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PathAI Announces Research Presentations at the 2024 AACR Annual Meeting

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–News Direct–

PathAI, Inc., a leading AI-powered precision pathology company, today announced it will present research from its portfolio of oncology products at the AACR Annual Meeting on April 7-10, 2024, in San Diego, CA. The research demonstrates how machine learning models developed to characterize the tumor microenvironment (TME) from routine hematoxylin and eosin (H&E)-stained whole slide images (WSIs) can be used to advance biomarker development and precision medicine strategies.

The presentations include new research leveraging PathAIs pan-tumor foundation models and its commercially available product, PathExplore1, to identify key histologic features associated with molecular signatures and patient response to therapy. Highlights:

  • Researchers deployed PathExplore on HNSCC and NSCLC samples to characterize the cell and tissue composition of the tumor microenvironment, as well as compute immune phenotypes directly from H&E WSI. (Poster #905)
  • Researchers from Incendia Therapeutics developed a continuous scoring method for Discoidin Domain Receptor 1 (DDR1), which revealed widespread immune exclusion in tumors based on the spatial distribution of lymphocytes, CD8+ T cells, and CD45+ immune cells from H&E and mIF images. DDR1 is highly expressed in epithelial cancers and has been implicated in tumor growth, invasion, and lack of response to therapy. The immune exclusion score correlates with DDR1 mRNA and protein expression. The study provides additional insight into the role of DDR1 in human cancers and may be useful in selecting indications and stratifying patients for DDR1-targeted therapies. (Poster #2916)
  • Using unsupervised learning driven by PathExplores features and a novel collagen fiber detection imaging technology, researchers discovered three distinct phenotypes of cancer associated stroma (CAS) that had distinct patterns of association with survival and gene expression signatures. Two of them were enriched in collagen fiber density as well as in density of fibroblasts, while the third phenotype had the highest density of immune cells, providing a categorization of different types of CAS-tumor interaction that may be useful for patient stratification. (Poster #4912)
  • Using AI-powered models from PathAI, Foundation Medicine researchers investigated digital pathology TME features of immunotherapy outcomes among NSCLC patients within a real-world dataset from the Flatiron Health-Foundation Medicine Clinico-Genomic Database. These results indicate that the composition of the TME assessed via digital pathology may have utility in identifying NSCLC patients who will respond to first-line immune checkpoint inhibitors beyond the established immunotherapy biomarkers. (Poster #4969)
  • In collaboration with EMD Serono, AI-powered TME models from PathAI were used to analyze H&E WSI of NSCLC from a randomized Phase 3 trial directly comparing two immunotherapies. Researchers compared cell abundance features with gene expression data from the same samples and found that immune and stromal cell abundance features were associated with expression of genes in relevant cellular pathways, confirming the biological relevance of our cellular features. In analyzing the features alongside the clinical data from the retrospective study, researchers identified candidate prognostic immunotherapy biomarkers. (Poster #6179)
  • Researchers from Incendia Therapeutics illustrated that morphologic features derived from H&E images using PathExplore can be effective predictors of CD8-defined immune exclusion, providing an option for patient stratification by immune phenotype using widely available H&E images. The features and direction of association align with prior knowledge of the mechanism or manifestations of immune exclusion or infiltration in the TME, including the relative density of lymphocytes in tumor and stroma. (Poster #7392)
  • PathAIs pan-tumor foundation models were used to identify tissue regions and cell types on H&E WSI to quantify tumor purity across multiple tumor types. Model-derived tumor purity estimates were compared to three orthogonal molecular methods of purity and found to correlate across disease indications. These results provide evidence of how AI can improve the efficiency of molecular testing and enhance precision diagnostic strategies. (Poster #7402)

Follow PathAI on LinkedIn and X for more updates from #AACR24 and visit us in person at booth #1549.

