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Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer

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–News Direct–

By Jeremy Golden, Benzinga

Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.

The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).

Very encouraging results were recently reported by the Needham, Massachusetts-based company.

Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).

No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.

Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.

Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.

Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.

CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.

Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.

The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.

Featured photo by National Cancer Institute on Unsplash.

Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.

This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.

This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.

Contact Details

Aljanae Reynolds

+1 617-916-5445

areynolds@wheelhouselsa.com

Company Website

https://www.candeltx.com/

View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953

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Shop Better, Save Big: BetterFinds.com.au Unveils Black Friday Deals

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Melbourne, Australia

www.BetterFinds.com.au

BetterFinds.com.au, your go-to destination for premium quality and uniquely designed products, is thrilled to announce its highly anticipated Black Friday deals. This year, we’re bringing you unbeatable offers on must-have products from our curated collection of emerging and established brands.

From STRAHL’s durable, shatterproof glassware to Generation Earth eco-friendly bags and stylish laptop sleeves, there’s something for everyone—whether you’re shopping for gifts or treating yourself.

Black Friday Highlights at BetterFinds.com.au:

STRAHL Glassware: Save up to 35% on premium, shatterproof glassware—perfect for summer entertaining.

ClickClack Offer: Receive a free tote bag with ClickClack orders over $100.

Incredible Prices Across Categories: Discover homewares, bags, laptop sleeves and more starting at just $10.

Shop now and find thoughtful gifts or timeless essentials that combine purpose, function, and beauty.

About BetterFinds.com.au?

BetterFinds.com.au is an Australian online store focusing on emerging quality brands and unique design. Each piece we carry brings together purpose, function, and beauty. We look for products that solve problems, use reclaimed or recycled materials, and showcase 

exceptional craftsmanship. Some of our items are designed by our in-house team, ensuring they meet the same high standards of quality.

BetterFinds.com.au is a place for gift shopping when you want find something different to bigger brand offering. Our collection of brands include Stackers, EVOL, Generation Earth, STRAHL, ClickClack, Urburn.

Shop the sale now: https://betterfinds.com.au/collections/black-friday

For media inquiries, please contact BetterFinds.com.au from our online store.

About BetterFinds.com.au

BetterFinds.com.au is an Australian online store committed to showcasing emerging quality brands and unique designs. Each product in our collection is thoughtfully chosen for its purpose, craftsmanship, and beauty. Whether you’re looking for a one-of-a-kind gift or a product that solves everyday problems, BetterFinds.com.au offers a refreshing alternative to the big retail sites.

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Faith, Fight, and Fire: Forge a Life of Relentless Strength

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William G. Alston’s New Book Reveals the Secrets to Achieving Peak Performance and Balance in Life

Are you ready to unlock the pathway to ultimate health, fitness, and unwavering faith? Dr. William G. Alston’s groundbreaking new book, Four Keys to the Natural Anabolic State: The Pathway to Health, Fitness, Faith, and a Huge Competitive Edge, is more than just a guide—it’s a manifesto for those who crave control over their bodies, minds, and spirits.

In today’s fast-paced world, chronic stress and anxiety are taking a toll on millions, but Dr. Alston is here to show you how to reclaim your power. This book doesn’t rely on fleeting trends or empty promises. Instead, it offers a scientifically proven method to unlock your body’s natural anabolic state—a biochemical process that empowers you to perform at your peak in every area of life.

Whether you’re an athlete looking for a competitive edge, a student striving for academic excellence, or a professional seeking balance, Four Keys to the Natural Anabolic State equips you with the tools to manage stress, overcome fear, and maximize performance. By integrating faith, fitness, and a focus on your mental fortitude, Dr. Alston guides you through practical steps that turn stress into empowerment, fear into action, and fatigue into strength.

