Press Release
New Clinical Data Reveals MAIA Biotechnology’s THIO Achieves High Efficacy In Advanced Non-Small Cell Lung Cancer Treatment
–News Direct–
By Mangeet Kaur Bouns

Lung cancer remains the top cause of cancer-related deaths in the U.S., accounting for approximately 20% of all cancer fatalities. The American Cancer Society's projections for 2024 highlight the gravity of this issue, with an estimated 234,580 new lung cancer cases and about 125,070 deaths anticipated in the U.S. Of these, nearly 80% to 85% are non-small cell lung cancer (NSCLC) cases, highlighting the urgent need for effective treatments.
MAIA Biotechnology, Inc. (AMEX: MAIA), a clinical-stage biopharmaceutical company focused on developing telomere-targeting immunotherapies for cancer treatment, has unveiled promising new clinical data showcasing the efficacy of its lead product candidate, THIO, in treating NSCLC. This data emerges from a phase 2 clinical trial evaluating THIO in combination with the immune checkpoint inhibitor (CPI) cemiplimab (Libtayo), targeting patients with advanced NSCLC who have not responded to at least two standard-of-care therapies.
In the context of NSCLC, where traditional treatments often fall short, THIO's potential as a first-in-class telomere-targeting agent raises hope. Its ability to disrupt cancer cell telomeres and stimulate immune responses marks a significant advancement in the fight against this devastating disease.
MAIAs Lead Candidate: THIO
THIO is a groundbreaking telomere-targeting agent, currently undergoing phase 2 clinical trials aimed at treating NSCLC with telomerase-positive cancer cells. Telomerase, present in over 85% of human cancers, plays a crucial role in the immortality and proliferation of cancer cells. THIO integrates into telomeres within these cells, disrupting their structure and function leading to rapid tumor cell death.
By inducing telomerase-dependent DNA modification and damage, THIO triggers selective cancer cell death. This process accumulates telomeric damage in cytosolic micronuclei, which then activates both innate (cGAS/STING) and adaptive (T-cell) immune responses. In in vivo cancer models, sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in significant and sustained tumor regression, fostering cancer-specific immune memory.
Key Findings From The Phase 2 THIO-101 Clinical Trial
The phase 2 THIO-101 trial primarily focuses on assessing the safety and tolerability of THIO both as an anticancer agent and as an immune system activator, alongside evaluating its clinical efficacy through overall response rate (ORR).
The trial results are noteworthy. The disease control rate (DCR) for THIO in combination with CPI was 85%, far exceeding the 25-35% DCR typically seen with chemotherapy in third-line treatments. Additionally, 65% of patients surpassed the 5.8-month overall survival (OS) threshold, and 85% exceeded the 2.5-month progression-free survival (PFS) threshold, demonstrating significant clinical benefits. The median survival follow-up time stood at 9.1 months for the cohort of 20 patients.
Optimal dose selection yielded even more impressive outcomes. Patients in third-line receiving 180mg of THIO exhibited a median PFS of 5.5 months, a 75% OS rate at six months and an ORR of 38%, compared to the standard 6-10% ORR for chemotherapy. Notably, 75% of these patients crossed the 5.8-month OS threshold and 88% surpassed the 2.5-month PFS threshold, with a median survival follow-up time of 9.1 months among the eight patients assessed.
Implications And Future Directions
Dr. Vlad Vitoc, chairman and CEO of MAIA, expressed enthusiasm about the trial outcomes, noting, "All exceptional measures of efficacy in our trial to date have exceeded our own expectations and outperformed standard-of-care treatments." He emphasized THIOs potential as a robust, safe and highly effective alternative for patients who have not benefited from chemotherapy and other treatments.
The THIO-101 trial, which completed enrollment ahead of schedule in February, reached its target of 41 patients for the 180 mg dose. This data, which indicates promising disease control and overall response rates, paves the way for further investigation and potential redefinition of cancer treatment protocols.
As THIO-101 data continues to demonstrate favorable disease control and response rates, with full efficacy data anticipated in the latter half of this year, MAIA Biotechnology stands poised to redefine cancer treatment. THIOs promise to transform the standard of care in oncology offers new hope to patients with advanced NSCLC, potentially establishing a new benchmark in cancer therapy.
