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China Medical System(00867)Obtained Class 1 Innovative Drug Long-acting Anti-IL-4Rα Monoclonal Antibody MG-K10

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SHENZHEN, CHINAChina Medical System Holdings Limited (the “Company”, together with its subsidiaries, the “Group” or “CMS”) is pleased to announce that on 24 January 2025, the Group through subsidiaries of the Company entered into a Collaboration Agreement with Hunan Mabgeek Biotechnology Co., Ltd. (“Mabgeek Biotechnology”) and its subsidiary for Class 1 innovative drug anti-IL-4Rα humanized monoclonal antibody injection MG-K10 (“MG-K10” or the “Product”). The Group has obtained the co-development right as specifically agreed upon in the Agreement and exclusive commercialization right to the Product in Mainland China, Hong Kong Special Administrative Region, Macao Special Administrative Region, Taiwan Region and Singapore (the “Territory”); Mabgeek Biotechnology will support the commercialization activities and is responsible for the sale and supply of the Product. The collaboration term is perpetual.

 

IL-4Rα is considered a key target for the treatment of type 2 inflammatory diseases, such as atopic dermatitis (AD), asthma, prurigo nodularis, etc. Anti-IL-4Rα monoclonal antibodies are among the best-selling biologics in this field. MG-K10 is an innovative long-acting anti-IL-4Rα humanized monoclonal antibody that simultaneously blocks the signaling of key type 2 inflammatory cytokines IL-4 and IL-13. Following Fc mutation, MG-K10 allows long dosing interval owing to its prolonged half-life, and it is expected to be the first long-acting anti-IL-4Rα monoclonal antibody marketed in China. Currently marketed anti-IL-4Rα drugs require dosing every two weeks, whereas MG-K10 only requires dosing every four weeks, demonstrating good efficacy and safety. MG-K10 has the potential to be the Best-in-Class (BIC).

 

This collaboration marks another significant milestone for Dermavon (formerly known as CMS Skinhealth)’s layout in the dermatology field. MG-K10 will enrich the global differentiated innovative pipeline of Dermavon, and will strongly synergize with the existing product portfolio, such as marketed innovative drug ILUMETRI (tildrakizumab injection), marketed exclusive drug Hirudoid (mucopolysaccharide polysulfate cream) and dermatology-grade skincare products of Heling soothing product series (developed for AD patients), and innovative pipeline drugs ruxolitinib cream (for the topical treatment of mild to moderate AD and nonsegmental vitiligo) and povorcitinib (for the treatment of non-segmental vitiligo, hidradenitis suppurativa, prurigo nodularis and chronic spontaneous urticaria), etc. Leveraging its proven clinical development and commercialization capabilities, the Group will fully cooperate with Mabgeek Biotechnology to promote the approval of MG-K10 in China, bringing a new treatment option with lower dosing frequency, good efficacy and safety to patients with type 2 inflammatory diseases in China.

 

More information about MG-K10

MG-K10 is a Class 1 innovative drug anti-IL-4Rα humanized monoclonal antibody injection that used for the treatment of type 2 inflammatory diseases, including AD, asthma, prurigo nodularis, allergic rhinitis, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, chronic obstructive pulmonary disease and so on. It holds substance patents in specific countries/regions within the Territory.

 

MG-K10 has entered Phase III clinical trials in China for AD, asthma, and prurigo nodularis. In the completed Phase II clinical trials for adult moderate-to-severe AD and moderate-to-severe asthma, MG-K10 has demonstrated good efficacy and safety[1-2]. Additionally, MG-K10 has obtained IND approval for eosinophilic esophagitis, chronic rhinosinusitis with nasal polyps, and seasonal allergic rhinitis in China.

 

According to Frost & Sullivan, the global market for treatments targeting IL-4Rα is expected to reach US$28.7 billion by 2030, with a compound annual growth rate (CAGR) of 21.8% from 2020 to 2030. In China, the market is projected to reach US$4.08 billion by 2030, with a CAGR of 76.8% from 2020 to 2030.

