Press Release
Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer
–News Direct–
By Jeremy Golden, Benzinga
Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.
The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).
Very encouraging results were recently reported by the Needham, Massachusetts-based company.
Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).
No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.
Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.
Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.
Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.
CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.
Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.
The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.
Featured photo by National Cancer Institute on Unsplash.
Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.
This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.
This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.
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View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953
Candel Therapeutics
COMTEX_453283087/2655/2024-06-03T08:31:08
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Press Release
ONIX Exchange Focuses on Building a Safe and Efficient Digital Asset Ecosystem
ONIX Exchange further solidifies its position as an industry leader through its unique development model and user-centric philosophy, completely disrupting the traditional paradigm of cryptocurrency trading. Unlike many exchanges that rely on large-scale external promotions and celebrity endorsements, ONIX is committed to building an ecosystem with a stronger sense of community belonging by fairly distributing transaction fees and returning them to users.
Each transaction fee on the ONIX platform is not only allocated back to new members fairly but also used to cover various tax obligations, ensuring that every transaction on the platform complies fully with tax regulations. This innovative approach not only protects users’ financial security but also eliminates potential risks arising from untaxed profits. By assuming the tax responsibilities for transactions, ONIX enables users to focus on their trading activities without worrying about potential tax issues in the future. This commitment to financial security underscores ONIX’s deep dedication to users’ long-term interests.
Choosing ONIX means joining a fair and transparent distribution system and enjoying peace of mind from tax exemption. ONIX adopts a different strategy by channeling resources into genuinely enhancing user experience and security rather than chasing gimmicks and market visibility. This substance-focused value is a core principle of ONIX and a key differentiator from other exchanges
Security is the pillar of ONIX Exchange’s mission. Recognizing the critical importance of trust in the digital asset space, the platform has implemented state-of-the-art security measures to protect user funds and data. Multi-layered encryption, advanced fraud detection systems, and constant monitoring ensure that users can trade with peace of mind. Moreover, by adhering to rigorous regulatory standards, ONIX Exchange reinforces its commitment to transparency and compliance, further enhancing its reputation as a trusted trading platform.
At the core of ONIX Exchange’s security infrastructure is its adoption of cutting-edge blockchain technology. By leveraging the decentralized and transparent nature of blockchain, ONIX ensures that all transactions are immutable and fully traceable, reducing the risk of tampering or fraudulent activity. This foundational layer of blockchain security is enhanced by ONIX’s implementation of advanced encryption protocols, which protect user data and funds from unauthorized access.
To further safeguard its users, ONIX Exchange employs multi-signature wallets for fund storage, ensuring that no single entity has unilateral access to user assets. This practice significantly minimizes the risk of asset theft, as multiple approvals are required for any transaction involving stored funds. Additionally, the platform integrates cold storage solutions, keeping the majority of assets offline and away from potential online vulnerabilities. These measures collectively form a robust framework that prioritizes user safety above all else.
ONIX Exchange also implements real-time monitoring systems that actively track all activities on the platform to detect and prevent potential threats. Using artificial intelligence and machine learning algorithms, the platform identifies unusual patterns and flags suspicious transactions, enabling immediate intervention before any damage can occur. This proactive approach demonstrates ONIX’s commitment to staying ahead of emerging security challenges and protecting its users from evolving cyber threats.
Compliance with global regulatory standards is another cornerstone of ONIX Exchange’s security strategy. By adhering to Know Your Customer (KYC) and Anti-Money Laundering (AML) protocols, the platform ensures that only verified and legitimate participants can access its services. This not only reduces the risk of fraud but also fosters a transparent and trustworthy trading environment. ONIX actively collaborates with international regulatory bodies to maintain the highest compliance standards, further strengthening its reputation as a secure and reliable exchange.
To enhance user confidence, ONIX Exchange offers comprehensive insurance coverage for digital assets stored on its platform. This guarantees that users are protected against unforeseen events, providing an additional layer of reassurance. By taking this step, ONIX demonstrates its dedication to mitigating risks and offering peace of mind to its growing user base.
In addition to platform security, ONIX Exchange emphasizes educating its users about best practices for safeguarding their accounts. The platform provides detailed guides and resources on securing personal wallets, recognizing phishing attempts, and maintaining strong authentication measures. By empowering its community with knowledge, ONIX ensures that users can actively contribute to their own security, creating a safer overall ecosystem.
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As ONIX Exchange continues to expand its digital asset ecosystem, its focus on security remains paramount. The platform’s innovative technologies, regulatory compliance, and user-centric strategies are not only addressing current challenges but also shaping the future of secure digital asset trading.
ONIX’s commitment to regulatory compliance further enhances its position as a trustworthy global platform. By adhering to international standards and collaborating with regulatory bodies, ONIX ensures a secure and compliant trading environment. This proactive approach not only builds trust among users but also sets an example for how crypto platforms can operate responsibly on a global scale.
As ONIX Exchange continues to expand its global footprint, its focus on innovation, security, and user satisfaction ensures that it remains a formidable competitor to traditional exchanges. By addressing the limitations of legacy systems and leveraging the unique capabilities of blockchain technology, ONIX is not only creating an outstanding crypto trading platform but also shaping the future of digital finance.