Abstract #

Title

Collaborator

Product

Abstract #905

April 7, 2024, 1:30 PM – 5:00 PM

ML quantification of tumor-Infiltrating lymphocytes distinguishes immune-phenotypes and reveals phenotypic heterogeneity

AbbVie

PathExplore

Abstract #2916

April 8, 2024, 1:30 PM – 5:00 PM

Discoidin Domain Receptor 1 (DDR1) expression is associated with degree of immune exclusion across epithelial tumors

Incendia Therapeutics

PathExplore

Abstract #4912

April 9, 2024, 9:00 AM – 12:30 PM

Unsupervised detection of stromal phenotypes with distinct fibrogenic and inflamed properties in NSCLC

N/A

PathExplore

Abstract #4969

April 9, 2024, 9:00 AM – 12:30 PM

Investigating digital pathology tumor microenvironment (TME) biomarkers for immunotherapy (IO) response stratification in patients with advanced non-squamous NSCLC

Foundation Medicine

PathExplore

Abstract #6179

April 9, 2024, 1:30 PM – 5:00 PM

Machine learning (ML)-spatial quantification of the tumor microenvironment (TME) identifies differences associated with response to bintrafusp alfa (BA) vs pembrolizumab (PEM) treatment in the Phase 3 INTR@PID Lung 037 study

EMD Serono

PathExplore

Abstract #7392

April 10, 2024, 9:00 AM – 12:30 PM

Machine learning-based identification of H&E-derived morphologic features associated with CD8+ T cell immune exclusion

Incendia Therapeutics

PathExplore

Abstract #7402

April 10, 2024, 9:00 AM – 12:30 PM

Foundation AI models predict molecular measurements of tumor purity

N/A

1PathExplore is For Research Use Only. Not for use in diagnostic procedures.

About PathAI

PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and laboratory use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases.

PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com.

Contact Details

SVM Public Relations and Marketing Communications

Maggie Naples

+1 401-490-9700

pathai@svmpr.com

Company Website

https://www.pathai.com/

View source version on newsdirect.com: https://newsdirect.com/news/pathai-announces-research-presentations-at-the-2024-aacr-annual-meeting-566770794

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NWAM & Quant Insight reached a strategic cooperation to create new development opportunities and reshape the future of the quantitative market

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In today’s financial markets, data-driven intelligent analysis is rapidly becoming a powerful backing for investors. For New World Asset Management (NWAM), 2024 is destined to be a milestone year, as they have launched a forward-looking collaboration with London-based fintech pioneer Quant Insight. This is not only a technical integration, but also an art of interweaving market trends, data and analysis, allowing investors to stand at the forefront of the market, foresee the future and adjust their strategies.

In today’s financial markets, data-driven intelligent analysis is rapidly becoming a powerful backing for investors. For New World Asset Management (NWAM), 2024 is destined to be a milestone year, as they have launched a forward-looking collaboration with London-based fintech pioneer Quant Insight. This is not only a technical integration, but also an art of interweaving market trends, data and analysis, allowing investors to stand at the forefront of the market, foresee the future and adjust their strategies.

As a company headquartered in London, Quant Insight has provided in-depth market analysis support to hedge funds and asset management companies for many years. They do not simply provide data, but use big data and AI technology to extract truly valuable trends and risk signals from complex market noise. At the beginning of the cooperation, the Quant Insight team had a close dialogue with the NWAM technical team to clarify the goal – not just to bring data to the platform, but to reveal the market behavior and trends behind the data to investors.

“There is a pattern behind every market fluctuation,” said Quant Insight’s chief analyst. “Our task is to find those patterns hidden in the data.”  In this collaboration, engineers from NWAM and Quant Insight worked all night long, and technical experts from both sides discussed face-to-face and continuously polished the system integration plan. In these meetings, every subtle change in the market became the focus of discussion. In Q1 2024, they jointly launched the first market analysis tool based on the Quant Insight quantitative analysis system. NWAM users can now gain deep insights into market trends through real-time data on the platform.

However, simply analyzing the market is not enough. The real challenge lies in how to optimize investment strategies through these data. Quant Insight is well aware of this. Therefore, in Q2 2024, NWAM continued to work with the Quant Insight team to launch an optimization tool for investment strategies. This tool not only helps investors draw conclusions from quantitative analysis, but also provides them with a series of possible strategy adjustment options.  “We don’t want investors to just passively follow the market,” said NWAM’s CEO. “We want them to be proactive and use the most appropriate strategies to seize market opportunities.”

This is not just a simple theoretical analysis, every investor who uses quantitative tools will receive personalized strategy advice. Whether they are facing the volatility of global stock markets or the rapid rise and fall of cryptocurrencies, this set of tools can provide accurate market reaction advice.  From the initial negotiation to the implementation of the tool, the teams of both parties have always adhered to one goal: to empower global users with intelligent, data-driven investment decisions. When talking about the cooperation, the chief data scientist of Quant Insight said with deep emotion: “Working with NWAM, our technology no longer only serves top hedge funds, but also helps a wider range of global investors.”

