.

Special Promotions to Thank Customers

To celebrate this milestone, Get Bubu Dudu is offering exclusive discounts, giveaways, and limited-time promotions on its official website. Fans can enjoy special deals on their favorite Bubu Dudu plushies, keychains, and accessories as a token of appreciation for their continued support.

What’s Next for Get Bubu Dudu

As Get Bubu Dudu continues to expand, the brand is excited to introduce new Bubu Dudu plush designs, exclusive collaborations and more worldwide shipping options for faster delivery. With a strong community of fans and collectors, Get Bubu Dudu is set to reach even greater milestones in the future.

Join the Celebration!

Fans can join the celebration by visiting Get Bubu Dudu’s official website and taking advantage of special promotions. Follow the brand on social media for the latest updates, giveaways, and new product launches.

About Get Bubu Dudu

Get Bubu Dudu is a leading online store specializing in Bubu Dudu plushies, accessories, and collectibles. With a commitment to quality and customer satisfaction, the brand has successfully delivered 100,000+ orders worldwide, bringing joy to fans across the globe.

For more information, visit Get Bubu Dudu and explore the latest adorable Bubu Dudu merchandise collection!

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Press Release

Fox Landscaping Introduces Premium Outdoor Living Solutions to Elevate Outdoor Spaces in Novelty, OH

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4 hours ago

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March 14, 2025

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Fox Landscaping, a trusted name in high-quality landscaping and hardscaping, is excited to introduce premium Outdoor Living Solutions for homeowners in Novelty, OH, and surrounding areas. Specializing in custom outdoor kitchens, luxury fire pits, stylish pergolas, and high-end paver patios, Fox Landscaping is setting a new standard for outdoor enjoyment. As more homeowners look to extend their living space outdoors, this innovative expansion offers beautifully designed, functional outdoor environments tailored to modern lifestyles. Visit foxlandscapingohio.com to learn more.

Novelty, Ohio, United States, 14th Mar 2025 – Fox Landscaping, a locally owned and operated landscaping company, is thrilled to announce its latest innovation: custom-designed Outdoor Living Solutions, tailored to enhance backyards, patios, and outdoor spaces with the perfect blend of style, function, and durability.

As more homeowners seek to transform their outdoor areas into stylish, functional extensions of their homes, Fox Landscaping is leading the way with premium installations, including fully-equipped outdoor kitchens, luxury fire features, paver patios, and elegant pergolas. This new service expansion is designed to bring people together, create comfortable entertainment spaces, and increase property value—all while embracing high-quality craftsmanship and expert design.

Transforming Outdoor Spaces with Functional Luxury

This expansion marks a significant step forward in Fox Landscaping’s mission to bring cutting-edge, high-end outdoor living solutions to the community. These additions are not just about aesthetics—they’re about creating year-round gathering spaces where families and friends can cook, relax, and entertain in style.

“We’ve seen a growing demand for more than just traditional landscaping—homeowners want outdoor spaces that feel like an extension of their home,” said David Eippert, Owner of Fox Landscaping. “With our custom outdoor kitchens, fire pits, pergolas, and patios, we’re helping our clients create inviting spaces that are both functional and stunning.”

What’s New? Introducing Outdoor Living Like Never Before

Fox Landscaping’s latest services include:

Custom Outdoor Kitchens – Fully equipped with built-in grills, pizza ovens, refrigerators, and countertops, perfect for outdoor cooking and entertaining.

Luxury Fire Pits & Fireplaces – Beautifully crafted fire features designed for warmth, ambiance, and cozy gatherings.

Paver Patios & Walkways – Elegant, durable patios that enhance outdoor aesthetics and provide a perfect setting for entertaining.

Pergolas & Gazebos – Stylish, shaded structures that add character and comfort to any outdoor space.

Professional Drainage Solutions – Engineered to protect outdoor investments by preventing flooding and erosion.

Each project is custom-designed to suit individual preferences, property layouts, and lifestyle needs. From intimate backyard retreats to expansive entertainment spaces, Fox Landscaping is redefining outdoor living in Northeast Ohio.

Why Homeowners Are Excited About This Expansion

More Time Outdoors – With high-end features, homeowners can enjoy their outdoor spaces year-round.
Increased Property Value – These premium installations significantly boost curb appeal and home resale value.
Built to Last – Fox Landscaping uses only the best materials and expert craftsmanship for long-term durability.
Seamless Integration – Every design is tailored to complement the home’s architecture and existing landscape.

A Commitment to Excellence & Community Growth

As a proud part of the Novelty, OH community, Fox Landscaping is committed to providing exceptional services that enhance the way people experience their homes. By introducing premium outdoor living solutions, the company aims to offer residents new ways to entertain, relax, and create lasting memories in their own backyards.

“We believe an outdoor space should be more than just a backyard—it should be an experience,” said David Eippert. “We are excited to bring these new services to our community and help homeowners create truly remarkable outdoor environments.”

Upgrade Your Outdoor Living Space Today

For homeowners looking to elevate their outdoor spaces with custom designs, Fox Landscaping is now booking consultations for Spring 2025. To learn more about these premium outdoor solutions or to schedule a consultation, visit foxlandscapingohio.com or contact Fox Landscaping directly.

Media Contact

Organization: Fox Landscaping

Contact Person: David Eippert

Website: https://foxlandscapingohio.com

Email: Send Email

Contact Number: +12163375182

Address: 9315 Fairmount Road

City: Novelty

State: Ohio

Country: United States

Release Id: 14032525184

The post Fox Landscaping Introduces Premium Outdoor Living Solutions to Elevate Outdoor Spaces in Novelty, OH appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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