Press Release
Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer
–News Direct–
By Jeremy Golden, Benzinga
Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.
The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).
Very encouraging results were recently reported by the Needham, Massachusetts-based company.
Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).
No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.
Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.
Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.
Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.
CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.
Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.
The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.
Featured photo by National Cancer Institute on Unsplash.
Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.
This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.
This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.
Contact Details
Aljanae Reynolds
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Company Website
View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953
Candel Therapeutics
COMTEX_453283087/2655/2024-06-03T08:31:08
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Dubai, United Arab Emirates, 4th Apr 2025 – Vista Finance Token has made waves in the cryptocurrency market, surging from $2 to $44, boasting a fixed supply of 21 million tokens, and laying out an ambitious roadmap. With a dramatic 95% token burn scheduled for May 2025, upcoming listings on prominent exchanges, and a diverse ecosystem covering NFTs, fitness, and mining, Vista aims to establish itself as a key player in decentralized finance. But does this explosive growth reflect lasting potential or just short-term hype?
From $2 to $44: A Promising Surge
Vista’s price increase—jumping 22 times in value—demonstrates strong market interest. Its capped supply of 21 million tokens contributes to scarcity, supporting price appreciation. While the exact timeline of this rise isn’t specified, it’s likely fueled by investor anticipation of future developments. However, past performance isn’t always an indicator of future gains. Sustainable success depends on how well the project executes its roadmap.
The 95% Token Burn: A Bold Bet on Scarcity
Vista’s most aggressive strategy is its May 2025 token burn, reducing supply from 21 million to just 1.05 million tokens. Token burns are a common deflationary mechanism; Binance Coin (BNB) and Shiba Inu have used them successfully to drive long-term value. However, Vista’s burn is extreme. If demand remains high, prices could skyrocket, benefiting holders. However, if hype fades, the reduced supply could lead to low liquidity and an unstable market. The burn must be backed by real demand for Vista’s ecosystem.
Exchange Listings: Expanding Market Reach
Currently, Vista is listed on XT.com, ProBit Global, Vindex, Nexdex, and Bank CEX. These platforms provide liquidity but lack the influence of top-tier exchanges. In May 2025, Vista plans to expand to MEXC, BitMart, and P2B—larger exchanges that could attract institutional investors. While listings help increase visibility, they don’t guarantee long-term success without real-world utility.
Ecosystem Development: More Than Just a Token
Vista isn’t relying solely on tokenomics—it’s building an ecosystem. In May 2025, an NFT marketplace and game will launch, allowing users to trade digital assets and make in-game purchases with Vista tokens. While blockchain gaming and NFTs are trending, competition is fierce. To succeed, Vista must offer unique
Media Contact
Organization: View finance dapps solution
Contact Person: Dharmender Singh
Website: https://vistafinance.io/
Email: Send Email
City: Dubai
Country:United Arab Emirates
Release id:26019
View source version on King Newswire:
Vista Finance Token: A Rising Star in the Crypto Market Poised for Growth
It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Dubai, United Arab Emirates, 4th Apr 2025 – Vista Finance Token has made waves in the cryptocurrency market, surging from $2 to $44, boasting a fixed supply of 21 million tokens, and laying out an ambitious roadmap. With a dramatic 95% token burn scheduled for May 2025, upcoming listings on prominent exchanges, and a diverse ecosystem covering NFTs, fitness, and mining, Vista aims to establish itself as a key player in decentralized finance. But does this explosive growth reflect lasting potential or just short-term hype?
From $2 to $44: A Promising Surge
Vista’s price increase—jumping 22 times in value—demonstrates strong market interest. Its capped supply of 21 million tokens contributes to scarcity, supporting price appreciation. While the exact timeline of this rise isn’t specified, it’s likely fueled by investor anticipation of future developments. However, past performance isn’t always an indicator of future gains. Sustainable success depends on how well the project executes its roadmap.
The 95% Token Burn: A Bold Bet on Scarcity
Vista’s most aggressive strategy is its May 2025 token burn, reducing supply from 21 million to just 1.05 million tokens. Token burns are a common deflationary mechanism; Binance Coin (BNB) and Shiba Inu have used them successfully to drive long-term value. However, Vista’s burn is extreme. If demand remains high, prices could skyrocket, benefiting holders. However, if hype fades, the reduced supply could lead to low liquidity and an unstable market. The burn must be backed by real demand for Vista’s ecosystem.
Exchange Listings: Expanding Market Reach
Currently, Vista is listed on XT.com, ProBit Global, Vindex, Nexdex, and Bank CEX. These platforms provide liquidity but lack the influence of top-tier exchanges. In May 2025, Vista plans to expand to MEXC, BitMart, and P2B—larger exchanges that could attract institutional investors. While listings help increase visibility, they don’t guarantee long-term success without real-world utility.
Ecosystem Development: More Than Just a Token
Vista isn’t relying solely on tokenomics—it’s building an ecosystem. In May 2025, an NFT marketplace and game will launch, allowing users to trade digital assets and make in-game purchases with Vista tokens. While blockchain gaming and NFTs are trending, competition is fierce. To succeed, Vista must offer unique
Media Contact
Organization: View finance dapps solution
Contact Person: Dharmender Singh
Website: https://vistafinance.io/
Email: Send Email
City: Dubai
Country:United Arab Emirates
Release id:26019
View source version on King Newswire:
Vista Finance Token: A Rising Star in the Crypto Market Poised for Growth
It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
In the turbulent sea of the cryptocurrency market, LWEX Exchange has rapidly risen to prominence, thanks to its innovative business model and robust technological prowess. However, trust issues and ecosystem fragmentation have long plagued the industry. By introducing the “Triple-Win Ecosystem Model,”
LWEX has successfully addressed the core contradictions of traditional exchange models, achieving a virtuous cycle of user returns, platform profitability, and ecosystem co-construction. This article delves into LWEX Exchange’s current status and future plans, exploring its position and potential within the industry.