This isn’t just another self-help book—it’s a transformation. Dr. Alston uses decades of research to lay out the four critical keys that will help you harness your body’s God-given potential. He provides a powerful, yet simple roadmap for anyone looking to sharpen their focus, build resilience, and thrive in life.

Packed with cutting-edge insights on the stress-response system, real-life examples, and strategies for immediate application, this book shows you how to flip the switch from chronic worry to anabolic empowerment. It’s time to rise above stress, claim your strength, and tap into a life full of vitality, faith, and unstoppable energy.

Key Highlights:

  • Learn to control your stress-response system for peak performance
  • Discover the connection between anxiety, performance, and faith
  • Get practical tools for building physical strength, mental clarity, and spiritual peace
  • Ideal for athletes, professionals, students, and anyone seeking self-mastery

Meet Dr. William G. Alston 

Dr. William G. Alston is an acclaimed author, PhD, and fitness expert who has spent years studying the human mind-body connection. His passion for helping others achieve their fullest potential shines through in every chapter of this book.

Four Keys to the Natural Anabolic State is available now from Universal-Publishers.

For more information or to schedule an interview with Dr. William G. Alston, please contact:

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Knowledge Is Power: Minority Class Registers With State

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Chantal Smith organizer of On The Way Ventures L.L.C. An African  American mother and licensed Masseuse captured the images used  discovering the electrolyte formula (-100v x propagation). Collecting  10$ every month is not easy without capital, OTW Ventures L.L.C. will  not disappear and that is the classes only decision. Callers dial (347) 356  – 7730 expecting greatness and new beginnings the staff remains tough  despite the onslaught of callers.  

 She noticed that traditional electrolyte solutions were not providing the  desired results and decided to take matters into her own hands. With the  help of her team at OTW Ventures L.L.C., Chantal was able to develop a  

formula that not only replenishes electrolytes but also improves overall  hydration levels. Despite the challenges of collecting only $10 per  month from their subscribers, the company has remained steadfast in  their commitment to their projects. With the release of this revolutionary  electrolyte formula, OTW Ventures L.L.C. is confident that they will  continue to thrive and provide their subscribers with top-notch products.  The demand for this new electrolyte formula has been overwhelming,  with callers dialing (347) 356 – 7730 in hopes of getting their hands on  it.  

Despite the onslaught of inquiries, the staff at OTW Ventures L.L.C.  remains dedicated and determined to provide their customers with the  best possible service. With this new discovery, the company is expecting  a surge in subscribers and is excited to see the positive impact it will  have on people’s lives. The images captured by Chantal and her team  will be released to the public next month, along with the electrolyte  formula. OTW Ventures L.L.C. is confident that this discovery will  revolutionize the electrolyte market and improve the lives of many.  

In today’s increasingly digital world, “on the way”has become  more important than ever. As we continue to incorporate 

technology into every aspect of our lives, from personal devices  to complex corporate networks, the need to protect these  systems from cyber threats is paramount “otw” is not just a  buzzword; It is at the heart of our digital lives, ensuring privacy,  integrity and availability of data and systems.  

What is “on the way”? 

“on the way” is the process of protecting computers, servers,  mobile devices, electronic systems, networks, and data from  malicious attacks. This includes a wide range of practices,  technologies and procedures designed to protect networks,  devices, systems and data from attack, damage or unauthorized  access.  

“on the way” can be broken down into several main areas: 

Network Security – Protects the integrity, privacy, and  availability of data on or between networks.  

Information Security – Focuses on protecting the  confidentiality, integrity and security of existing data stored and  transmitted.  

Application Security – Includes protecting applications by  identifying, repairing, and preventing security vulnerabilities.  • Endpoint Security – Refers to the security of personal devices  such as laptops, desktops, and mobile devices connected to a  network.  

Identity Management – Includes processes, policies, and  technologies that ensure only authorized individuals have access  to information systems. 

Cloud Security – Refers to protecting data, applications, and  services in the cloud from cyber threats.  