Contact name: Jason Scott
Company name: Onix Exchange
Website : https://on-ix.tr/
Country: USA
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Press Release
“2025 Rising Miners Cloud : Rickys Booster Delivers Professional-Grade Services for Miners in 2025”
2025 new year, top tier group mining system Rickys Booster is launched with world top +300 wallets such as Binance, Bybit, Okx, Bitget, Metamask, Trustwallet and etc. In the Binance Square, Rickys got featured before launching already and currently doing the revolutionizing cryptocurrency mining for mining farms, proposing new and large-scale mining farms that target efficiency and profitability of miners. This modern infrastructure conveys progressive features of mining utilities, combined with sustainable solutions that provide a holistic experience.
BTC profitability is going high like 180% recent years, early stage miners already took a lot. As a scalable mining offering with strong performance and reliability, Rickys Booster mining farms will meet any level of miner’s needs. In 2025 cloud farms are employing the most advanced mining technologies, which provide unprecedented hashrate power together with the wise usage of resources. This combination makes it possible for miners to actually accomplish their goals without necessarily sacrificing cost or sustainability.
That is why Rickys Booster, as a leader of the cryptocurrency mining industry, will help miners to obtain reliable and innovative solutions. Our mining farms are designed to be a force multiplier in the digital currency landscape to ensure that those who invest in mining have a powerful and sustainable platform to thrive on.
Mining Farm Highlights:
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The mining farms by Rickys Booster are fit for miners and investors who are interested in secure, efficient and easy to expand Ministry Solutions. To know more about the future of cryptocurrency mining visit www.rickysbooster.com.
Contact Name : Ricky Seo
Position : Founder
Name : Ricky Seo
Company : Rickys Booster
Website : Rickysbooster.com
Email : info@rickysbooster.com
City: Sharjah Address: 72367, Al Messaned,Al Mitsannid,Sharjah, UAE
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Bee Short Leading the Global Wave of Short Drama Entertainment and Wealth Creation
China, 7th Jan 2025 – In today’s fast-paced world, short videos have become an essential part of our entertainment lives. Short dramas, with their concise plots, tightly woven narratives, and immense appeal, are quietly rising to prominence. As a pioneer in the short drama industry, Bee Short not only redefines the viewing experience but also paves a new path to wealth creation.
The Rise of Short Dramas: Leading a New Entertainment Trend
Short dramas, combining storytelling and entertainment, have become a favorite among global youth. Compared to traditional films and TV shows, short dramas offer immediacy and interactivity. In just 3 to 5 minutes, a complete story unfolds, covering genres like romance, suspense, workplace drama, and time travel, meeting the fragmented entertainment needs of modern audiences.
With its extensive library of high-quality content, precise user-matching technology, and multilingual support, Bee Short has quickly won the hearts of users in markets such as Southeast Asia and Japan, becoming a standout platform in the global short drama space.
Bee Short’s Innovative Model
Bee Short is not just a simple viewing platform. Its uniqueness lies in its “Short Drama + Traffic Investment” model, transforming the viewing experience into an opportunity for wealth creation.
Dual Income Streams
Bee Short offers users two primary ways to earn:
1. Sharing Rewards
By running social groups and inviting friends to join Bee Short memberships, users can earn up to 50% in direct referral rewards for every payment made by their referrals. Additionally, secondary referrals provide an extra 10% reward, enabling effortless social-based income.
2. Traffic Investment Rewards
Similar to the short video ads seen on Facebook or TikTok, short drama traffic investment involves promoting dramas to attract more viewers to subscribe to membership services. Users can earn up to 80% of the revenue generated by these transactions.
This low-barrier, high-reward model turns viewing into not only a source of entertainment but also a viable side hustle.
Key Advantages of Bee Short
Bee Short’s rapid global rise is fueled not just by its strong technological foundation but also by its unique platform design and user experience advantages:
1. Multilingual Support
Bee Short spans Southeast Asia, Japan, Korea, Europe, and beyond, offering multilingual support to help users break geographical boundaries and achieve global promotions.
2. Intelligent Traffic Investment System
Using big data analytics and artificial intelligence, Bee Short accurately matches audience preferences, enabling agents to maximize their traffic investment results.
3. Comprehensive Training Support
From traffic investment techniques and social group management to the use of short drama materials, Bee Short provides professional training tutorials and one-stop services, ensuring that every user can get started with ease.
4. Sustainable Income Model
Through its dual-income streams and agent referral mechanism, Bee Short offers users multi-layered income opportunities, from individual traffic investment to team management, creating true “sustainable wealth.”
Short Drama Traffic Investment: The Unmissable New Trend
Short dramas are an emerging force in the short video industry with untapped market potential. According to data projections, the global short drama market is set to exceed $100 billion in the next three years. With cutting-edge technology, abundant resources, and an innovative business model, Bee Short is leading users to seize this golden opportunity.
Join Bee Short: Embrace a New Platform for Entertainment and Wealth
Every emerging trend is a gift for those who are ready to act. Bee Short is providing a platform that combines entertainment and income generation. Register now to become a Bee Short agent and kickstart your journey to financial freedom.
Click here to learn more: https://h5.beeshort.net
Media Contact
Organization: Bee Skits LTD
Contact Person: Cheng Hao
Website: https://beeshort.net
Email: Send Email
City: Hong Kong
Country: China
Release Id: 07012522300
Disclaimer: The information provided in this content is for informational purposes only and does not constitute financial, investment, or business advice. Participation in referral programs and traffic investment involves inherent risks, and results may differ based on individual effort and market conditions. Potential users are encouraged to research and seek professional guidance before engaging in investment or business activities.
The post Bee Short Leading the Global Wave of Short Drama Entertainment and Wealth Creation appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
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