 

About AD indication

MG-K10’s first indication, AD, is a chronic inflammatory skin condition characterized by severe itching. It is the most burdensome non-fatal skin disease globally, with at least 230 million people affected worldwide[3]. AD is also a prevalent and high-burden chronic disease in China, with the prevalence showing an upward trend[3]. According to the Global Burden of Disease Study 2019, the number of AD patients in China increased by 25.65% from 1990 to 2019[3]. It is estimated that there are approximately 36.09 million AD patients in China[3], with approximately 9.625 million suffering from moderate-to-severe AD[4].

 

Current treatment options for AD primarily include topical and systemic treatments. For moderate-to-severe AD, topical medications are often insufficient to achieve disease control, necessitating the initiation of systemic treatments. However, due to the limitations in efficacy and safety of traditional systemic therapies for AD, moderate-to-severe AD patients often experience delays in systemic treatment initiation, poor compliance, and suboptimal disease control, leaving a significant unmet need in clinical practice[3]. MG-K10, with its extended dosing interval of once every four weeks, is expected to improve patient adherence and provide a new, effective, and safe systemic treatment option for patients with moderate-to-severe AD.

 

About Mabgeek Biotechnology

Mabgeek Biotechnology was founded in 2016 and has always adhered to the research and development concept of innovation, efficiency and safety, focusing on the fields of allergic inflammatory diseases and autoimmune diseases. Mabgeek Biotechnology is equipped with a research and development team composed of top industry experts. With excellent research capabilities and deep industry experience, Mabgeek Biotechnology uses its unique TEADA high-throughput antibody screening platform to develop innovative antibody drugs with high biological activity, excellent druggability, and differentiation. Mabgeek Biotechnology is committed to providing safer, more effective and more convenient treatment solutions for patients worldwide. For more information about Mabgeek Biotechnology and its products, please visit: https://www.mabge.com/.

 

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

 

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

 

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries. While strengthening the competitiveness of the cardio-cerebrovascular/gastroenterology business, CMS independently operates its dermatology and medical aesthetics business, and ophthalmology business, aiming to gain leading positions in specialty therapeutic fields, whilst enhancing the scale and efficiency. At the same time, CMS has expanded its business territory to the Southeast Asian market, striving to become a “bridgehead” for global pharmaceutical companies to enter the Southeast Asian market, further escorting the sustainable and healthy development of the Group.

 

Reference:

  1. The data of the product’s Phase II clinical trial for AD indication as disclosed by Mabgeek: https://www.mabge.com/en/index.php?c=show&id=23
  2. The interim data of the product’s Phase II clinical trial for asthma indication as disclosed by Mabgeek: https://www.mabge.com/index.php?c=show&id=18
  3. Chinese Society of Dermatology, China Dermatologist Association. Clinical pathway for the diagnosis and treatment of moderate to severe atopic dermatitis in China (2023): an expert consensus[J]. Chinese Journal of Dermatology, 2023, 56(11): 1000-1007. DOI: 10.35541/cjd.20230247.
  4. Mao, Dandan et al. Prevalence and risk factors of atopic dermatitis in Chinese adults: a nationwide population-based cross-sectional study. Chinese medical journal vol. 136,5 604-606. 5 Mar. 2023, DOI:10.1097/CM9.0000000000002560

 

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

 

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

 

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

Source: China Medical System Holdings Ltd.

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Eagle Crest Asset Management: Pioneering Financial Innovation and Global Investment Excellence Introduction

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Eagle Crest Asset Management: Pioneering Financial Innovation and Global Investment ExcellenceIntroduction

Denver, United States, 26th Jan 2025 – Founded in 2019 by Ridel Bosco Castillo and his visionary partners, Eagle Crest Asset Management stands as a beacon of financial expertise and innovation. Built on the pillars of professionalism, education, and customer-centric service, the firm is dedicated to enhancing investment efficiency through cutting-edge practices, advanced risk management strategies, and the integration of groundbreaking technologies like big data, artificial intelligence (AI), and blockchain.

