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China Medical System Completes Dosing of the First Subject in Phase III Bridging Trial of Ruxolitinib Cream in Atopic Dermatitis in China

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SHENZHEN, CHINA – On June 25, China Medical System Holdings Limited (the “Company”, together with its subsidiaries, the “Group” or “CMS”) announced the completion of dosing for the first subject in the phase III bridging trial of ruxolitinib cream (the “Product”) in atopic dermatitis (“AD”) in China. This is another substantial clinical development milestone for ruxolitinib cream in China, following the approval for Urgent Clinical Import by Hainan Medical Products Administration and approval for marketing in Macau for vitiligo.

This trial is a randomized, double-blind, placebo-controlled phase III clinical trial evaluating the efficacy and safety of ruxolitinib cream in the treatment of atopic dermatitis in Chinese patients. The trial aims to provide more medical evidence to support the Product’s marketing application in China. The trial, led by Professor Shi Yuling, Vice President of Shanghai Skin Disease Hospital, will be conducted in 20 sites nationwide aiming to enroll approximately 192 atopic dermatitis patients.

AD is a chronic, recurrent and inflammatory dermatologic disease, with the main clinical manifestations of dry skin, chronic eczema-like lesions and obvious itching or pruritus, which may seriously affect the quality of life of patients. It is estimated that there are approximately 26 million[1] AD patients in China, of whom about 23 million[2] are mild to moderate. Topical drugs are the most basic treatment for AD. Traditional topical medications such as topical corticosteroids (TCSs) and topical calcineurin inhibitors (TCIs) have long-term adverse reactions or limited efficacy[3] [4], therefore novel treatments are urgently needed, especially for those mild to moderate AD patients who do not need systemic treatment.

About ruxolitinib cream

Ruxolitinib cream (Opzelura®), a novel cream formulation of Incyte’s selective JAK1/JAK2 inhibitor ruxolitinib, is approved by the U.S. Food and Drug Administration (FDA) for the topical treatment of nonsegmental vitiligo in patients 12 years of age and older, and is the first and only treatment for repigmentation approved for use in the United States[5]. Opzelura is also approved in the U.S. for the topical short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis (AD) in non-immunocompromised patients 12 years of age and older whose disease is not adequately controlled with topical prescription therapies, or when those therapies are not advisable[6]. Use of Opzelura in combination with therapeutic biologics, other JAK inhibitors, or potent immunosuppressants, such as azathioprine or cyclosporine, is not recommended. In Europe, ruxolitinib cream (Opzelura) is approved for the treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age[7].

Ruxolitinib cream is not approved by the National Medical Products Administration of China (NMPA) for any indication in Mainland of China. However, on 12 August 2023, the Product was approved by Hainan Medical Products Administration for Urgent Clinical Import, and officially became available to applicable patients in the Hainan Boao Lecheng International Medical Tourism Pilot Zone (the “Pilot Zone”) on 18 August, for the topical treatment of non-segmental vitiligo in adults and adolescents aged 12 and above with facial involvement. Benefiting from the Early and Pilot Implementation Policy granted by the state to Hainan Free Trade Port and the Pilot Zone, patients with vitiligo in China can apply for the Product in Boao Super Hospital first and receive treatment from the expert team. The Group is cooperating with Boao Super Hospital to conduct the Real World Research (RWS) for the Product, which could support the registration and launching of the Product in Mainland of China.

Moreover, the Pharmaceutical Administration Bureau (ISAF) of Macau has approved the new drug application of ruxolitinib cream for the treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age on 11 April 2024, and it may bring a novel therapeutic option to patients with relevant indication in the area.

Incyte has worldwide rights for the development and commercialization of the Product, marketed in the United States and Europe as Opzelura®. CMS has an exclusive license to develop and commercialize the Product in Mainland China, Hong Kong Special Administrative Region, Macau Special Administrative Region, Taiwan Region and eleven Southeast Asian countries (the “Territory”) and a non-exclusive license to manufacture the Product in the Territory.

Opzelura and the Opzelura logo are registered trademarks of Incyte.

CMS continues to pay close attention to patients’ needs, and actively promotes the R&D and clinical application of innovative products to address unmet clinical needs, bringing more quality medical products to patients through differentiated innovation breakthroughs.

