Press Release
China Medical System: Innovative Drug Methylthioninium Chloride Enteric-coated Sustained-release Tablets Approved for Marketing in China
- Innovative drug Methylthioninium Chloride Enteric-coated Sustained-release Tablets (Lumeblue®) is an oral diagnostic drug, approved by China’s NMPA for enhancing visualisation of colorectal lesions in adult patients undergoing screening or surveillance colonoscopy.
- The results of the Phase III clinical trial in China show that the Product can significantly improve the detection rate of non-polypoid colorectal lesions (the primary endpoint of the study), leading to an improved detection rate of dangerous lesions such as non-polypoid adenomas (the secondary endpoint).
- The Product can be taken during the bowel preparation step, ensuring that colorectal staining is completed by the time colonoscopy is conducted. This not only enhances the detection rate of colorectal lesions but also potentially simplifies the colonoscopy procedure, making the examination more efficient and improving the screening benefits.
- As of now, CMS’s newly launched innovative portfolio has been expanded to 5 products, continuously generating driving force to the Group’s sustainable and healthy development.
SHENZHEN, CHINA – China Medical System Holdings Limited (the “Company”, together with its subsidiaries, the “Group” or “CMS”) is pleased to announce that on 11 June 2024, the New Drug Application (NDA) of the Group’s innovative drug methylthioninium chloride enteric-coated sustained-release tablets (Lumeblue®) (the “Product”) has been approved by the National Medical Products Administration of China (NMPA). The drug registration certificate was obtained on 18 June 2024. The Product is indicated to enhancing visualisation of colorectal lesions in adult patients undergoing screening or surveillance colonoscopy, and it is the first oral methylthioninium chloride enteric-coated sustained-release tablets in China. The Group will synergize with existing gastroenterology products and resources to advance the commercialization and academic promotion related works of the Product in an orderly manner, aiming to achieve nationwide large-scale clinical application as soon as possible so as to benefit patients with colorectal disease.
Lumeblue® is an oral diagnostic drug that uses patented multi-matrix (MMX) technology to deliver active substances directly to the colon and release them locally in a controlled manner. As an enhancer dye, the Product increases the contrast between colorectal lesions and healthy mucosa. The results of the Phase III clinical trial in China show that the Product can significantly improve the detection rate of non-polypoid colorectal lesions(the primary endpoint of the study), leading to an improved detection rate of dangerous lesions such as non-polypoid adenomas (the secondary endpoint)[1]. In addition, the Product can be taken during the bowel preparation step, ensuring that colorectal staining is completed by the time colonoscopy is conducted. This not only enhances the detection rate of colorectal lesions but also potentially simplifies the colonoscopy procedure, making the examination more efficient and improving the screening benefits.
According to the diagnosis and treatment data of the Digestive Endoscopy Branch of the Chinese Medical Association, approximately a total of 28 million gastroenteroscopies were completed nationwide in 2012, including 5.83 million colonoscopies. In 2019, approximately 38.73 million gastroenteroscopies were completed nationwide, an increase of 34.62% compared with 2012[2]. The Chinese consensus of early colorectal cancer screening recommends that people aged 50 to 75 years old should be screened for colorectal cancer regardless of whether they have alarm symptoms[3]. There are approximately 400 million people aged 50 to 75 in China in 2020[4]. With the popularity of early screening for colorectal cancer in China, it is expected to witness a considerable growth of the number of colonoscopies in China in the future.
The Product has been approved by the European Medicines Agency (EMA) to be commercialized in the European Union under the trade name Lumeblue
in August 2020. The Group obtained an exclusive license for the Product from Cosmo Technologies Ltd, a fully owned subsidiary of Cosmo Pharmaceuticals NV, on 3 December 2020.
Driven by the twin-wheel of “Collaborative R&D and Independent R&D”, CMS has continuously deployed global first-in-class (FIC) and best-in-class (BIC) innovative products guided by patient and clinical demands. With enhancing R&D capabilities in developing differentiated innovative products, CMS has empowered the continuous transformation of scientific research outcomes into clinical application, continuously releasing the value of innovation. As of now, CMS’s newly launched innovative portfolio has been expanded to 5 products, continuously generating driving force to the Group’s sustainable and healthy development. Desidustat Tablets and Methotrexate Injection (rheumatoid arthritis), CMS’s innovative pipeline products, are currently under NDA review in China. Meanwhile, over 10 innovative pipeline products are undergoing clinical trials in China, mainly randomized controlled trials (RCT). CMS is expected to launch differentiated innovative products every year in the future with higher efficiency and more controllable costs, continuing to optimize its product portfolio and build fresh driving forces for the mid- to long-term development of the Company.