As the global financial landscape becomes increasingly dynamic, Eagle Crest Asset Management leverages its robust foundation to navigate complexities and unlock opportunities, particularly in emerging markets. With a diverse range of investment options spanning stocks, funds, foreign exchange, bonds, options, gold, and cryptocurrencies, the firm ensures that clients receive comprehensive solutions tailored to their unique financial goals. A hallmark of its services is the proprietary Eagle Eye Advanced Quantitative Investment System, which empowers clients with data-driven insights to make informed decisions.

Vision and Mission

At the heart of Eagle Crest Asset Management is a clear mission: to revolutionize the investment industry by integrating technology and innovation into every aspect of financial management. The firm’s vision is to create a future where financial independence is accessible to all through reliable, transparent, and efficient asset management.

Eagle Crest emphasizes education as a core component of its operations, ensuring clients and partners are equipped with the knowledge needed to thrive in an ever-evolving market. This commitment to education fosters trust and empowers stakeholders to actively participate in their financial journeys.

Strategic Focus on Emerging Markets

Emerging markets are a cornerstone of Eagle Crest’s investment strategy. These regions, characterized by rapid economic growth and expanding consumer bases, present unparalleled opportunities for investors. The firm’s deep understanding of these markets allows it to identify and capitalize on future trends, ensuring long-term value creation for its clients.

Eagle Crest employs a rigorous approach to analyzing emerging markets, incorporating macroeconomic data, political stability indices, and sector-specific trends. This holistic perspective ensures that investments are both strategic and sustainable, aligning with the firm’s commitment to responsible asset management.

Diversified Investment Solutions

Eagle Crest offers a comprehensive suite of investment solutions designed to cater to the diverse needs of its clientele. By maintaining a diversified portfolio, the firm mitigates risks while maximizing returns. Below is an overview of the key asset classes managed by the firm:

Stocks and Funds: Leveraging advanced analytics and market expertise, Eagle Crest identifies high-potential equities and mutual funds. Clients benefit from personalized strategies that align with their risk tolerance and financial objectives.

Foreign Exchange (Forex): The firm’s Forex services provide clients with access to one of the largest and most liquid markets in the world. Eagle Crest’s experts utilize sophisticated trading algorithms to optimize currency trading strategies.

Bonds and Options: Eagle Crest’s fixed-income solutions are designed to deliver stability and consistent returns. Additionally, its options trading strategies offer clients the flexibility to hedge risks or speculate on market movements effectively.

Gold and Precious Metals: Recognizing the enduring value of gold and other precious metals, Eagle Crest incorporates these assets into its portfolios as a hedge against inflation and economic uncertainty.

Cryptocurrency: With the rise of blockchain technology and digital assets, Eagle Crest is at the forefront of cryptocurrency investments. The firm’s expertise in this domain ensures clients can navigate this volatile yet promising asset class with confidence.

Technological Innovation: The Eagle Eye Advanced Quantitative Investment System

A defining feature of Eagle Crest Asset Management is its proprietary Eagle Eye Advanced Quantitative Investment System. This state-of-the-art platform integrates big data analytics, AI, and machine learning to provide clients with real-time insights and predictive models. By analyzing vast datasets and identifying patterns, the system enhances decision-making and minimizes risks.

The Eagle Eye system is particularly effective in managing complex portfolios, offering capabilities such as:

Predictive analytics for market trends.

Automated risk assessment and mitigation.

Real-time performance monitoring and optimization.

Through this technology-driven approach, Eagle Crest ensures that clients are always a step ahead in their investment journeys.