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries. While strengthening the competitiveness of the cardio-cerebrovascular/gastroenterology business, CMS independently operates its dermatology and medical aesthetics business, and ophthalmology business, aiming to gain leading positions in specialty therapeutic fields, whilst enhancing the scale and efficiency. At the same time, CMS has expanded its business territory to the Southeast Asian market, striving to become a “bridgehead” for global pharmaceutical companies to enter the Southeast Asian market, further escorting the sustainable and healthy development of the Group.

Reference:

1. M.R. Laughter, M.B.C. Maymone, S. Mashayekhi, B.W.M. Arents, C. Karimkhani, S.M. Langan, R.P. Dellavalle, C. Flohr, The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990–2017, British Journal of Dermatology, Volume 184, Issue 2, 1 February 2021, Pages 304–309, https://doi.org/10.1111/bjd.19580

2. Chiesa Fuxench ZC, Block JK, Boguniewicz M, Boyle J, Fonacier L, Gelfand JM, Grayson MH, Margolis DJ, Mitchell L, Silverberg JI, Schwartz L, Simpson EL, Ong PY. Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population. J Invest Dermatol. 2019 Mar;139(3):583-590. doi: 10.1016/j.jid.2018.08.028. Epub 2018 Oct 30. PMID: 30389491

3. “Research Report on the Living Conditions of Atopic Dermatitis Patients in China” August 2020

4. Yimi Survey “Atopic Dermatitis Diagnosis and Cognition Survey” October 2023

5. Drug approval information can be found on the FDA official website, as follows: https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-topical-t…

6. Drug approval information can be found on the Incyte official website, as follows: https://investor.incyte.com/news-releases/news-release-details/incyte-an…

7. Drug approval information can be found on the EMA official website, as follows: https://www.ema.europa.eu/en/medicines/human/EPAR/opzelura

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

 

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Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

Source: China Medical System Holdings Ltd.

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COZYINN Introduces the 2-in-1 Folding Walking Pad with Incline: The Ultimate Under Desk Treadmill for Home and Office Fitness

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USA, October 2024 – COZYINN, a trusted name in innovative fitness equipment, is excited to announce the release of its latest product, the COZYINN Walking Pad Under Desk Treadmill. This 2-in-1 folding treadmill is designed to seamlessly fit into modern lifestyles, combining productivity with fitness for those who want to stay active while working or at home.

The COZYINN Walking Pad offers a powerful and quiet motor, a compact and foldable design, and smart control features, making it the perfect solution for individuals looking to maintain a healthy routine without compromising their busy schedules. Whether for walking, jogging, or running, this treadmill is engineered for ultimate convenience and efficiency, allowing users to achieve their fitness goals without leaving the comfort of their home or office.

2-in-1 Folding Design for Versatile Fitness Options

The COZYINN Walking Pad can function as both a walking pad and a standard treadmill, providing versatility that fits different fitness preferences. When the handle is folded down, it acts as an under-desk treadmill, perfect for walking at speeds between 0.6 to 3.8 mph. This allows users to engage in light exercise while working at a stand-up desk, encouraging movement throughout the day.

When the handle is raised, the COZYINN Walking Pad transforms into a full treadmill, capable of speeds up to 7.6 mph, ideal for jogging or running. This 2-in-1 feature makes it a practical choice for those who want to walk during work hours and engage in more intense workouts during their leisure time.

Powerful and Quiet Performance

The COZYINN Walking Pad is powered by a 2.5HP quiet motor, supporting users weighing up to 320 pounds. The treadmill offers a speed range from 0.6 to 7.6 mph, providing flexibility for a wide range of workout intensities, from casual walking to faster-paced running. Despite its robust performance, the motor operates whisper-quiet, ensuring that users can exercise without disturbing their surroundings, whether in an office, apartment, or home.

“We’ve designed the COZYINN Walking Pad to cater to the needs of modern professionals and fitness enthusiasts who value both productivity and health,” said a COZYINN spokesperson. “With this treadmill, you can achieve your fitness goals while working, all without sacrificing comfort or space.”