The significance of this cooperation lies not only in technological breakthroughs, but also in the reshaping of future investor behavior. Through this cooperation, NWAM has expanded the vision of its global user base from traditional market analysis to a whole new level. Quant Insight’s AI quantitative analysis technology not only enhances the market insight of the NWAM platform, but also provides professional and amateur investors around the world with equally accurate market judgment tools.  In the future, this cooperation will continue to deepen. The NWAM team is already planning more system upgrades and tool development to expand Quant Insight’s quantitative analysis to more asset classes and markets. The cooperation between NWAM and Quant Insight is not just a combination of technologies, but also a bold imagination of the future of financial technology.  As the founder of Quant Insight said: “The market has never been so transparent, and we are making future investment decisions clearer.”  The changes brought about by this cooperation are no longer the exclusive domain of a few people, but will become an opportunity for every investor. Whether you are a hedge fund manager or a novice investor, the cooperation between NWAM and Quant Insight will ultimately provide you with tools to gain insight into the market and control the future.

Media Contact

Organization: New World Asset Management Ltd

Contact Person: Don Adam Perera

Website: https://newworldeco.com

Email: Send Email

Country: United States

Release Id: 19102418670

The post NWAM & Quant Insight reached a strategic cooperation to create new development opportunities and reshape the future of the quantitative market appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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Press Release

Linear Finance to Showcase Innovative DeFi Solutions at Chainlink SmartCon 2024

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Hong Kong, 19th Oct 2024 – Linear Finance is excited to announce its participation as a booth sponsor at the highly anticipated Chainlink SmartCon 2024, taking place on October 30-31. Positioned at Booth S5, centrally located on the conference floor, Linear Finance will present its latest advancements in decentralized finance (DeFi) to a global audience of blockchain leaders, innovators, and developers.

Recognized as one of the premier events in the blockchain and cryptocurrency space, SmartCon 2024 will gather thousands of attendees, offering Linear Finance an unparalleled opportunity to showcase its cutting-edge technologies, foster strategic partnerships, and contribute to the continued growth of the DeFi ecosystem.

Linear Finance will spotlight several key innovations, including its Perpetual DEX (Perp DEX), which offers seamless, frictionless trading with advanced features. The team will also introduce attendees to the latest upgrade of its multi-chain marketplace, featuring a dynamic discount function and the migration from BUSD to USDT. These enhancements reflect Linear’s ongoing commitment to making DeFi more accessible, functional, and user-friendly.

The event will also provide a platform to discuss Linear Finance’s broader roadmap, which includes expanded cross-chain interoperability, infrastructure developments for decentralized trading, and key upcoming partnerships. Attendees will have the unique opportunity to engage directly with the Linear team, explore the technology firsthand, and gain insights into the future of decentralized finance.

We are thrilled to be part of SmartCon 2024, where we can connect with the broader DeFi community,” said George, Business Development Manager at Linear Finance. “Linear Finance is at a pivotal moment, and we are eager to share our latest innovations and our vision for the future of DeFi.

Throughout the two-day event, the Linear Finance team will be available at Booth S5 to provide live demos and answer questions. For more information about Linear Finance’s presence at SmartCon 2024, or to schedule media interviews, please visit the website or contact the team.

Connect with Linear Finance: Discord || X || Medium 

About Linear Finance: 

Linear Finance is a decentralized finance platform that enables users to trade synthetic assets quickly, seamlessly, and cost-effectively. Offering a range of services such as staking and decentralized financial tools, Linear focuses on building a comprehensive DeFi ecosystem powered by a robust governance model that empowers community-driven decision-making.

Media Contact

Organization: Liner Finance

Contact Person: George [BDM at Linear Finance]

Website: https://linear.finance/

Email: Send Email

Country: Hong Kong S.A.R.