Building a Global Reserve Fund

In its pursuit of financial innovation and resilience, Eagle Crest is establishing a groundbreaking global reserve fund. This fund will encompass a diverse range of assets, including global stocks, commodities, gold, and cryptocurrencies. The objective is to create a robust financial buffer that safeguards against market volatility while delivering sustainable growth.

The global reserve fund will be managed using Eagle Crest’s advanced technological tools and investment expertise. By adopting a multi-asset strategy, the fund aims to achieve optimal diversification and risk-adjusted returns. Key highlights of the fund include:

Asset Allocation: A balanced mix of traditional and alternative assets to ensure stability and growth.

Risk Management: Advanced quantitative models to assess and mitigate risks in real time.

Global Reach: Investments spanning multiple geographies and sectors to capitalize on global opportunities.

Sustainability: Incorporating environmental, social, and governance (ESG) criteria to align with ethical investment practices.

Commitment to Education and Client Service

Eagle Crest Asset Management’s dedication to education sets it apart in the financial industry. The firm regularly conducts workshops, seminars, and webinars to keep clients informed about market trends, investment strategies, and technological advancements. By fostering a culture of transparency and knowledge sharing, Eagle Crest empowers clients to make confident financial decisions.

Customer service is another cornerstone of the firm’s operations. Eagle Crest’s team of seasoned professionals is committed to providing personalized support, ensuring that clients receive timely and accurate assistance. The firm’s client-centric approach builds long-term relationships based on trust and mutual success.

The Road Ahead

As Eagle Crest Asset Management looks to the future, it remains steadfast in its mission to redefine the investment landscape. By leveraging its technological expertise, strategic insights, and commitment to education, the firm is well-positioned to navigate the challenges and opportunities of a rapidly evolving financial world.

The establishment of the global reserve fund marks a significant milestone in Eagle Crest’s journey. This initiative not only strengthens the firm’s capabilities but also reinforces its commitment to delivering unparalleled value to its clients. As the firm continues to expand its global footprint, it remains guided by its core values of innovation, integrity, and excellence.

Conclusion

Eagle Crest Asset Management has emerged as a leader in the financial services industry by combining traditional investment principles with cutting-edge technologies. Under the visionary leadership of Ridel Bosco Castillo and his team, the firm has consistently delivered exceptional results, earning the trust and loyalty of clients worldwide.

With a focus on emerging markets, diversified investment solutions, and a commitment to education, Eagle Crest is shaping the future of asset management. The launch of the global reserve fund underscores the firm’s dedication to innovation and resilience, paving the way for sustained success in an increasingly complex financial landscape.

As Eagle Crest continues to push boundaries and set new standards, it invites investors to join its journey toward financial empowerment and global investment excellence.

 

Banking & Professional Services - ISS World

 

Media Contact

Organization: HB Wealth Advisors

Contact Person: Emily Brown

Website: https://hbwealthadvisors.com/

Email: Send Email

Address: 789 Summit Boulevard Suite 101 Denver

State: 789 Summit Boulevard Suite 101 Denver

Country: United States

Release Id: 26012522993

The post Eagle Crest Asset Management: Pioneering Financial Innovation and Global Investment Excellence Introduction appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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Summitt Partners Capital LTDA to Launch Revolutionary AI Investment System in Q1

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Brazil, 26th Jan 2025 – Summitt Partners Capital LTDA, a renowned investment firm helmed by founder and CEO Michael Harrison, has announced its plan to launch a groundbreaking AI-driven investment system. This innovative platform, poised to redefine the future of asset management and investment strategies, is slated for release in the first quarter of 2025. With this ambitious development, Summitt Partners Capital reaffirms its dedication to delivering cutting-edge financial solutions to its clients.

A Leap Forward in Investment Technology

The forthcoming AI system represents a culmination of extensive research and development by Summitt’s team of financial experts, data scientists, and technologists. By leveraging the latest advancements in artificial intelligence and machine learning, the system is designed to optimize investment strategies, identify high-yield opportunities, and mitigate risks with unprecedented precision.