Superior Comfort and Shock Absorption

The treadmill features a 16″ x 41″ anti-slip running belt, offering ample space for walking, jogging, and running. It is equipped with 5 layers of anti-slip material8 silicone shock absorbers, and 2 soft cushions to minimize joint impact. These features ensure a comfortable, low-impact workout that protects users’ knees and muscles while delivering a smooth and enjoyable running experience.

The diamond texture running belt enhances the treadmill’s durability, ensuring it maintains its anti-slip and wear-resistant properties even during high-frequency workouts. This makes it a long-lasting investment for users committed to staying active.

No Assembly and Space-Saving Design

One of the standout features of the COZYINN Walking Pad is its compact and foldable design. Requiring no assembly, the treadmill is ready to use straight out of the box. Its slim profile, measuring 47.1” D x 22.4” W x 4.9” H, and folding dimensions of 52.8” L x 22.4” W x 4.9” H, make it easy to store in tight spaces, such as under a desk, bed, or sofa.

At just 49 pounds, the walking pad is lightweight and equipped with built-in wheels, allowing users to effortlessly move it around and store it when not in use. This space-saving design makes the COZYINN Walking Pad ideal for homes, offices, or apartments where space is limited.

Smart Fitness with APP, Console and Remote Control

To enhance the user experience, the COZYINN Walking Pad is integrated with the KINOMAP, ZWIFT and WELLFIT apps, which provide personalized fitness data tracking and offer over 25 preset programs. These apps also include fitness training videos, customized workout plans, and dynamic data analysis, allowing users to enjoy a gym-quality experience at home. Additionally, there are no subscription fees, giving users free access to a wealth of fitness resources.

The treadmill can also be controlled through Console, APP or remote control, making it easy to adjust speed, monitor progress, and track key metrics such as time, speed, distance, and calories burned. This feature-rich design allows users to stay informed and make real-time adjustments to their workout.

Designed for Health-Conscious Professionals

With many professionals working from home or hybrid settings, the COZYINN Walking Pad is a perfect tool for promoting an active lifestyle without compromising work responsibilities. Prolonged sitting has been linked to numerous health issues, but with the COZYINN Walking Pad, users can integrate movement into their daily routines, boosting productivity, energy, and overall well-being.

The treadmill also includes a phone holder, making it easy for users to multitask by participating in conference calls or watching content while exercising.

Customer Testimonials: A Game-Changer for Fitness

COZYINN has already received rave reviews from customers who have experienced the benefits of the Walking Pad.

“I love this product! It allows me to get extra steps throughout the day, and I can even jog on it. The size fits perfectly under my desk, and it’s not too noisy, which is great for my work environment. It’s also great value for the price,” says Jennifer, a verified Amazon customer.

Another satisfied customer, Varuca Salty, adds: “This is the perfect treadmill for someone who wants to get their steps in every day with no hassle. It is lightweight but sturdy. I walk 4-5 days a week for 30 minutes. It is a very quiet machine, and the walking motion is smooth.”

Pricing and Availability

The COZYINN Walking Pad Under Desk Treadmill is now available on Amazon, offering free delivery to your doorstep. To learn more about the product, visit the official COZYINN Amazon product page here.

About COZYINN

COZYINN is dedicated to developing innovative fitness products that improve the quality of life for individuals worldwide. By combining advanced technology with practical design, COZYINN provides high-performance, user-friendly fitness solutions that cater to the needs of modern, health-conscious consumers.

Product link: https://www.amazon.com/dp/B0CH9JK63X

Media Contact

Organization: COZYINN.

Contact Person: DREAMER

Website: https://www.amazon.com/dp/B0CH9JK63X

Email: Send Email

City: california

Country: United States

Release Id: 05102417969

The post COZYINN Introduces the 2-in-1 Folding Walking Pad with Incline: The Ultimate Under Desk Treadmill for Home and Office Fitness appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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Law Offices of R. Ross Jacinto Expands Prenuptial Agreement Services in Pasadena to Enhance Financial Security for Couples

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Today, it’s just the rich and famous who decide on having a plan to protect their assets before they say, “I do.” It is equally important for couples of various income levels to protect any assets they own before tying the knot.