About CMS
CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.
CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.
CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries. While strengthening the competitiveness of the cardio-cerebrovascular/gastroenterology business, CMS independently operates its dermatology and medical aesthetics business, and ophthalmology business, aiming to gain leading positions in specialty therapeutic fields, whilst enhancing the scale and efficiency. At the same time, CMS has expanded its business territory to the Southeast Asian market, striving to become a “bridgehead” for global pharmaceutical companies to enter the Southeast Asian market, further escorting the sustainable and healthy development of the Group.
Reference:
- The results of the Phase III clinical trial in China was published and can be found at: https://web.cms.net.cn/en/2022/12/positive-results-for-china-phase-iii-clinical-trial-of-methylthioninium-chloride-enteric-coated-sustained-release-tablets/
- The diagnosis and treatment data of the Digestive Endoscopy Branch of the Chinese Medical Association
- Chinese consensus of early colorectal cancer screening (2019, Shanghai)，Chinese Journal of Internal Medicine，DOI： 10.3760/cma.j.issn.0578-1426.2019.10.004
- CHINA POPULATION CENSUS YEARBOOK 2020, can be found at： https://www.stats.gov.cn/sj/pcsj/rkpc/7rp/zk/indexch.htm
CMS Disclaimer and Forward-Looking Statements
This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.
This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.
Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Email: ir@cms.net.cn
Website: https://web.cms.net.cn/en/home/
Source: China Medical System Holdings Ltd.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Promotional Product Experts: One-Stop Destination for High-Quality Branded Business Products Across Australia
Australia, 25th Nov 2024 – Promotional Product Experts, a leading provider of custom-branded business promotional products, is redefining how companies across Australia promote their brands. Offering a diverse range of items with professional printing and embroidery services, the company ensures businesses can create impactful and cost-effective promotional campaigns.
Whether you’re looking for a simple ballpoint pen or a large golf umbrella, Promotional Product Experts guarantees value, quality, and precision across all items. The company also offers a wide variety of branded corporate promotional materials, including keyrings, clothing and apparel, coffee mugs, bags, satchels, and more. Businesses in major cities such as Brisbane, Melbourne, Sydney, Perth, and Adelaide can benefit from these top-tier services.
A Seamless Experience for Your Brand’s Promotional Needs
Promotional Product Experts understands the importance of delivering exceptional service. The website is designed for ease of use, allowing customers to browse a comprehensive catalog of products and request quotes effortlessly. The team provides accurate artwork specifications tailored to individual items, ensuring the final product exceeds expectations.
“We pride ourselves on providing not only high-quality promotional products but also a seamless and efficient experience for our clients,” said Gavin Sekler, spokesperson for Promotional Product Experts. “From concept to delivery, we’re committed to proactive customer service and timely delivery for complete peace of mind.”
Innovative Product Offerings for Every Need
The company specializes in a variety of promotional products, including:
- Corporate Cheese Sets: Add a touch of sophistication to your branding with promotional cheese boards. Explore options at Corporate Cheese Sets.
- Corporate Umbrellas: Make a lasting impression with high-quality branded umbrellas. Learn more at Corporate Umbrellas.
These products are carefully curated to enhance a brand’s visibility while maintaining a professional image.
Reliable Delivery and Expert Support
Promotional Product Experts is committed to delivering a hassle-free experience. With a proactive customer support team just a phone call away, the company ensures businesses can navigate the entire process smoothly. Whether it’s addressing queries or assisting with artwork, the team is dedicated to providing unparalleled support.
Why Choose Promotional Product Experts?
- High-quality corporate promotional merchandise.
- Affordable and effective branding solutions for businesses.
- Proactive customer service and reliable delivery across Australia.
- Easy-to-navigate website for convenient browsing and quoting.
Businesses seeking impactful promotional products can trust Promotional Product Experts to deliver excellence at every step.
Get Started Today
Join the many Australian companies that have enhanced their brand visibility with Promotional Product Experts. Visit www.promotionalproductexperts.com.au to explore the range of promotional business products and request your quote today.
About Promotional Product Experts
Promotional Product Experts is a trusted provider of high-quality promotional merchandise, specializing in professionally branded business items to meet the marketing needs of companies across Australia. With years of experience in the industry, the company has established itself as a leader by offering a diverse range of products combined with exceptional customer service. Whether for corporate events, employee giveaways, or marketing campaigns, Promotional Product Experts delivers innovative solutions that leave a lasting impression.