Featured photo by CI Photos at Shutterstock.
Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders.
This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.
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View source version on newsdirect.com: https://newsdirect.com/news/new-clinical-data-reveals-maia-biotechnologys-thio-achieves-high-efficacy-in-advanced-non-small-cell-lung-cancer-treatment-599831106
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Press Release
MEKAN (MKN) Token Launches Presale on PinkSale: Redefining E-commerce with Crypto-Powered Rewards

The blockchain community is buzzing with the launch of MEKAN (MKN), a groundbreaking cryptocurrency token currently in its presale stage on the PinkSale platform. Designed to merge the power of decentralized finance (DeFi) with real-world utility, MEKAN Pro is revolutionizing the e-commerce industry through its innovative crypto-integrated business model.
Presale Link: https://www.pinksale.finance/launchpad/ethereum/0xcB9dA5297Ad7E7ce405464fDFDE5B14F3Ed6eD82
What is MEKAN (MKN)?
At its core, MEKAN (MKN) is more than just a token — it’s a gateway to a new era of digital commerce. Through the MEKAN Pro platform, users will enjoy a seamless online shopping experience where cryptocurrency is not just accepted, but rewarded.
Key features include:
- Crypto-Based Loyalty Programs – Earn rewards in MKN tokens for purchases and referrals.
- Exclusive Discounts & Benefits – Holders gain access to members-only deals across partner e-commerce sites.
- DeFi Utility – Stake MKN tokens for passive income and governance participation in the ecosystem.
Presale Now Live on PinkSale
The MEKAN presale gives early supporters a rare opportunity to get in at the ground level. With limited tokens available at a fixed price, this phase offers early investors the best possible entry point before the token hits major DEXs.
Tokenomics Snapshot:
- Token Name: MEKAN
- Symbol: MKN
- Chain: Ethereum
- Presale Platform: PinkSale
- Presale Ends: [2025.04.25 00:00 (UTC)
The presale is already generating excitement from both seasoned investors and e-commerce enthusiasts eager to join a project with tangible real-world utility.
Why MEKAN Pro?
“We’re building more than a token — we’re creating a full ecosystem where consumers are empowered and rewarded for their loyalty and spending,” said the MEKAN Pro team. “By integrating crypto into everyday online shopping, we’re paving the way for a future where digital assets play a key role in consumer behavior.”
Join the MEKAN Movement
To participate in the presale and become part of the future of e-commerce, visit the official PinkSale link above.
For more information, updates, and community involvement:
Website: https://mekan-web.netlify.app/
Twitter: https://x.com/MatteoBona88173
Telegram: https://t.me/+Qd-eaqlf7mYxYmE0
About MEKAN Pro
MEKAN Pro is a visionary crypto-eCommerce platform focused on integrating blockchain technology into online shopping experiences. With the MEKAN (MKN) token at its core, the platform offers real-world utility, user empowerment, and an ecosystem designed to benefit both consumers and businesses.
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Origins to Attend TOKEN2049 Conference
As the global crypto ecosystem enters a new phase, TOKEN2049, one of the most influential and trendsetting annual events in the industry, once again becomes the focal point of worldwide attention. This conference is not only a premier gathering of thought leaders in the Web3 space but also a critical platform for in-depth dialogue and strategic collaboration among project teams, investors, developers, policymakers, and media.
This year’s first TOKEN2049 conference will take place in Dubai from April 30 to May 1, expected to attract over 10,000 attendees and more than 500 leading organizations, covering cutting-edge sectors such as DeFi, AI, infrastructure, public blockchains, NFTs, and GameFi.
And we—the Origins blockchain team—are thrilled to officially announce our participation in this TOKEN2049 conference.
About TOKEN2049
TOKEN2049 is more than just an industry conference; it is a breeding ground for ideas and trends. Its speaker lineup has historically included key figures from transformative organizations and investment firms such as Ethereum, Solana, Chainlink, Circle, Binance, Coinbase, a16z, and Paradigm, spanning the entire spectrum from foundational blockchain infrastructure to application ecosystems.
TOKEN2049 not only showcases the future direction of Web3 development but also creates a multifaceted value loop encompassing project showcases, fundraising opportunities, technical exchanges, global talent recruitment, and community expansion. It serves as an amplifier for the global Web3 narrative, offering Origins a prime opportunity to connect on a broader scale.