The Law Offices of R. Ross Jacinto, a trusted name in family law, is proud to announce an expanded focus on drafting prenuptial agreements for couples residing in the Pasadena, CA, area. Couples can count on the Law Offices of R. Ross Jacinto Prenuptial Agreement Attorney legal services for personalised and detailed marital agreements that are legally sound and enforceable to protect their financial futures.

Specialising in protecting personal assets, businesses, and inheritances, the firm provides a seamless experience for couples seeking clear financial agreements before marriage.

Ross Jacinto, lead attorney and founder, commented on the growing demand for prenuptial agreements: “A well-developed prenuptial agreement can be invaluable. It allows engaged couples to enter into the marriage with openness and mutual understanding about their finances. Our goal is to ensure that clients feel safe and protected with agreements that fit their specific needs.”

A Fundamental Service for Financial Peace of Mind

Prenuptial agreements should not be thought of as a niche service only meant for couples of a certain status. Couples should think of them as smart financial planning for the unexpected without guilt or reservation.

In fact, a prenup agreement is the first step in establishing open and honest communication with your future spouse; and we know that communication is a major factor in having a healthy and happy marriage.

The Law Offices of R. Ross Jacinto provides expert legal counsel in making sure that each agreement reflects the unique financial circumstances of both parties. Whether dealing with premarital assets, business ownership, or future inheritances, the firm’s individualized approach guarantees that every client receives the attention necessary to create enforceable agreements that guard their interests.

Marin services offered by the Law Offices of R. Ross Jacinto include:

  • Drafting Personalised Prenuptial Agreements: Every agreement is customized to meet the specific financial and personal requirements of the couple.
  • Expert Legal Advice: Comprehensive consultations that consider asset division, property rights, and future financial expectations.
  • Modifying Existing Prenuptial Agreements: Revising prenuptial agreements to reflect changing financial situations or evolving personal needs.

Expertise in Local Prenuptial Agreement Services

In response to the increasing demand for prenup agreements among couples in the Pasadena area, the Law Offices of R. Ross Jacinto give extraordinary expertise in this field. The firm heightens its services to support couples in establishing clear expectations and protecting their rights as they enter into marriage. Couples can expect confidentiality, professionalism, and sound legal advice throughout the process.

Why Choose Law Offices of R. Ross Jacinto Before Getting Married?

The Law Offices of R. Ross Jacinto has built a reputation for its sympathetic and individual approach. It is known as a reliable legal choice for anyone seeking guidance in a variety of family law legal matters, including marital agreements.

Drawing on years of experience in the field, Ross Jacinto stated, “Couples come to us because they know we will handle their cases with the greatest care and professionalism. We are determined to deliver agreements that give both parties the peace of mind they deserve.”

About the Law Offices of R. Ross Jacinto

The Law Offices of R. Ross Jacinto provide comprehensive family law services, including divorce, child custody, child and spousal support, legal separation, restraining orders, and property settlements. They offer compassionate legal guidance tailored to each client’s needs, whether it involves establishing paternity rights or handling domestic violence cases. With over 30 years of experience, Ross Jacinto is dedicated to helping clients navigate complex family law matters with empathy and expertise. For more information.

Media Contact

Organization: Law Offices of R. Ross Jacinto

Contact Person: Ross Jacinto

Website: https://www.rossjacinto.com/

Email: Send Email

Contact Number: +16263041001

Address: 540 El Dorado Street # 202 Pasadena, CA 91101

Country: United States

Release Id: 05102417959

The post Law Offices of R. Ross Jacinto Expands Prenuptial Agreement Services in Pasadena to Enhance Financial Security for Couples appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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Sonia Borrell Celebrates Book Launch, Art in Real-Time, Hitting Amazon Bestseller List In Just Days

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Art Collector, Curator, and Advisor Sonia Borrell shares 16 years of experience in the contemporary art world through her debut book.

London, United Kingdom, 5th Oct 2024 – Internationally renowned art collector and curator Sonia Borrell recently launched her first book, Art in Real-Time: Collecting Tomorrow’s Masters, in mid-September. Becoming an Amazon bestseller and quickly capturing the attention of art collectors and enthusiasts worldwide, she further bagged number one bestseller position in various categories, including Business in Art and Women in Art, for both Kindle and hardcover formats, within two days of its launch, making her the top author in this genre across Europe and the USA. The book is a part-guide, part-memoir aimed towards young collectors and artists to learn how to develop their taste, get involved in collecting, and navigate the industry. It embodies Sonia Borrell’s philosophy of art collecting—viewing art as a way of living and believing that these young artists are, and will be, as impactful as those before them.
 