Trends in cyber terrorism 

Cyber threats have evolved dramatically over the years. Initially,  “otw” threats were relatively simple, with hackers targeting  single systems or small networks. But as technology has  advanced, so have threats. Modern cyberattacks are often  sophisticated, targeting entire infrastructure, supply chains, and  even critical national assets.  

1. Malware 

One of the most common cyber threats, malware is malicious  software designed to harm or exploit any programmable device,  service, or network. This includes viruses, worms, Trojans,  ransomware and spyware.  

2. Phishing 

This is a common social engineering attack used to steal user  data, including login credentials and credit card numbers. It  occurs when an attacker impersonates a trusted user in an  electronic communication.  

3. Ransomware 

A type of malware that locks users out of their systems or files  and requires a ransom to regain access. High-profile  ransomware attacks have crippled businesses and governments  alike.  

4. Advanced Persistent Threats (APTs)

These are long-term and targeted cyberattacks in which the  attacker gains access to a network and remains undetectable for  long periods of time, often targeted stop data theft  5. Distributed denial of service (DDoS) attacks  This type of attack overwhelms a system, server, or network  with traffic, making it unavailable.  

The importance of “on the way” 

The consequences of a successful cyberattacks can be  devastating for individuals and organizations. For businesses,  breaches can result in significant financial losses, legal  ramifications and reputational damage. For individuals,  cyberattacks can result in identity theft, data loss, and financial  loss.  

• Unauthorized access or disclosure of sensitive data can have  serious consequences, especially if the data is of a personal or  financial nature  

• The costs associated with a cyberattacks can be significant.  Companies can face high costs, legal costs, and expenses for  broken systems.  

• A cyberattacks can severely damage an organization’s  reputation, leading to loss of customer trust and decline in  productivity.  

• Cyber-attacks can disrupt business operations, resulting in  downtime, lost productivity and lost business opportunities.  

“on the way” best practices

Adopting strong “otw” practices is essential to protect against  cyber threats. Here are some best practices for individuals and  organizations to follow.  

• Ensure that all software, including operating systems,  applications, and security programs, are regularly updated to  protect against known vulnerabilities  

• Implement strong password management, including the use of  strong passwords and multi-factor authentication (MFA).  • Conduct regular “otw” training for employees to help them  identify and avoid potential threats such as phishing scams.  • Protect sensitive data with encryption while traveling and on  vacation, ensuring that data cannot be read by unauthorized  parties even if it is blocked  

• Make sure you back up important data regularly and make sure  these backups are stored securely and are easily accessible in the  event of a cyberattacks.  

• Develop and implement robust incident response plans to  promptly address any security breaches and minimize impact.  

The Future of Cybersecurity 

As technology continues to evolve, so too will the threats that  we face. The rise of artificial intelligence (AI), the Internet of  Things (IoT), and cloud computing introduces new challenges  for “on the way”. However, these technologies also offer new  opportunities for enhancing security.  

a. AI in “on the way” 

AI can be used to identify patterns and anomalies in large data  sets, enabling the early detection of potential threats. Machine 

learning algorithms can also help in developing more  sophisticated security systems.  

b. IoT Security 

With the proliferation of IoT devices, securing these  interconnected systems will become increasingly important. It  will require the development of new protocols and standards to  ensure that IoT devices are not vulnerable to cyber-attacks.  

c. Cloud Security 

As more organizations migrate to the cloud, ensuring the  security of cloud-based systems will be paramount. This will  involve adopting new cloud security frameworks and best  practices.  

Conclusion 

“on the way” is a top priority in the digital age. As we embrace  technology, the need for stronger cyber security measures will  increase. By understanding risks, notifying us of emerging  threats, and adopting best practices, individuals and  organizations can protect themselves from ever-changing cyber  threats The future of “otw” depends on us the ability to adapt  and innovate to ensure we can protect the digital frontier for  generations to come. 

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