Michael Harrison, CEO of Summitt Partners Capital, expressed his excitement about the project, stating, “Our new AI investment system is not just a tool but a revolution in how we approach the financial markets. By combining our expertise with state-of-the-art technology, we aim to empower our clients with smarter, faster, and more accurate investment decisions.”

Key Features of the AI Investment System

The AI-driven investment platform boasts several groundbreaking features:

Advanced Predictive Analytics: Utilizing real-time market data and historical trends, the system can predict market movements with remarkable accuracy, enabling proactive investment strategies.

Dynamic Risk Management: The AI employs sophisticated algorithms to analyze risk factors continuously and adjust portfolios accordingly, safeguarding investments against volatile market conditions.

Customized Investment Solutions: By assessing individual client profiles, the platform generates personalized strategies tailored to specific financial goals, risk tolerance, and investment horizons.

24/7 Market Monitoring: Unlike traditional methods, the system operates around the clock, ensuring clients never miss critical market opportunities.

Seamless Integration: Designed for compatibility with existing financial systems, the platform facilitates smooth transitions for institutional and individual investors alike.

What is Paid Up Capital? Definition, Advantages, and Ways to Increase

A Commitment to Client Empowerment

At the heart of this development lies Summitt’s unwavering commitment to client success. The AI system is designed to democratize access to advanced investment tools, making sophisticated strategies available not only to large institutions but also to individual investors.

“Our mission is to break down barriers in the financial world,” Harrison emphasized. “This platform ensures that every client, regardless of their portfolio size, has access to world-class investment solutions.”

Strategic Partnerships and Collaborations

Summitt Partners Capital has collaborated with leading technology firms and academic institutions to bring this vision to life. By combining proprietary financial models with cutting-edge AI technologies, the firm has ensured that the system is both robust and innovative.

The development process also included extensive beta testing with select clients and industry experts, whose feedback was instrumental in fine-tuning the system’s functionalities. Early adopters have praised the platform’s intuitive interface, speed, and accuracy in delivering actionable insights.

Implications for the Global Financial Market

The launch of this AI investment system comes at a pivotal time for the financial industry. With markets becoming increasingly complex and volatile, there is a growing demand for tools that can navigate these challenges effectively. Summitt’s innovation is expected to set a new benchmark for the industry.

According to a recent report by the World Economic Forum, AI-driven tools are projected to manage over $10 trillion in assets by 2030. By entering this space now, Summitt Partners Capital positions itself as a leader in the next wave of financial innovation.

Addressing Concerns Around AI in Finance

While the benefits of AI in investment are undeniable, concerns about transparency, ethical considerations, and data security remain. Summitt Partners Capital has proactively addressed these issues by incorporating robust safeguards into the system. The platform adheres to stringent regulatory standards and employs advanced encryption methods to protect client data.

Additionally, the firm has established an Ethics Advisory Board to oversee the AI’s decision-making processes, ensuring they align with Summitt’s values of integrity and client-first service.

Training and Support for Clients

To maximize the platform’s potential, Summitt Partners Capital is rolling out a comprehensive client support program. This includes:

Workshops and Webinars: Regular sessions to educate clients on leveraging the system’s features effectively.

Dedicated Support Teams: A team of specialists available 24/7 to assist with any technical or strategic queries.

User-Friendly Documentation: Step-by-step guides and video tutorials designed to simplify the onboarding process.

“Education is key to empowering our clients,” noted Harrison. “We want them to feel confident in using this technology to achieve their financial goals.”

Looking Ahead: The Future of Summitt Partners Capital

The launch of the AI investment system is just one of many initiatives in Summitt Partners Capital’s ambitious roadmap. The firm is committed to continuous innovation, with plans to expand its AI capabilities to other areas such as sustainable investments and global market analytics.

“This is just the beginning,” Harrison said. “As technology evolves, so will our solutions. Our goal is to stay ahead of the curve and consistently deliver value to our clients.”