Release Id: 19102418663

The post Linear Finance to Showcase Innovative DeFi Solutions at Chainlink SmartCon 2024 appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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YTL Foundation Builds BURN Ecology – BURN BANK: Opening a New Era of Blockchain Finance

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Against the backdrop of the increasing innovation of blockchain technology and the rapid rise of decentralized finance (DeFi), the YTL Foundation is keenly aware of the huge potential of the BURN token and is determined to vigorously promote the development of this project. The BURN token not only represents the transformation of digital finance in the future, but also carries a new vision of financial ecology. With the support of the YTL Foundation, the birth of the BURN Bank ecosystem will completely subvert the traditional financial model and lead the new trend of blockchain banking.

BURN Ecological Background: The Strategic Layout of the YTL Foundation

As the world’s leading innovative investment institution, YTL Foundation has been focusing on promoting the application and development of blockchain technology and digital assets. Through years of accumulation of technology, resources and capital, YTL Foundation is well aware that the financial market is undergoing a profound transformation – the transformation from the traditional centralized system to decentralized finance. Due to its unique technical architecture and unlimited application scenarios in the future, the BURN token has become the core project of the YTL Foundation’s key layout.

YTL Foundation is not only an investor in the BURN project, but also a strategic promoter of the BURN Bank ecosystem. By injecting huge amounts of capital and global resources, YTL Foundation is committed to building a comprehensive ecosystem that integrates diversified applications such as finance, lending, blockchain games (GameFi), and NFTs.

YTL Foundation’s capital volume and physical industry layout

YTL Foundation has a strong capital base, and its capital scale is among the best in the industry, covering a number of real industry sectors, including mainstream industries such as hotels, energy, and electricity. Taking the hotel industry as an example, the YTL Foundation has a number of high-end hotels, covering a wide range of choices from luxury resorts to business hotels, forming a tourism and accommodation network covering both domestic and foreign markets. These hotels not only provide excellent services to tourists, but also contribute to the development and prosperity of the region through integration with the local economy.

In the field of power and energy, the YTL Foundation also plays an important role. By investing in green energy projects, such as wind and solar, the Foundation is not only promoting the use of renewable energy, but also contributing to the sustainable development of society. The stable income and extensive influence of these real industries have enabled YTL Foundation to have solid capital strength, so as to better support the construction and development of the BURN Bank ecosystem.

The fundamental reason for developing the BURN Bank ecosystem is that YTL Foundation hopes to step into the blockchain industry and combine traditional financial services with digital assets to create a combination of digital and real effects. By combining the real industry with blockchain technology, the BURN Bank ecosystem not only provides users with financial services, but also creates more investment opportunities for users and promotes the overall development of the economy.

Eco-Tech Innovation: Leading the Future of Blockchain Banking

The technology architecture and operating model of the BURN Bank ecosystem is one of its biggest highlights. It not only innovatively applies blockchain technology, but also realizes the function of automatic fund entry and exit and real-time arrival in the form of smart contracts. The application of this technology makes the flow of funds in the BURN Bank ecosystem more efficient and secure, and greatly reduces the possibility of human intervention, thereby reducing the risk in financial operations.

Smart contracts automate execution to ensure that funds can be transferred from account to account quickly and securely, completely disrupting the lengthy processes and high fees of traditional banks. What’s more noteworthy is that BURN Bank has created a margin mechanism. The introduction of this mechanism provides a double guarantee for all participants – not only to ensure the smooth completion of transactions, but also to effectively prevent malicious behavior, and improve the trust of the entire ecosystem.

At the same time, the BURN ecosystem ensures that the security of users’ assets is protected to the greatest extent through multi-layer encryption technology and decentralized architecture. In the current blockchain market, although many projects claim to provide financial security, the technical architecture of the BURN ecosystem is undoubtedly at the forefront of the industry. Through real-time monitoring and smart contract execution, BURN Bank not only provides users with an efficient financial trading platform, but also sets a benchmark for the development of global blockchain banks.

Ecological security: Ensure the safety and stability of user assets

In the BURN ecosystem, safety is always one of the most important considerations. To this end, a margin storage mechanism has been established within the ecosystem to serve as a reserve for the return of principal. This not only effectively protects the rights and interests of both parties to the transaction, but also minimizes potential financial risks.

In addition, the BURN ecosystem uses BURN tokens as the circulating currency, and BURN tokens have a unique burning mechanism, which ensures the scarcity of tokens and the steady growth of prices by reducing the total amount of circulation in the market. In each transaction, a portion of the BURN tokens is automatically burned, further driving the long-term value growth of the BURN tokens. This continued reduction in supply means that the BURN token will gradually become a scarce resource, which in turn will attract more investor attention and participation. 