Origins: Unlocking the Future
Origins is a high-performance mainnet designed for the future of “AI + Edge + DePIN.” Over the past year, we have achieved significant milestones, from building our technical foundation to deploying core ecosystem modules. Our decision to participate in TOKEN2049 is driven by the following considerations:
Globalizing Technical Output and Value Narrative: Origins has made original advancements in AI empowerment, edge computing node scheduling, and DePIN resource incentive mechanisms, with verifiable progress to showcase. Through TOKEN2049’s premier platform, we aim to communicate our technical foundation and narrative logic to the industry, establishing a strong cognitive anchor.
Fostering Multilateral Ecosystem Collaboration: TOKEN2049 brings together leading global infrastructure projects, L2 Rollup teams, AI service providers, decentralized storage networks, and cross-chain bridge solutions. This presents an unparalleled opportunity for Origins to build a collaborative network, enabling seamless connections across data, computing power, and tasks.
Attracting Funding and Resources: We are advancing Origins’ ecosystem fund, developer incentive programs, and decentralized governance model. TOKEN2049 serves as a strategic entry point to connect with long-term investment institutions and ecosystem participants, helping us strengthen community foundations, DAO governance, and liquidity support systems.
Origins’ Global Ambition: Beyond Footsteps, a Strategic Vision
From its inception, Origins has been committed to a globalized approach to both technology and community. Our team comprises technical experts and researchers from the United States, and we have already established strategic partnerships with multiple distributed computing platforms, AI model service providers, and decentralized storage networks. We have also deployed server clusters across several continents in the U.S., with plans to expand further.
Participating in TOKEN2049 marks a significant step in Origins’ global strategy, propelling us into the industry’s core discourse circle to engage, collaborate, and co-build with the world’s leading peers.
At the conference, we will showcase Origins’ edge computing scheduling model and AI-powered agent incentive mechanisms, demonstrating how tasks can be published, executed, verified, and rewarded without centralized coordination. We will also share our latest technical roadmap. While we cannot guarantee that the roadmap will remain unchanged in the future, we are committed to ensuring it remains optimal. With technological innovation advancing at a breakneck pace, we are determined to stay ahead of the curve.
TOKEN2049: A Starting Point, Not an Endpoint
For Origins, TOKEN2049 is not merely an event to attend—it is a concrete step in executing our global strategy. We look forward to leveraging this conference to achieve value redefinition, ecosystem connectivity, and global brand recognition simultaneously.
Origins firmly believes that in the new era of AI and blockchain convergence, only public blockchains with global technical reach and open collaboration capabilities can truly fulfill the mission of becoming “next-generation decentralized infrastructure.” With TOKEN2049 as our starting point, we will amplify Origins’ voice to the world.
TOKEN2049, we are ready.
Origins, connecting the intelligent world of tomorrow.
Contact Person Name: Peter Wayne
City State: Chicago, United States
Website: https://originspro.com/
Webmail: mailto:rjaynes416@gmail.com
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Michael Emanuele’s “Rehabber Secrets” Tops Amazon Charts, Delivering a Blueprint for Real Estate Project Management Excellence
Canadian author and project management expert offers real-world systems to help homeowners and investors build smarter, faster, and more profitably.
TORONTO, ON – As North America faces rising construction costs, tightening housing supply, and increased demand for rental housing, real estate investors are seeking smarter strategies to manage renovation projects more effectively. Stepping up to meet that need is Canadian project management professional Michael Emanuele, whose newest book, “Rehabber Secrets: The Essential Strategies Every Real Estate Investor Needs to Plan and Manage Successful Property Rehabs”, has become an Amazon #1 bestseller across multiple categories, including Business Systems & Planning, Project Management, and Home Remodeling & Renovation.
“Many investors know how to buy properties. But managing a renovation is where things often fall apart,” says Michael Emanuele. “This book is about turning chaos into clarity, and helping everyday investors renovate like pros.”
Actively involved in over $100 million of completed commercial and residential projects, Michael Emanuele brings a rare combination of architectural knowledge and construction know-how to an industry in need of structure. Rehabber Secrets is a first-of-its-kind playbook that merges enterprise-level project management systems with real estate investing—a space where renovation failure often stems from poor planning, communication breakdowns, and scope mismanagement.