Media Contact
Organization: Promotional Product Experts
Contact Person: Gavin Sekler
Website: https://www.promotionalproductexperts.com.au/
Email: Send Email
Country: Australia
Release Id: 25112420419
The post Promotional Product Experts: One-Stop Destination for High-Quality Branded Business Products Across Australia appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Last year, Paradigm’s CTO Georgios Konstantopoulos pointed out the inefficiencies in how crypto chains and assets work together via one of his tweets. His thoughts highlighted a major issue in Web3 adoption: complexity.
This native model has become a big hurdle in mass adoption of web3. Even completing one single transaction at times requires too many complex steps Just to make a transaction on a new Layer 1 or Layer 2, a user needs to create an account, securely store the private key or seed phrase, buy gas tokens via a centralized exchange, or bridge assets from another chain-just to start interacting with the new ecosystem.
This process can overwhelm traditional users used to simple “plug-and-play”systems. Thankfully, Web3 builders are introducing “execution-free” solutions to make onboarding easier.
DuckChain: Bridging Web2 and Web3 with ISO
DuckChain is leading the way of this evolution. As the first consumer-grade Layer solution on The Open Network (TON), DuckChain introduced the innovative concept of ISO (Initial Star Offering). This allows users to convert Telegram Stars into on-chain Star assets, bridging Web2 and Web3 seamlessly.
This unique feature makes DuckChain the key to onboarding millions of Telegram users into Web3. It also connects TON with EVM and Bitcoin ecosystems, boosting liquidity and bringing developers to TON.
The market has also recognized DuckChain’s narrative and growth potential.
DuckChain’s Testnet Achievements
DuckChain’s testnet was a massive success:
- Daily Active Users: Over 2 Million on MiniApps
- Total Transactions: 29 million
- User Deposits: $2 million from Web2 users
- Paying Users: 1 Million
- Partners: Supported by 20+ partners like Arbitrum and OKX
With the mainnet launch, DuckChain is all set to accelerate Telegram’s evolution into a super app and open a portal connecting the Web2 and Web3 worlds.
ISO: Introducing Telegram Stars as Unified Gas for Chain Transactions
DuckChain, the first TON-based Layer solution built on Arbitrum Orbit, positions itself as a consumer layer. Its mission is to onboard nearly a billion Telegram users to blockchain infrastructure.
Today, most blockchains use their native tokens as gas fees which means users need different tokens for various ecosystems, which makes cross-chain transactions complicated. DuckChain solves this by creating a unified gas system through ISO (Initial Star Offering). With ISO, Telegram Stars can easily be turned into on-chain assets to pay gas fees.
DuckChain’s new mainnet supports assets for on-chain activities. Future updates will also add features like account and chain abstraction to make transactions even easier.
Telegram Star, the native token for the Telegram ecosystem, simplifies payments for services and goods. It can be purchased directly with Apple Pay or Google Pay without needing third-party platforms. Both Web2 and Web3 users can use Telegram Stars within DuckChain, making transactions simple and accessible.
This system not only connects Web2 and Web3 users but also opens doors for wider use of decentralized finance (DeFi) within Telegram’s ecosystem.
DuckChain: Enabling Telegram’s Super App Ambitions
Telegram has integrated with TON and launched MiniApps, aiming to become a Web3 super app.
However, building a mature Web3 ecosystem requires three essentials: user traffic, liquidity, and a thriving ecosystem.
Currently, the Telegram ecosystem faces 3 key challenges:
- A predominantly off-chain user base of nearly 1 billion.
- A TVL of $300M concentrated in TON and stablecoins, indicating liquidity shortages.
- Complex development frameworks which slows developer participation.
DuckChain addresses these challenges through ISO, liquidity hubs, and modular development tools.
TON’s Liquidity Hub
EVM-compatible chains currently hold 80% of the total $100 billion in DeFi, while Bitcoin assets represent a large, untapped $1.8 trillion market. TON’s ecosystem, however, faces liquidity shortages. DuckChain, built on Arbitrum Orbit, connects TON with EVM-compatible ecosystems for seamless interoperability.
Moreover, it integrates deeply with Bitcoin L2 solutions, such as Babylon, making it a crucial bridge for TON’s liquidity and value exchange.
DuckChain’s mainnet introduces solutions like multi-chain and liquidity abstraction, enabling users to pay gas fees using various tokens, including TON and Telegram Star. It also incentivizes TON staking through DuckChain, offering annual yields and facilitating liquidity flow between ecosystems.