Available for purchase on Amazon, it offers a comprehensive guide for art collectors, curators, and enthusiasts who want to deepen their understanding of the Ultra-Contemporary Art movement, also known as the “New-Now.” With contributions from leading figures in the art world, Art in Real-Time provides unique insights into the fast-paced and ever-evolving art industry.

Borrell, whose extensive collection includes works from some of the world’s most acclaimed contemporary artists, such as Takashi Murakami and Yoshitomo Nara, brings her decades-long expertise into a detailed and practical format for readers. Her career has seen her curating exhibitions worldwide, advising high-profile clients, and contributing to the development of art scenes in regions like the Middle East, where she has been actively involved in nurturing artistic talent.

Art in Real-Time is not only a guide but also a memoir that highlights Borrell’s personal experiences as she navigated the art world, built relationships with artists, and developed an influential collection. Readers will find step-by-step advice on how to start their own art collections, no matter the budget—whether starting at minimum or extending into six figures. In addition, Borrell addresses essential topics such as recognizing market trends, engaging with galleries, and the importance of building relationships with artists.

The book features an eclectic array of chapters that weave together Sonia Borrell’s personal insights and the expertise of distinguished contributors from across the global art community.

It begins with introspective discussions on learning, cultural exposure, and the profound impact of art in real-time, before exploring the intricacies of building meaningful collections with various budgets. The chapters provide a roadmap for collectors of all levels, diving deep into practical aspects such as navigating art galleries, engaging with artists, and understanding the dynamics of the art market. Contributions from industry experts enrich the narrative, offering diverse perspectives on everything from collecting wishlists and social networks within galleries to mastering artistic collaborations and navigating the often hidden challenges of art flipping. The book also tackles contemporary issues such as the pandemic’s impact on the art world and the importance of preserving art through contracts. Each chapter serves as a nuanced exploration into the multifaceted world of art collecting, culminating in a masterclass for both aspiring artists and collectors.

A Collaborative Effort from the Art World’s Finest
The book also includes contributions from notable art professionals such as Géraldine Zberro, Carl Kostyál, and August Vilella. These voices offer a rich array of perspectives, covering everything from understanding the inner workings of galleries to protecting the integrity of the art market.

Borrell’s own journey has spanned global art markets and trends, and her work has been featured in museums such as the Thyssen-Bornemisza National Museum in Madrid and the Kyoto City KYOCERA Museum of Art. She has also garnered significant media attention, with features in publications like GQ Middle East and Harper’s Bazaar. Her deep involvement in fostering contemporary art in Saudi Arabia, particularly through her advisory role at The Althari Group, further positions her as a prominent figure in today’s art scene.

Art in Real-Time will be officially launched on Amazon in mid-September 2024. The digital version will be available for worldwide shipping, ensuring access to readers and art lovers globally.

“I wanted to create a resource that would resonate with anyone who has a passion for art,” says Borrell. “The book is designed for collectors, curators, and anyone with a desire to learn more about the art world—whether you’re just getting started or already deep in the scene.”

About Sonia Borrell
Sonia Borrell is an internationally recognized art collector, curator, advisor, and founder of the Tryson Collection, established in 2008. With a Master’s degree in Law from the University of Barcelona (UAB), she has built a multifaceted career that bridges the legal, entrepreneurial, and creative worlds. Her brand is dedicated to discovering and uplifting new talent in the Ultra-Contemporary Art scene, making her a pivotal figure in the modern art community.

 

Media Contact

Organization: Tryson Collection

Contact Person: Alexander Grindheim & Marwan Kamel

Website: http://www.trysoncollection.com

Email: admin@trysoncollection.com

City: London

Country: United Kingdom

Release Id: 05102417289

The post Sonia Borrell Celebrates Book Launch, Art in Real-Time, Hitting Amazon Bestseller List In Just Days appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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