Ecological Prospect and Planning: Steadily promote the transformation of the future financial landscape

BURN Bank is more than just a blockchain bank, it carries the blueprint for the future of decentralized finance. Its development plan is not only limited to stabilizing the price of BURN tokens, but also covers the exploration of more innovative applications and scenarios. As an open financial ecosystem, BURN aims to continuously expand its application boundaries, meet the financial needs of users around the world, and drive the entire blockchain industry forward.

Stabilize the price and promote the BURN token to become a mainstream asset

The YTL Foundation and the BURN team understand that the price stability of digital assets is the key to driving market confidence and long-term development. Therefore, the primary task of the BURN ecosystem is to ensure the price stability of the BURN token and gradually increase its market value through diversified applications and a reasonable economic model. Through margin mechanism and liquidity management, BURN token can effectively avoid market volatility and provide users with safe and stable financial tools.

In order to further enhance BURN’s market position, the BURN team plans to gradually roll out its token to major exchanges around the world. This move will not only bring broader market liquidity to the BURN token, but will also help it become one of the world’s mainstream digital assets. Through cooperation with the world’s top trading platforms, the BURN token will gradually cover global users and establish partnerships with more financial institutions to promote its application in the international financial market.

Open the blockchain game and NFT market: explore more possibilities of blockchain

In addition to traditional financial functions, the BURN ecosystem will also enter the game-gaming (GameFi) and NFT (non-fungible token) markets to further expand its application scenarios. As an emerging market in the blockchain industry, blockchain games have broad potential and development space. BURN BANK WILL DEVELOP A NUMBER OF BLOCKCHAIN GAME PROJECTS BASED ON ITS STRONG TECHNICAL FOUNDATION, SO THAT USERS CAN NOT ONLY PARTICIPATE IN FINANCIAL TRANSACTIONS, BUT ALSO EARN MONEY THROUGH GAMES. The combination of blockchain games and NFT marketplaces not only injects new vitality into the BURN ecosystem, but also provides users with more diversified ways to participate.

In the NFT field, the BURN ecosystem will launch a number of unique assets based on blockchain technology, such as artworks, collectibles, virtual real estate, etc., to further enrich the application scenarios of BURN. Through these innovative applications, BURN will attract more users and investors to its ecosystem and increase the market demand and value of the BURN token.

Launch of the lending system: Build a comprehensive decentralized financial platform

As the BURN Bank ecosystem continues to expand, its future plans also include the launch of a decentralized lending system. The introduction of the lending system will provide users with more asset management options and help BURN Bank build a comprehensive financial platform. Through decentralized lending, users can use BURN tokens as collateral to obtain liquidity support, so as to meet their funding needs in different scenarios. This system can not only enhance the application value of the BURN token, but also promote the liquidity cycle of the entire ecosystem and enhance its market competitiveness.

Future Prospects: The Global Layout and Vision of the BURN Ecosystem

The YTL Foundation’s collaboration with the BURN team is not just to build a blockchain finance project, but to move the entire industry forward. In the process of global layout, the BURN team has always insisted on paying equal attention to technological innovation and user experience, and is committed to providing a safe, efficient and decentralized financial platform for global users. In the future, the BURN ecosystem will continue to expand its global user base and establish cooperation with blockchain projects, government agencies and financial institutions in various countries to promote the wide application of blockchain technology.

The BURN ecosystem is not just a project, it represents the future of blockchain finance. Through technological innovation, globalization strategy and diversified application scenarios, the BURN ecosystem will surely occupy a place in the future financial field. The strong support and financial strength of the YTL Foundation will provide a steady stream of power for the growth of the BURN ecosystem, help it rise rapidly in the blockchain industry, and become an important force leading the industry change.

conclusion

The construction of the BURN Bank ecosystem is not only an important step for YTL Foundation to step into the blockchain industry, but also a deep thinking and innovative exploration of the future financial model. In this ecosystem, YTL Foundation is shaping a safe, efficient, and creative financial ecosystem by combining its rich experience in the real industry with the cutting-edge application of blockchain technology. In the future, the BURN token will not only be a digital asset, but also an important bridge between traditional finance and decentralized finance.

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