Modular Tools for Developers
To overcome TON’s development complexity, DuckChain collaborates with Arbitrum to provide an EVM-compatible framework, simplifying the creation, deployment, and migration of applications. Developers can leverage staking, marketplaces, DID systems, and other modular tools to build scalable dApps, seamlessly integrated with Telegram MiniApps.
DuckChain has already attracted over 50 ecosystem projects, fueling early-stage growth in TON’s application layer.
Soda Lee
SOURCE: DuckChain
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Dark Academia Fashion – The Ultimate Online Destination for Fashion, Aesthetic and Clothes
Dark Academia Fashion offers quality products for those who cherish classic style and the beauty of Dark Academia.
New York, New York, United States, 25th Nov 2024 – Introducing Dark Academia Fashion, a new online store crafted for lovers of Dark Academia Aesthetic. This carefully curated selection of clothing, accessories, and decor allows visitors to step into a world of intellectual charm and classic elegance, inspired by ivy-clad campuses, timeless literature, and scholarly sophistication.
Dark Academia fashion is more than just a look—it’s an aesthetic that reflects a love for knowledge, art, and classic style. At our Fashion Shop, discover wool blazers, cozy sweaters, pleated skirts, and accessories like leather-bound notebooks and vintage-inspired jewelry, each evoking the moody allure of academia.
What’s on Offer?
Our shop offers a variety of products carefully tailored to each aspect of the Dark Academia aesthetic, including:
Clothing: From tweed blazers and high-waisted trousers to cozy wool sweaters and pleated skirts, our clothing line combines classic cuts with vintage-inspired designs. Each item is crafted to fit seamlessly into the wardrobe of anyone who appreciates understated elegance and academic style.
Accessories: The right accessories can elevate any look, and we offer a range of items designed to complement the Dark Academia wardrobe. Think vintage brooches, leather-bound notebooks, tortoiseshell glasses, and more to complete your look.
Home Decor: A true Dark Academia aesthetic is incomplete without a space that reflects the same mystery and intellectual charm. Our decor selection includes antique-style bookends, brass candle holders, and framed artwork inspired by classic literature and Renaissance art—perfect for creating an atmosphere reminiscent of a time gone by.
To celebrate the launch, Dark Academia Fashion is hosting a virtual event featuring live styling sessions, exclusive product previews, and special giveaways. Register for free on our website and follow us on social media for updates.
Media Contact
Organization: Dark Academia Fashion
Contact Person: Customer Support
Website: https://darkacademiafashion.com
Email: Send Email
Address: 815 Liberty Ave
City: New York
State: New York
Country: United States
Release Id: 25112420415
The post Dark Academia Fashion – The Ultimate Online Destination for Fashion, Aesthetic and Clothes appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
DuckChain Mainnet Launch: Bridging Web2 and Web3 with ISO Innovation
Promotional Product Experts: One-Stop Destination for High-Quality Branded Business Products Across Australia
Dark Academia Fashion – The Ultimate Online Destination for Fashion, Aesthetic and Clothes
Absolutely Princess: A New Children’s Classic by Mayra L Santana Warms Hearts Post Launch
Unusual Machines CEO Discusses Growth and Strategic Plans Post-IPO
Benzinga Money Article Discusses How to Become Part of the 12% of Retirees Who Have Achieved the Recommended $550,000 Minimum Retirement Savings Threshold
-
Press Release3 days ago
A Omega Fencing Company Launches New Eco-Friendly Fencing Options for Environmentally Conscious Homeowners
-
Press Release5 days ago
The Strategy for Avoiding Failures for High Performers with Leila Entezam’s ‘SET UP’ Method
-
Press Release1 week ago
Eagle Crest Asset Management Prepares for Global Investors Summit Founder Ridel Bosco Castillo to Speak on U.S. Investment Landscape and Strategic Collaborations
-
Press Release4 days ago
Humera Tamboli elevates sustainable fashion with purpose: Embracing Supima cotton and Beechwood to create skin friendly capsule clothing
-
Press Release1 week ago
Safe Responsible Movers Earns Silver Medal in Banker & Tradesman’s Best Movers Poll for 2024
-
Press Release7 days ago
Revolutionizing Multilingual Tax and Bookkeeping Services for Global E-commerce Expansion: Flatfee Partners with cc:Monet
-
Press Release1 week ago
Cosmic Network Launches Revolutionary Decentralized Privacy Ecosystem, Addressing Global Digital Freedom Challenges
-
Press Release1 week ago
Zhuding International Limited Signs Reverse Merger Agreement with Automated Water Solutions Inc. and Belisarian Holdings