Filling a Critical Gap in the Real Estate Investment World
While countless real estate books emphasize finding deals, using other people’s money (OPM), or financial freedom, Rehabber Secrets targets the execution phase—where profits are either made or lost. Michael emphasizes that failing to plan is planning to fail. The results are missed deadlines, ballooning budgets, and communication breakdowns with contractors. His book flips that script by offering repeatable systems for project planning, contractor coordination, and risk mitigation.
“Many investors are great at finding and funding deals, but when it comes to managing the renovation process, that’s where things fall apart.” says Michael. “Rehabber Secrets helps fill that knowledge gap. It’s walking the walk and talking the talk—applying a system to execute projects with confidence no matter your experience level in construction.”
The book introduces readers to key project management concepts, such as:
- Pre-construction planning and budgeting
- Defining scopes of work into clear work packages
- How to sequence tasks and create realistic timelines
- Subcontractor coordination and communication
- Proactively managing risk to avoid schedule delays and cost overruns
These frameworks aren’t theory—they’re field-tested systems Michael has used to deliver high-performance results in both residential and commercial builds. Readers gain access to strategies typically reserved for high-end construction firms, translated for small-to-midsize real estate projects.
Building Smarter with We Build ADUs
Michael Emanuele’s hands-on experience is also visible through his Ontario-based company, We Build ADUs, a specialized design-build firm that helps homeowners and investors add Additional Dwelling Units (ADUs) to their properties. ADUs are increasingly seen as a solution to Canada’s housing affordability crisis, offering flexible options for multi-generational living, income generation, and gentle urban intensification to take advantage of existing infrastructure while preventing urban sprawl.
With new-housing starts lagging and the cost of real estate rising, Rehabber Secrets arrives at a crucial time. The book provides not only guidance, but a strategic lens on how infill housing and smaller-footprint construction projects can be executed professionally. At We Build ADUs, Michael brings his project management discipline and architectural background into every client engagement, helping them navigate zoning, building permits, planning and construction—all with a transparent, step-by-step process.
Industry Recognition and Growing Influence
Since its release, Rehabber Secrets has received acclaim from professionals across the real estate and construction sectors. It climbed to the #1 spot in Amazon’s Project Management, Business Systems & Planning, and Home Remodeling & Renovation categories and earned a #2 ranking in Real Estate. The book has been praised for its clarity, actionable insights, and the strength of its real-world examples. It’s solidified its place as the go-to manual for real estate professionals looking to improve their property rehab results.
“Rehabber Secrets isn’t about flipping houses,” Michael Emanuele adds. “It’s about building systems that protect time, money, and peace of mind.”
Michael Emanuele’s growing impact in the field has led to speaking invitations at the Region of Waterloo’s Homes for All Summit, as well as national podcasts, real estate workshops, and professional development seminars when he shares his project management secrets—a sorely missing piece in many real estate education programs. His voice is increasingly recognized as an authority on bridging housing policy with on-the-ground execution—especially in the areas of small-scale development and project management.
A Blueprint That Delivers Results
Rehabber Secrets builds on the foundation of Michael Emanuele’s first book, Rehabbing Your Way to Wealth, but takes a significant leap forward. The new book offers a full project management roadmap, adapted for the realities of investors who manage their own construction—whether full-time or on the side.
For newer investors, it removes the guesswork. For seasoned developers, it introduces systems that can improve scalability. And for professionals supporting clients—designers, realtors, lenders—it serves as a shared language for how great projects get delivered.
“My goal has always been to help people avoid the costly mistakes I’ve seen too many investors make,” says Michael Emanuele. “This book is about giving people a time-tested and repeatable formula to manage their own projects with confidence—turning them into project champions.”
About Michael Emanuele:
Michael Emanuele is a Canadian architectural technologist, project management expert, and the founder of We Build ADUs. He is also the author of Rehabber Secrets, an Amazon #1 bestselling book, and a sought-after speaker on the topics of housing accessibility, construction efficiency, and small-scale urban intensification.
Learn more about Michael’s services at: www.WeBuildADUs.ca
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