I. Current Status: From Trust Crisis to Industry Benchmark
1. User Base and Trading Volume
LWEX Exchange currently boasts over 50 million registered users, with more than 3 million daily active traders. In the first quarter of 2023, it recorded a trading volume of $42 billion, securing its place among the global top 15. These figures not only reflect its competitiveness in the market but also signify the growing trust users place in the platform. The rapid expansion of its user base is attributed to LWEX’s continuous investments in technological innovation, user experience optimization, and market promotion.
2. Technology and Security Measures
LWEX, with the strong support of its parent company,has introduced a dual guarantee mechanism of “user asset custody + dynamic return model.” By utilizing an FCA-regulated cold wallet system, LWEX eliminates the risk of user asset theft from the outset, providing a secure and reliable trading environment. Additionally, LWEX has implemented multi-factor authentication, cold/hot wallet separation, and real-time monitoring to further enhance fund security.
3. Compliance Layout
LWEX has been continuously reviewing and obtaining relevant qualifications in terms of compliance, and is actively applying for them across various regions nationwide.This global compliance strategy not only paves the way for market expansion but also lays a solid foundation for long-term development. Compliance is key to the sustainable development of the cryptocurrency market, LWEX has enhanced its compliance capabilities and market influence through collaborations with major global institutions.
II. Future Planning: A Strategic Layout for Globalization and Ecosystem Building
1. User Growth and Market Expansion
LWEX aims to serve 100 million global users across over 200 countries and regions by 2025. The achievement of this goal will rely on its strong localized service capabilities and in-depth exploration of emerging markets. Through collaboration with GS Investment Group, LWEX has attracted 600,000 loyal users with an 82% retention rate, providing strong momentum for future user growth. LWEX will employ the following strategies to achieve user growth:
Localized Services: Tailor language support, payment methods, and compliance services to meet the demands of different countries and regions.
Market Promotion: Increase brand awareness through a combination of online and offline promotional efforts.
User Incentives: Introduce diverse user incentive mechanisms, such as referral rewards and trading rebates, to attract more users.
2. Technological Innovation and Ecosystem Co-Construction
LWEX will continue to refine its AI quantitative strategies to optimize user return mechanisms and enhance fund security through technologies like cold/hot wallet separation and multi-factor authentication. Additionally, LWEX plans to launch more innovative trading tools, such as derivatives trading and decentralized finance (DeFi) products, to meet users’ diverse investment needs.
AI Quantitative Strategies: Leverage artificial intelligence and big data technologies to develop more precise trading strategies for stable user returns.
Decentralized Finance (DeFi): Explore innovative DeFi applications like decentralized lending and liquidity mining to offer users a richer array of investment options.
Ecosystem Co-Construction* Collaborate with high-quality projects in the industry to build an open, transparent, and sustainable ecosystem.
III. In-Depth Analysis: LWEX Core Competitiveness and Industry Impact
1. Core Competitiveness
LWEX Exchange’s core competitiveness lies in its innovative business model, robust technological capabilities, and global compliance strategy. The “Triple-Win Ecosystem Model” enables the coordinated development of users, the platform, and the ecosystem. Support from its parent company, GS Investment Group, provides LWEX with solid technological and financial backing. Moreover, LWEX’s continuous investments in compliance give it a unique competitive edge in the global market.
2. Industry Impact
The rise of LWEX Exchange is not only the result of technological and business model innovation but also a reflection of its deep understanding of industry pain points and precise grasp of user needs. During the industry’s transition from the “Wild West” phase to a regulated era, LWEX has provided a trustworthy digital asset trading platform for global users through technological innovation, compliance布局, and ecosystem building. Its successful experience offers valuable lessons for the industry and drives the healthy development of the entire cryptocurrency market.
3. Future Outlook
LWEX Exchange’s future plans reveal its strategic layout for globalization and ecosystem building. Through technological innovation and compliance expansion, LWEX is not only poised to achieve its goals of user and market growth but will also play a significant role in promoting the sustainable development of the cryptocurrency market. The global and ecosystem-oriented digital asset ecosystem it constructs will deliver a safer, more convenient, and richer investment experience for users.
IV. Conclusion: From Trading to Ecosystem, Building the Future of Digital Assets
The rise of LWEX Exchange is the result of technological and business model innovation, as well as its deep understanding of industry challenges and user needs. During the critical transition of the cryptocurrency market from the “Wild West” phase to regulated territories, LWEX has provided a trustworthy platform for global users through technological innovation, compliance efforts, and ecosystem building.
Looking ahead, LWEX will continue to prioritize users, use compliance as its foundation, and drive innovation to build a global and ecosystem-oriented digital asset ecosystem. Choosing LWEX is not just selecting a trading platform but embracing a new era’s certainty — a place where risk control and wealth growth are no longer at odds, and trust and innovation jointly shape the future. LWEX Exchange’s vision is not only to become a leading global digital asset trading platform but also to be a driving force behind the industry’s move toward a safer, more transparent, and sustainable future.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Vista Finance Token: A Rising Star in the Crypto Market Poised for Growth
Vista Finance Token: A Rising Star in the Crypto Market Poised for Growth
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