About Summitt Partners Capital LTDA

Founded by Michael Harrison, Summitt Partners Capital LTDA is a distinguished investment firm based in São Paulo, Brazil. The company specializes in asset management, strategic investments, and delivering innovative financial solutions. With a client-centric approach and a commitment to excellence, Summitt Partners Capital has established itself as a trusted partner in the global financial market.

Conclusion

The upcoming launch of Summitt’s AI-driven investment system marks a significant milestone for the firm and the financial industry at large. By harnessing the power of artificial intelligence, Summitt Partners Capital is not only enhancing its service offerings but also paving the way for a smarter, more efficient future in finance.

For more information about the AI investment system and other initiatives, visit Summitt Partners Capital LTDA’s website or contact their dedicated support team.

Media Contact

Organization: SUMMITT CAPITAL

Contact Person: Michael Harrison

Website: https://www.sfpll.com

Email: Send Email

Country: Brazil

Release Id: 26012522995

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Radical Marketing Redefines Strategies for Coaching Businesses with Proven Solutions

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Kota Kinabalu, Sabah, Malaysia, 26th Jan 2025 – Radical Marketing, a leader in digital marketing innovation, is revolutionizing the way coaching businesses attract and retain clients. Through tailored solutions such as marketing for coaching businesses and expertly designed webinar funnels by Radical Marketing, the company empowers coaches to achieve measurable growth and long-term success.

 

The coaching industry is highly competitive, requiring coaches to go beyond expertise in their field and master the art of connecting with their audience. Radical Marketing provides a comprehensive approach to marketing for coaching businesses by Radical Marketing, including brand positioning, lead generation, and customized campaigns. These strategies are specifically designed to help coaches optimize resources and achieve maximum impact.

Webinars have become indispensable tools for engaging potential clients and showcasing expertise. A webinar funnel by Radical Marketing offers an end-to-end solution, guiding participants from registration to conversion. With a focus on high-value content and actionable calls-to-action, these funnels ensure that coaches can effectively convert leads into loyal clients. Radical Marketing’s proven approach to webinar funnels ensures every stage is optimized for engagement and results.

In today’s digital-first landscape, establishing a robust online presence is essential. Radical Marketing offers digital marketing for coaches that combines innovative strategies with practical implementation. Through search engine optimization (SEO), email marketing, and social media campaigns, coaching businesses can amplify their visibility and influence. To explore actionable strategies further, this guide offers insights on engaging audiences, building trust, and driving client engagement. Coaches can leverage these techniques to stand out in a crowded marketplace and foster lasting relationships with their clients.

A professional and cohesive online presence is vital for success in the coaching industry. Radical Marketing specializes in creating and maintaining websites, social media platforms, and other digital assets that reflect a coach’s unique value proposition. These efforts ensure that coaching businesses connect effectively with their target audiences. Content marketing is a cornerstone of successful digital strategies. Radical Marketing’s expertise in crafting engaging blog posts, videos, and eBooks helps coaches position themselves as thought leaders. By integrating these assets into a webinar funnel by Radical Marketing, coaches can guide potential clients through the decision-making process and convert them into loyal customers.

About Radical Marketing

Radical Marketing is a premier digital marketing agency specializing in services for coaching businesses. From marketing for coaching businesses to advanced digital strategies, Radical Marketing provides tailored solutions that drive measurable results. For more information, visit Radical Marketing.

 

Media Contact

Organization: Radical Marketing

Contact Person: Terence Tam

Website: https://www.radical-marketing.com/

Email: terry@radical-marketing.com

Contact Number: +601111315687

Address: Unit 1-8, Wisma Damai Point Jalan Damai Point Luyang Commercial Centre Kota Kinabalu, Sabah

City: Kota Kinabalu

State: Sabah

Country: Malaysia

Release Id: 26012522918

The post Radical Marketing Redefines Strategies for Coaching Businesses with Proven Solutions appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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